Results 91 to 100 of about 54,731 (237)
N-Arachidonoyl Dopamine Modulates Acute Systemic Inflammation via Nonhematopoietic TRPV1. [PDF]
, 2017 N-Arachidonoyl dopamine (NADA) is an endogenous lipid that potently activates the transient receptor potential vanilloid 1 (TRPV1), which mediates pain and thermosensation. NADA is also an agonist of cannabinoid receptors 1 and 2.
Hellman, Judith +7 more
core +2 more sources
Guessing at Ghosts in the Machine
Ratio, EarlyView.ABSTRACT As AI grows ever more complex and ubiquitous, its moral status becomes increasingly pressing. But knowing whether an AI has moral status is only part of the ethical puzzle. To determine how we ought to treat such entities, we must know not only whether AIs have moral status, but also about the content of their interests—what contributes to ...
Helen Yetter‐Chappell
wiley +1 more source
Endogenous Dopamine and Endocannabinoid Signaling Mediate Cocaine-Induced Reversal of AMPAR Synaptic Potentiation in the Nucleus Accumbens Shell [PDF]
, 2018 Repeated exposure to drugs of abuse alters the structure and function of neural circuits mediating reward, generating maladaptive plasticity in circuits critical for motivated behavior.
Hearing, Matthew +3 more
core +2 more sources
Endocannabinoid-related compounds in gastrointestinal diseases [PDF]
, 2018 The endocannabinoid system (ECS) is an endogenous signalling pathway involved in the control of several gastrointestinal (GI) functions at both peripheral and central levels.
Alessandra, D'Alessandro +7 more
core +1 more source
Experimental Physiology, EarlyView.Abstract The present review aimed to investigate the effectiveness of aerobic exercise (AE) compared to other interventions in decreasing pain intensity and reducing disability in individuals with neck pain. A systematic review (SR) of randomized controlled trials was conducted. This SR was registered in PROSPERO (CRD42021231231).
Ana lzabela Sobral de Oliveira‐Souza +9 more
wiley +1 more source
Phenotype-Based Screening of Synthetic Cannabinoids in a Dravet Syndrome Zebrafish Model. [PDF]
, 2020 Dravet syndrome is a catastrophic epilepsy of childhood, characterized by cognitive impairment, severe seizures, and increased risk for sudden unexplained death in epilepsy (SUDEP).
Anvar, Mana +3 more
core +1 more source
Cannabinoid receptor CB2 drives HER2 pro-oncogenic signaling in breast cancer [PDF]
, 2015 Pharmacological activation of cannabinoid receptors elicits antitumoral responses in different models of cancer. However, the biological role of these receptors in tumor physio-pathology is still unknown.
Alkatout, Ibrahim +31 more
core +1 more source
Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes
The Journal of Physiology, EarlyView.Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone +1 more
wiley +1 more source
Frontiers in Pharmacology, 2017 The mechanism of action of cannabidiol (CBD), the main non-psychotropic component of Cannabis sativa L., is not completely understood. First assumed that the compound was acting via cannabinoid CB2 receptors (CB2Rs) it is now suggested that it interacts ...
Eva Martínez-Pinilla +18 more
doaj +1 more source
Cognitive impairment induced by delta9-tetrahydrocannabinol occurs through heteromers between cannabinoid CB1 and serotonin 5-HT2A receptors [PDF]
, 2015 Delta-9-tetrahydrocannabinol (THC), the main psychoactive compound of marijuana, induces numerous undesirable effects, including memory impairments, anxiety, and dependence.
A Busquets-Garcia +112 more
core +6 more sources