The endocannabinoidome–gut microbiome–brain axis as a novel therapeutic target for autism spectrum disorder [PDF]
Journal of Biomedical ScienceIntroduction Autism spectrum disorder (ASD) is characterized by disruption of the gut–brain axis, which leads to behavioral, psychiatric, metabolic and gastrointestinal symptoms. Effective ASD treatments are limited.
Antonella Campanale +2 more
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Targeting the Endocannabinoidome in Pancreatic Cancer [PDF]
Biomolecules, 2022 Pancreatic Ductal adenocarcinoma (PDAC), the most common malignancy of the pancreas, is an aggressive and lethal form of cancer with a very high mortality rate.
Valerio Falasca, Marco Falasca
doaj +4 more sources
The Gut Microbiome–Endocannabinoidome Axis: A New Way of Controlling Metabolism, Inflammation, and Behavior [PDF]
Function, 2023 Cristoforo Silvestri, Vincenzo Di Marzo
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Biomedicines, 2021 Capsaicinoids, the pungent principles of chili peppers and prototypical activators of the transient receptor potential of the vanilloid type-1 (TRPV1) channel, which is a member of the expanded endocannabinoid system known as the endocannabinoidome ...
Cristoforo Silvestri +2 more
exaly +3 more sources
Neurobiological Processes Induced by Aerobic Exercise through the Endocannabinoidome [PDF]
Cells, 2021 Evidence suggesting the triangulation of the endocannabinoid system, exercise, and neurological health is emerging. In addition to the endocannabinoids N-arachidonoylethanolamine (anandamide; AEA) and 2-arachidonoylglycerol (2-AG), the expanded ...
Fabiola Forteza +2 more
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Synthesis of N-(3-Acyloxyacyl)glycines, Small Molecules with Potential Role in Gut Microbiome-Endocannabinoidome Communication [PDF]
MoleculesThe synthesis of some N-(3-acyloxyacyl)glycines, an interesting class of bioactive gut microbiota metabolites, is described. This procedure involves seven reaction steps using the commercially available Meldrum’s acid to obtain highly pure products, in ...
Rosaria Villano, Vincenzo Di Marzo
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Frontiers in Immunology, 2022 Omega-3 fatty acids support cardiometabolic health and reduce chronic low-grade inflammation. These fatty acids may impart their health benefits partly by modulating the endocannabinoidome and the gut microbiome, both of which are key regulators of ...
Cristoforo Silvestri +2 more
exaly +3 more sources
Dietary Manganese Modulates Microbiota and Intestinal N-Acylethanolamines in a Sex-Specific Manner in Mice With Diet-Induced Obesity. [PDF]
FASEB JFemale and male mice were fed manganese (Mn)‐depleted or Mn‐enriched diets in combination with either a low fat‐low sucrose (LFLS) or high fat‐high sucrose (HFHS) diet for 28 days. A sex‐specific metabolic response was observed under Mn‐depleted conditions, particularly affecting monoacylglycerol levels.
Agudelo FAG +8 more
europepmc +2 more sources
The diet rapidly and differentially affects the gut microbiota and host lipid mediators in a healthy population [PDF]
Microbiome, 2023 Background Bioactive lipids produced by human cells or by the gut microbiota might play an important role in health and disease. Dietary intakes are key determinants of the gut microbiota, its production of short-chain (SCFAs) and branched-chain fatty ...
Isabelle Bourdeau-Julien +8 more
doaj +2 more sources
N-eicosapentaenoyl-ethanolamine decreases the proliferation of psoriatic keratinocytes in a reconstructed psoriatic skin model [PDF]
Scientific Reports, 2023 Psoriasis is an inflammatory skin disease that is characterized by keratinocyte hyperproliferation, abnormal epidermal differentiation and dysregulated lipid metabolism.
Mélissa Simard +5 more
doaj +2 more sources