Results 41 to 50 of about 509 (127)

Beneficial Effects of Akkermansia muciniphila Are Not Associated with Major Changes in the Circulating Endocannabinoidome but Linked to Higher Mono-Palmitoyl-Glycerol Levels as New PPARα Agonists

Cells, 2021
Akkermansia muciniphila is considered as one of the next-generation beneficial bacteria in the context of obesity and associated metabolic disorders.
Clara Depommier, Rosa Maria Vitale, Fabio Arturo Iannotti, Cristoforo Silvestri, Nicolas Flamand, Céline Druart, Amandine Everard, Rudy Pelicaen, Dominique Maiter, Jean-Paul Thissen, Audrey Loumaye, Michel P. Hermans, Nathalie M. Delzenne, Willem M. de Vos, Vincenzo Di Marzo, Patrice D. Cani   +15 more
doaj   +1 more source

Spontaneous and Naloxone-Precipitated Withdrawal Behaviors From Chronic Opiates are Accompanied by Changes in N-Oleoylglycine and N-Oleoylalanine Levels in the Brain and Ameliorated by Treatment With These Mediators

Frontiers in Pharmacology, 2021
Rationale: The endocannabinoidome mediators, N-Oleoylglycine (OlGly) and N-Oleoylalanine (OlAla), have been shown to reduce acute naloxone-precipitated morphine withdrawal affective and somatic responses.Objectives: To determine the role and mechanism of
Samantha M. Ayoub, Fabiana Piscitelli, Cristoforo Silvestri, Cheryl L. Limebeer, Erin M. Rock, Reem Smoum, Mathew Farag, Hannah de Almeida, Megan T. Sullivan, Sébastien Lacroix, Besma Boubertakh, Nayudu Nallabelli, Aron H Lichtman, Francesco Leri, Raphael Mechoulam, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Linda A. Parker   +19 more
doaj   +1 more source

Successful and Unsuccessful Brain Aging in Pets: Pathophysiological Mechanisms behind Clinical Signs and Potential Benefits from Palmitoylethanolamide Nutritional Intervention

Animals, 2021
Canine and feline cognitive dysfunction syndrome is a common neurodegenerative disorder of old age and a natural model of human Alzheimer’s disease. With the unavoidable expanding life expectancy, an increasing number of small animals will be affected ...
Caterina Scuderi, Lorenzo Golini
doaj   +1 more source

Editorial: Insights on cannabinoid translational science and medicine: the endocannabinoidome as a target for clinical practice. [PDF]

Front Neurosci
Sampaio L, Campos RMP, Karhson D, Iannotti FA.   +3 more
europepmc   +4 more sources

Comparing Transgenic Production to Supplementation of ω-3 PUFA Reveals Distinct But Overlapping Mechanisms Underlying Protection Against Metabolic and Hepatic Disorders

Function, 2023
We compared endogenous ω-3 PUFA production to supplementation for improving obesity-related metabolic dysfunction. Fat-1 transgenic mice, who endogenously convert exogenous ω-6 to ω-3 PUFA, and wild-type littermates were fed a high-fat diet and a daily ...
Noëmie Daniel, Mélanie Le Barz, Patricia L Mitchell, Thibault V Varin, Isabelle Bourdeau Julien, Dominique Farabos, Geneviève Pilon, Josée Gauthier, Carole Garofalo, Jing X Kang, Jocelyn Trottier, Olivier Barbier, Denis Roy, Benoit Chassaing, Emile Levy, Frédéric Raymond, Antonin Lamaziere, Nicolas Flamand, Cristoforo Silvestri, Christian Jobin, Vincenzo Di Marzo, André Marette   +21 more
doaj   +1 more source

Mgll Knockout Mouse Resistance to Diet-Induced Dysmetabolism Is Associated with Altered Gut Microbiota

Cells, 2020
Monoglyceride lipase (MGLL) regulates metabolism by catabolizing monoacylglycerols (MAGs), including the endocannabinoid 2-arachidonoyl glycerol (2-AG) and some of its bioactive congeners, to the corresponding free fatty acids. Mgll knockout mice (Mgll−/−
Niokhor Dione, Sébastien Lacroix, Ulrike Taschler, Thomas Deschênes, Armita Abolghasemi, Nadine Leblanc, Vincenzo Di Marzo, Cristoforo Silvestri   +7 more
doaj   +1 more source

Crosstalk between Exercise-Derived Endocannabinoidome and Kynurenines: Potential Target Therapies for Obesity and Depression Symptoms

Pharmaceuticals, 2023
The kynurenine pathway (KP) and the endocannabinoid system (ECS) are known to be deregulated in depression and obesity; however, it has been recognized that acute physical exercise has an important modulating role inducing changes in the mobilization of ...
Tiffany Wences Chirino, Edgar Rangel López, Alexandra Luna Angulo, Paul Carrillo Mora, Carlos Landa Solis, María Alejandra Samudio Cruz, Alim C. Fuentes Bello, Rogelio Paniagua Pérez, Juan Ríos Martínez, Laura Sánchez Chapul   +9 more
doaj   +1 more source

Germ-free mice exhibit profound gut microbiota-dependent alterations of intestinal endocannabinoidome signaling

Journal of Lipid Research, 2020
The gut microbiota is a unique ecosystem of microorganisms interacting with the host through several biochemical mechanisms. The endocannabinoidome (eCBome), a complex signaling system including the endocannabinoid system, approximately 50 receptors and ...
Claudia Manca, Besma Boubertakh, Nadine Leblanc, Thomas Deschênes, Sebastien Lacroix, Cyril Martin, Alain Houde, Alain Veilleux, Nicolas Flamand, Giulio G. Muccioli, Frédéric Raymond, Patrice D. Cani, Vincenzo Di Marzo, Cristoforo Silvestri   +13 more
doaj   +1 more source

(Wh)olistic (E)ndocannabinoidome-Microbiome-Axis Modulation through (N)utrition (WHEN) to Curb Obesity and Related Disorders

Lipids in Health and Disease, 2022
The discovery of the endocannabinoidome (eCBome) is evolving gradually with yet to be elucidated functional lipid mediators and receptors. The diet modulates these bioactive lipids and the gut microbiome, both working in an entwined alliance.
Jyoti Sihag, Vincenzo Di Marzo
doaj   +1 more source

The Main Therapeutic Applications of Cannabidiol (CBD) and Its Potential Effects on Aging with Respect to Alzheimer’s Disease

Biomolecules, 2023
The use of cannabinoids (substances contained specifically in hemp plants) for therapeutic purposes has received increased attention in recent years.
Václav Trojan, Leoš Landa, Alexandra Šulcová, Jiří Slíva, Radovan Hřib   +4 more
doaj   +1 more source