Results 71 to 80 of about 41,114 (259)

Hypothalamic Control of Brown Adipose Tissue Thermogenesis

open access: yesFrontiers in Systems Neuroscience, 2015
It has long been known, in large part from animal studies, that the control of brown adipose tissue (BAT) thermogenesis is insured by the central nervous system, which integrates several stimuli in order to control BAT activation through the sympathetic ...
Sebastien M Labbe*   +5 more
doaj   +1 more source

Pharmacological characterization of a novel, potent, selective, and orally active fatty acid amide hydrolase inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroman‐4‐yl)piperazine‐1‐carboxamide] in rats: Potential for the treatment of inflammatory pain

open access: yesPharmacology Research & Perspectives, 2020
Recently, we identified a novel fatty acid amide hydrolase (FAAH) inhibitor, PKM‐833 [(R)‐N‐(pyridazin‐3‐yl)‐4‐(7‐(trifluoromethyl)chroman‐4‐yl)piperazine‐1‐carboxamide].
Toshiya Endo   +2 more
doaj   +1 more source

Subchronic Exposure to Cannabis‐Based Nanoemulsions Induces Histopathological and Molecular Alterations in the Rat Submandibular Gland

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT The increasing therapeutic incorporation of cannabis has expanded phytocannabinoid application, yet peripheral adverse effects like xerostomia raise concerns regarding emerging biotechnological formulations. This study evaluated the effects of cannabis‐based lipid nanoemulsions on the rat submandibular gland parenchyma.
Lorrany Avanci Bullo   +10 more
wiley   +1 more source

Serum contents of endocannabinoids are correlated with blood pressure in depressed women. [PDF]

open access: yes, 2012
BACKGROUND: Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in ...
Ho, WS V   +24 more
core   +1 more source

How much walking is enough for chronic low back pain? A systematic review and dose–response meta‐analysis

open access: yesPM&R, EarlyView.
Abstract Objective To determine the dose–response relationship of a walking program and compare different delivery methods of walking exercise for patients with chronic low back pain (CLBP). Methods A systematic search of PubMed/MEDLINE, Web of Science, Scopus, Embase, and the Cochrane Library was conducted from inception to October 21, 2024.
Rodrigo Núñez‐Cortés   +8 more
wiley   +1 more source

Untersuchungen zur Rolle des endogenen Cannabinoidsystems bei der Anpassung an aversive Situationen [PDF]

open access: yes, 2006
Ziel der vorliegenden Arbeit war es zu untersuchen, auf welche Art und Weise das endogene Cannabinoidsystem die Extinktion konditionierter Furcht vermittelt. Dabei gliedert sich diese Arbeit in vier Teile.
Kamprath, Kornelia
core   +1 more source

Impact of cannabis, cannabinoids and endocannabinoids in the lungs

open access: yesFrontiers in Pharmacology, 2016
Since the identification of cannabinoid receptors in the 1990s, a research field has been dedicated to exploring the role of the cannabinoid system in immunity and the inflammatory response in human tissues and animal models.
Caroline Turcotte   +3 more
doaj   +1 more source

Endocannabinoid System Components as Potential Biomarkers in Psychiatry

open access: yesFrontiers in Psychiatry, 2020
The high heterogeneity of psychiatric disorders leads to a lack of diagnostic precision. Therefore, the search of biomarkers is a fundamental aspect in psychiatry to reach a more personalized medicine.
Francisco Navarrete   +15 more
doaj   +1 more source

Plant‐Derived Bioactives and PPAR Signaling in Functional Dyspepsia: Mechanistic Insights and Therapeutic Perspectives

open access: yesPhytotherapy Research, EarlyView.
Functional dyspepsia involves duodenal barrier dysfunction, low‐grade immune activation and altered neuroimmune signalling. Various plant‐derived bioactives may modulate PPAR signalling, reduce inflammatory and oxidative stress, and support epithelial, immune, metabolic, and sensory homeostasis.
Irene Palenca   +5 more
wiley   +1 more source

Endocannabinoid transport revisited. [PDF]

open access: yes, 2015
Endocannabinoids are arachidonic acid-derived endogenous lipids that activate the endocannabinoid system which plays a major role in health and disease.
Gertsch, Jürg   +3 more
core   +1 more source

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