Results 11 to 20 of about 509 (127)

Symphony of the gut microbiota and endocannabinoidome: a molecular and functional perspective [PDF]

Frontiers in Cellular and Infection Microbiology
This review examines the impact of interactions between the gut microbiota and the endocannabinoidome (eCBome) on health and disease, highlighting their significance for physiological and pathological processes.
Yang Wang, Jing Guo, Zhiqin Mao, Ying Chen   +3 more
doaj   +4 more sources

Deciphering the interaction between N-palmitoyl-D-glucosamine and the endocannabinoidome [PDF]

Scientific Reports
N-palmitoyl-D-glucosamine (PGA) belongs to the class of molecules known as Autacoid Local Injury Antagonism (ALIA)-amides, whose parent compound is N-palmitoyl-ethanolamine (PEA) an endocannabinoid-like mediator belonging to the expanded endocannabinoid ...
Aniello Schiano Moriello, Marco Allarà, Fabio Arturo Iannotti, Gabriele Marcolongo, Fabiana Piscitelli, Roberta Verde, Vincenzo Di Marzo, Stefania Petrosino   +7 more
doaj   +4 more sources

Circulating endocannabinoidome signatures of disease activity in amyotrophic lateral sclerosis. [PDF]

Eur J Neurol
Abstract Background and purpose Preclinical studies of amyotrophic lateral sclerosis (ALS) have shown altered endocannabinoid (eCB) signalling that may contribute to the disease. Results from human studies are sparse and inconclusive. The aim of this study was to determine the association between serum levels of eCBs or their congeners, the so‐called ...
Dubbioso R, Iannotti FA, Senerchia G, Verde R, Iuzzolino VV, Spisto M, Fasolino I, Manganelli F, Di Marzo V, Piscitelli F.   +9 more
europepmc   +6 more sources

Dietary food patterns as determinants of the gut microbiome–endocannabinoidome axis in humans [PDF]

Scientific Reports, 2023
The gut microbiota and the endocannabinoidome (eCBome) play important roles in regulating energy homeostasis, and both are closely linked to dietary habits. However, the complex and compositional nature of these variables has limited our understanding of
Sophie Castonguay-Paradis, Julie Perron, Nicolas Flamand, Benoît Lamarche, Frédéric Raymond, Vincenzo Di Marzo, Alain Veilleux   +6 more
doaj   +4 more sources

Targeting the Endocannabinoidome: A Novel Approach to Managing Extraintestinal Complications in Inflammatory Bowel Disease [PDF]

Pharmaceuticals
Background: Inflammatory bowel disease (IBD) is a chronic inflammatory disorder marked by persistent gastrointestinal inflammation and a spectrum of systemic effects, including extraintestinal manifestations (EIMs) that impact the joints, skin, liver ...
Dinesh Thapa, Anjali Ghimire, Leon N. Warne, Rodrigo Carlessi   +3 more
doaj   +4 more sources

The human milk endocannabinoidome is preserved by high hydrostatic pressure processing but altered by holder pasteurization [PDF]

Frontiers in Pediatrics
IntroductionThe microbiological safety of donor milk (DM) is commonly ensured by holder pasteurization (HoP, 62.5°C for 30 min) in human milk banks despite its detrimental effects on several bioactive factors.
Lucie Marousez, Elizabeth Dumais, Elizabeth Dumais, Léa Chantal Tran, Laure Dubernat, Marie De Lamballerie, Frédéric Gottrand, Frédéric Gottrand, Delphine Ley, Delphine Ley, Nicolas Flamand, Nicolas Flamand, Nicolas Flamand, Nicolas Flamand, Nicolas Flamand, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Vincenzo Di Marzo, Jean Lesage   +21 more
doaj   +4 more sources

Dietary iron interacts with diet composition to modulate the endocannabinoidome and the gut microbiome in mice [PDF]

Gut Microbiome
The endocannabinoidome (eCBome) and the gut microbiota have been implicated in diet-induced obesity and impaired metabolism. While the eCBome and the gut microbiome are known to respond to diet macronutrient composition, interaction with micronutrient ...
Fredy Alexander Guevara Agudelo, Nadine Leblanc, Isabelle Bourdeau-Julien, Gabrielle St-Arnaud, Fadil Dahhani, Nicolas Flamand, Alain Veilleux, Vincenzo Di Marzo, Frédéric Raymond   +8 more
doaj   +4 more sources

Editorial: Targeting the endocannabinoidome in neurodegenerative disorders [PDF]

Frontiers in Aging Neuroscience, 2023
Hiroki Ishiguro, Hiroki Ishiguro
doaj   +4 more sources

Investigating the alterations of endocannabinoidome signaling in the human small intestine in the context of obesity and type 2 diabetes [PDF]

Heliyon
Background: Human studies have linked obesity-related diseases, such as type-2 diabetes (T2D), to the modulation of endocannabinoid signaling. Cannabinoid CB1 and CB2 receptor activation by the endocannabinoids (eCBs) 2-arachidonoylglycerol (2-AG) and N ...
Volatiana Rakotoarivelo, Bénédicte Allam-Ndoul, Cyril Martin, Laurent Biertho, Vincenzo Di Marzo, Nicolas Flamand, Alain Veilleux   +6 more
doaj   +4 more sources

Reframing type 1 diabetes through the endocannabinoidome-microbiota axis: a systems biology perspective [PDF]

Frontiers in Endocrinology
Type 1 diabetes (T1D) has long been recognized as a T-cell-driven autoimmune disease. However, growing evidence highlights the involvement of metabolic, inflammatory, and gut microbiota-related factors in its progression. The endocannabinoid system (ECS),
Wojciech Łukowski
doaj   +4 more sources