Results 81 to 90 of about 37,091 (247)

Early biomarkers in the presymptomatic phase of cognitive impairment: changes in the endocannabinoidome and serotonergic pathways in Alzheimer's-prone mice after mTBI

Acta Neuropathologica Communications
Background Despite extensive studies on the neurobiological correlates of traumatic brain injury (TBI), little is known about its molecular determinants on long-term consequences, such as dementia and Alzheimer’s disease (AD).
Francesca Guida, Monica Iannotta, Anna Lauritano, Rosmara Infantino, Emanuela Salviati, Roberta Verde, Livio Luongo, Eduardo Maria Sommella, Fabio Arturo Iannotti, Pietro Campiglia, Sabatino Maione, Vincenzo Di Marzo, Fabiana Piscitelli   +12 more
doaj   +1 more source

Plasma concentrations of endocannabinoids and related primary Fatty Acid amides in patients with post-traumatic stress disorder. [PDF]

, 2013
Endocannabinoids (ECs) and related N-acyl-ethanolamides (NAEs) play important roles in stress response regulation, anxiety and traumatic memories. In view of the evidence that circulating EC levels are elevated under acute mild stressful conditions in ...
Kolassa, Iris-Tatjana, Schelling, G., Roozendaal, B., Campolongo, P., Gola, Hannah, Benno Roozendaal, Morath, Julia, Julia Morath, Vogeser, M., Alexander Karabatsiakis, Iris-Tatjana Kolassa, Atsak, Piray, Gustav Adolf Schelling, Patrizia Campolongo, Michael Vogeser, Piray Atsak, Campolongo, Patrizia, Roozendaal, Benno, Karabatsiakis, A., Gola, H., Schelling, Gustav, Vogeser, Michael, Iris Tatjana Kolassa, Atsak, P., Kolassa, I.T., Gilava Hamuni, Hannah Gola, Gustav Schelling, Daniela Hauer, Hamuni, G., Morath, J., Hauer, D., Karabatsiakis, Alexander, Hauer, Daniela, Hamuni, Gilava   +34 more
core   +1 more source

Inhibition of peripheral CB1 receptors modulates food intake and metabolic efficiency in obesity independently of the gut–brain vagal axis

British Journal of Pharmacology, EarlyView.
Background and Purpose Obesity involves profound disruptions in neuronal circuits, neuroendocrine communication and the endocannabinoid system. While global blockade of cannabinoid CB1 receptors improves metabolism, its clinical use is limited by neuropsychiatric side effects.
Oriane Onimus, Camille de Almeida, Benoit Bertrand, Julien Castel, Nejmeh Mashhour, Anthony Ansoult, Serge Luquet, Giuseppe Gangarossa   +7 more
wiley   +1 more source

Pregnancy success in mice requires appropriate cannabinoid receptor signaling for primary decidua formation

eLife, 2020
With implantation, mouse stromal cells begin to transform into epithelial-like cells surrounding the implantation chamber forming an avascular zone called the primary decidual zone (PDZ).
Yingju Li, Amanda Dewar, Yeon Sun Kim, Sudhansu K Dey, Xiaofei Sun   +4 more
doaj   +1 more source

Circadian disruption elicits sex‐specific gut microbiota, endocannabinoidome, and lipid mediator responses

The FEBS Journal, EarlyView.
Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki, Timothy D. Niepokny, Tina Khalilzadehsabet, Elizabeth Dumais, Nicolas Flamand, Vincenzo Di Marzo, Eric M. Mintz, Cristoforo Silvestri   +7 more
wiley   +1 more source

Assay of Endocannabinoid Uptake

, 2016
Endocannabinoids at physiological concentrations are crossing cellular membranes by facilitated diffusion, a process that can be studied by measuring transport kinetics.
Gertsch, Jürg, Mark Rau, Simon Nicolussi, Jürg Gertsch, Rau, Mark, Chicca, Andrea, Nicolussi, Simon, Andrea Chicca   +7 more
core   +1 more source

Assessment of Cannabidiol Supplements Use in Small Animals Practice in Portugal

Journal of Animal Physiology and Animal Nutrition, EarlyView.
ABSTRACT This study aimed to assess the current use of cannabidiol supplements (CBDS) by Portuguese small animal veterinary practitioners. An anonymous online survey questioning the frequency of CBDS use, purpose of use and the perceived outcome was developed using Microsoft Forms, and targeted veterinarians currently working in small animal clinics in
Maria Inês Santos, Ana Luísa Lourenço
wiley   +1 more source

Cannabinoid CB2 Receptor Gene and Environmental Interaction in the Development of Psychiatric Disorders

Molecules, 2018
CB2 cannabinoid receptor (CB2R) gene is associated with depression. We investigated the gene-environment interaction between CB2R function and diverse stressors.
Hiroki Ishiguro, Yasue Horiuchi, Koichi Tabata, Qing-Rong Liu, Tadao Arinami, Emmanuel S. Onaivi   +5 more
doaj   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Endocannabinoid transport revisited.

, 2015
Endocannabinoids are arachidonic acid-derived endogenous lipids that activate the endocannabinoid system which plays a major role in health and disease.
Gertsch, Jürg, Simon Nicolussi, Jürg Gertsch, Nicolussi, Simon   +3 more
core   +1 more source