Results 91 to 100 of about 37,091 (247)

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source

Interação entre os sistemas endocanabinóide e glicocorticóide na extinção do condicionamento aversivo contextual em ratos [PDF]

, 2012
Tese (doutorado) - Universidade Federal de Santa Catarina, Centro de Ciências Biológicas. Programa de Pós-Graduação em FarmacologiaA regulação das respostas emocionais é essencial para a saúde mental e a forma mais simples de regulação destas respostas é
Bitencourt, Rafael Mariano de
core  

Serum contents of endocannabinoids are correlated with blood pressure in depressed women.

, 2012
BACKGROUND: Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in ...
Ho, WS V, Miller, GE, Hillard, CJ, Ho WS Vanessa, WS Vanessa Ho, Hillard, Cecilia J., Gorzalka, Boris B., Miller, Gregory E, Hill Matthew N, Hillard Cecilia J, Hill, MN, Gorzalka, Boris B, Gregory E Miller, Hill, Matthew N, Miller Gregory E, Hillard, Cecilia J, Ho, Vanessa, Miller, Gregory E., Matthew N Hill, Gorzalka, BB, Boris B Gorzalka, Cecilia J Hillard, Hill, Matthew N., Gorzalka Boris B, Ho, WS   +24 more
core   +1 more source

Binding and Signaling Studies Disclose a Potential Allosteric Site for Cannabidiol in Cannabinoid CB2 Receptors

Frontiers in Pharmacology, 2017
The mechanism of action of cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa L., is not completely understood. First assumed that the compound was acting via cannabinoid CB2 receptors (CB2Rs) it is now suggested that it interacts ...
Eva Martínez-Pinilla, Katia Varani, Irene Reyes-Resina, Irene Reyes-Resina, Edgar Angelats, Edgar Angelats, Fabrizio Vincenzi, Carlos Ferreiro-Vera, Julen Oyarzabal, Enric I. Canela, Enric I. Canela, José L. Lanciego, Xavier Nadal, Gemma Navarro, Gemma Navarro, Gemma Navarro, Pier Andrea Borea, Rafael Franco, Rafael Franco   +18 more
doaj   +1 more source

Are endocannabinoid type 1 receptor gene (CNR1) polymorphisms associated with obesity and metabolic syndrome in postmenopausal Polish women?

, 2009
Objective: The aim of this study was to determine whether genetic variation at the cannabinoid receptor-1 (CNR1) locus could have an effect on adiposity, fat distribution and obesity-related metabolic disorders in Polish postmenopausal women.Design and ...
Felicja Lwow, Diana Jedrzejuk, Lukasz Laczmanski, Andrzej Milewicz, Katarzyna Dunajska, Urszula Tworowska-Bardzinska   +5 more
core  

2-Arachidonoylglycerol impairs human cytotrophoblast cells syncytialization: influence of endocannabinoid signalling in placental development

, 2015
A balanced cytotrophoblast cell turnover is crucial for placental development and anomalies in this process associated with gestational diseases. The endocannabinoid system (ECS) has emerged as a new player in several biological processes.
Keating, E., Fonseca, B. M., Teixeira, N. A., Correia-da-Silva, G., Costa, M. A.   +4 more
core   +1 more source

Exploring the Role of Dysregulated Arousal in the Relationship Between Trauma and Addictive Behaviors Among College Students

Journal of Counseling &Development, Volume 104, Issue 3, Page 373-385, July 2026.
ABSTRACT The relationship between trauma and addictive behaviors is well‐established, yet factors mediating this relationship remain understudied. Given the prevalence of addictive behaviors among collegiate populations, we used path analysis to explore the mediating role of arousal dysregulation in the relationship between childhood trauma and a ...
Amanda L. Giordano, Kate M. Dorrough, Deborah L. Smith, Peitao Zhu   +3 more
wiley   +1 more source

Pharmacological potential of endocannabinoid and endocannabinoid-like compounds in protecting intestinal structure and metabolism under high-fat conditions

Frontiers in Pharmacology
The intestine plays a crucial role in nutrient absorption, digestion, and regulation of metabolic processes. Intestinal structure and functions are influenced by several factors, with dietary composition being one of the most significant.
Francesco Vari, Francesco Vari, Ilaria Serra, Ilaria Serra, Marzia Friuli, Viviana Cavallo, Nicola Gammaldi, Daniele Vergara, Michel Salzet, Anna M. Giudetti   +9 more
doaj   +1 more source

Differential subcellular recruitment of monoacylglycerol lipase generates spatial specificity of 2-arachidonoyl glycerol signaling during axonal pathfinding [PDF]

, 2010
Peer ...
Klaudia Barabas, Yanagawa, Yuchio, Harkany, Tibor, Giuseppe Tortoriello, Masaaki Torii, Cameron, Gary, Yuchio Yanagawa, Tortoriello, Giuseppe, Gary Cameron, Morozov, Yury M, Watanabe, Masahiko, Masahiko Watanabe, Barabas, Klaudia, Erik Keimpema, Ken Mackie, Keimpema, Erik, Tibor Harkany, Yury M. Morozov, Torii, Masaaki, Mackie, Ken   +19 more
core   +1 more source

Visualization of Endocannabinoids in the Cell

, 2016
A still unsolved, although critical, issue in endocannabinoid research is the mechanism by which the lipophilic compound anandamide (AEA) moves from its site of synthesis, crosses the aqueous milieu, and reaches the different intracellular compartments, where its metabolic and signaling pathways take place.
Oddi S, Totaro A, Maccarrone M
openaire   +2 more sources