Results 1 to 10 of about 509 (127)

The human milk endocannabinoidome and neonatal growth in gestational diabetes [PDF]

Frontiers in Endocrinology
ObjectiveEndocannabinoids and their N-acyl-ethanolamines (NAEs) and 2monoacyl-glycerols (2-MAGs) congeners are involved in the central and peripheral regulation of energy homeostasis, they are present in human milk and are associated with obesity ...
Nicolas Flamand, Julie Robitaille, Alain Veilleux   +2 more
exaly   +6 more sources

Seasonal variations in circulating endocannabinoidome mediators and gut microbiota composition in humans [PDF]

Gut Microbes
Background The human gut microbiome-endocannabinoidome axis is crucial for several homeostatic processes, including inflammation and energy metabolism, and is influenced by many endogenous and exogenous factors, such as dietary habits. Changes in the gut
Sophie Castonguay-Paradis, Élisabeth Demers-Potvin, Gabrielle Rochefort, Sébastien Lacroix, Julie Perron, Cyril Martin, Nicolas Flamand, Frédéric Raymond, Vincenzo Di Marzo, Alain Veilleux   +9 more
doaj   +4 more sources

Rapid and Concomitant Gut Microbiota and Endocannabinoidome Response to Diet-Induced Obesity in Mice

MSystems, 2019
The intestinal microbiota and the expanded endocannabinoid (eCB) system, or endocannabinoidome (eCBome), have both been implicated in diet-induced obesity and dysmetabolism.
Cristoforo Silvestri, Nicolas Flamand, Vincenzo Di Marzo   +2 more
exaly   +7 more sources

Mutual Links between the Endocannabinoidome and the Gut Microbiome, with Special Reference to Companion Animals: A Nutritional Viewpoint [PDF]

Animals, 2022
There is growing evidence that perturbation of the gut microbiome, known as “dysbiosis”, is associated with the pathogenesis of human and veterinary diseases that are not restricted to the gastrointestinal tract.
Vincenzo Di Marzo, Stefania Petrosino, Petrosino Stefania   +2 more
exaly   +5 more sources

Defining the Intestinal eCBome and Oxylipin Signaling Systems in a TDP-43 Mouse Model of Frontotemporal Dementia. [PDF]

FASEB J
TDP‐43 overexpressing mice, a genetic model of frontotemporal dementia, exhibit dramatic changes in their small intestinal endocannabinoidome members, in terms of both altered concentrations of lipid mediators and expression of some of their receptors (Cnr1, Gpr119, Gpr55, Pparg) and metabolic enzymes (Napepld, Faah). Also, the levels of some oxylipins
Mir HD, Giorgini G, Santos-García I, Dumais E, Rodríguez-Cueto C, de Lago E, Silvestri C, Flamand N, Fernández-Ruiz J, Di Marzo V.   +9 more
europepmc   +2 more sources

Targeting the LPI/GPR55 Axis in MAFLD and MASH: Novel Insights, Therapeutic Strategies and Future Directions. [PDF]

Liver Int
ABSTRACT Metabolic dysfunction‐associated fatty liver disease (MAFLD), recently redefined from non‐alcoholic fatty liver disease (NAFLD), highlights the central role of metabolic dysfunction in its pathophysiology. The L‐α‐lysophosphatidylinositol/G protein‐coupled receptor 55 (LPI/GPR55) axis, an element of the endocannabinoidome, has emerged as a key
Lian J, Lareu RR, Patil M, Falasca M.
europepmc   +2 more sources

Linking the Endocannabinoidome with Specific Metabolic Parameters in an Overweight and Insulin-Resistant Population: From Multivariate Exploratory Analysis to Univariate Analysis and Construction of Predictive Models

Cells, 2021
The global obesity epidemic continues to rise worldwide. In this context, unraveling new interconnections between biological systems involved in obesity etiology is highly relevant.
Nicolas Flamand, Amandine Everard, Rudy Pelicaen   +2 more
exaly   +3 more sources

Investigating Properties of Palmitoylethanolamide in Physiology and Disease: Far Beyond an Anti-Inflammatory Shield [PDF]

Diseases
Palmitoylethanolamide (PEA) among N-acylethanolamides displays a noteworthy impact on different inflammatory conditions and promises to become a valuable anti-inflammatory tool that does not interfere with the cyclooxygenase pathway.
Chiara Veredice, Ida Turrini, Helena Pelanda, Ilaria Contaldo, Donato Rigante   +4 more
doaj   +2 more sources

Impact of selenium on the intestinal microbiome-eCBome axis in the context of diet-related metabolic health in mice [PDF]

Frontiers in Immunology, 2022
Dietary micronutrients act at the intestinal level, thereby influencing microbial communities, the host endocannabinoidome, and immune and anti-oxidative response. Selenium (Se) is a trace element with several health benefits.
Fredy Alexander Guevara Agudelo, Fredy Alexander Guevara Agudelo, Fredy Alexander Guevara Agudelo, Nadine Leblanc, Nadine Leblanc, Nadine Leblanc, Isabelle Bourdeau-Julien, Isabelle Bourdeau-Julien, Isabelle Bourdeau-Julien, Gabrielle St-Arnaud, Gabrielle St-Arnaud, Gabrielle St-Arnaud, Sébastien Lacroix, Sébastien Lacroix, Cyril Martin, Cyril Martin, Nicolas Flamand, Nicolas Flamand, Alain Veilleux, Alain Veilleux, Alain Veilleux, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Frédéric Raymond, Frédéric Raymond, Frédéric Raymond   +27 more
doaj   +2 more sources

The endocannabinoidome mediator N-oleoylglycine is a novel protective agent against 1-methyl-4-phenyl-pyridinium-induced neurotoxicity

Frontiers in Aging Neuroscience, 2022
N-oleoylglycine (OlGly) is a lipid mediator that belongs to the expanded version of the endocannabinoid (eCB) system, the endocannabinoidome (eCBome), which has recently gained increasing attention from the scientific community for its protective effects
Fabiana Piscitelli, Vincenzo Di Marzo, Fabio Arturo Iannotti   +2 more
exaly   +3 more sources