Results 31 to 40 of about 509 (127)
The FEBS Journal, EarlyView.Circadian disruption via constant light induces sex‐specific remodeling of the microbiome, lipid mediators, and immune responses. Females exhibit broader gut microbiota alterations, reduced jejunal oxylipins, increased hypothalamic N‐acylethanolamines, and a more inflammatory cytokine profile. Muscle responses are sex‐ and fiber type‐dependent: females
Pejman A. Pashaki +7 more
wiley +2 more sources
Altered endocannabinoidome bioactive lipid levels accompany reduced DNBS-induced colonic inflammation in germ-free mice [PDF]
Lipids in Health and Disease, 2023 Background Gut microbiota are involved in the onset and development of chronic intestinal inflammation. The recently described endocannabinoidome (eCBome), a diverse and complex system of bioactive lipid mediators, has been reported to play a role in ...
Tommaso Venneri +6 more
doaj +2 more sources
Editorial: Exploring the interplay between microbiota, gut, and brain in inflammatory bowel disease [PDF]
Frontiers in NeurologyLe Liu
doaj +2 more sources
Editorial: Unravelling the role of CB2r in neuropsychiatric diseases [PDF]
Frontiers in Psychiatry, 2023 Emmanuel S. Onaivi
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Facile and Sustainable Synthesis of Commendamide and its Analogues
Frontiers in Chemistry, 2022 Commendamide, or N-(3-hydroxypalmitoyl)-glycine 1a, is a gut microbiota-derived bioactive metabolite, structurally similar to long-chain N-acyl-amino acids which belong to the complex lipid signaling system known as endocannabinoidome and play important ...
Rosaria Villano +3 more
doaj +1 more source
The endocannabinoidome in neuropsychiatry: Opportunities and potential risks
Pharmacological Research, 2021 The endocannabinoid system (ECS) comprises two cognate endocannabinoid receptors referred to as CB1R and CB2R. ECS dysregulation is apparent in neurodegenerative/neuro-psychiatric disorders including but not limited to schizophrenia, major depressive disorder and potentially bipolar disorder.
Gerwyn Morris +8 more
openaire +2 more sources
Modulatory role of the endocannabinoidome in the pathophysiology of the gastrointestinal tract
Pharmacological Research, 2022 Originating from Eastern Asia, the plant Cannabis sativa has been used for centuries as a medicinal treatment. The unwanted psychotropic effects of one of its major components, Δ9-tetrahydrocannabinol, discouraged its therapeutic employment until, recently, the discovery of cannabinoids receptors and their endogenous ligands endocannabinoids reignited ...
Lian J., Casari I., Falasca M.
openaire +3 more sources
Endocannabinoid basis of personality—Insights from animal model of social behavior
Frontiers in Pharmacology, 2023 Rationale: The endocannabinoid system is known to be involved in learning, memory, emotional processing and regulation of personality patterns. Here we assessed the endocannabinoid profile in the brains of mice with strong characteristics of social ...
Natalya M. Kogan +15 more
doaj +1 more source
Scientific Reports, 2022 The extended endocannabinoid system, also termed endocannabinoidome, participates in multiple metabolic functions in health and disease. Physical activity can both have an acute and chronic impact on endocannabinoid mediators, as does diet.
Fabiola Forteza +15 more
doaj +1 more source
Cells, 2021 Peroxisome proliferator-activated receptors (PPARs) are a family of nuclear receptors including PPARα, PPARγ, and PPARβ/δ, acting as transcription factors to regulate the expression of a plethora of target genes involved in metabolism, immune reaction ...
Fabio Arturo Iannotti, Rosa Maria Vitale
doaj +1 more source