Results 111 to 120 of about 41,114 (259)

Core decompression augmented with bone marrow aspirate concentrate for refractory distal sesamoid bone pathology in horses: A retrospective clinical study

Veterinary Surgery, EarlyView.
Abstract Objective To determine short‐ and long‐term outcomes of core decompression combined with autologous bone marrow aspirate concentrate (BMAC) in treating moderate‐to‐severe refractory distal sesamoid bone (DSB) trabecular pathology in horses. Study design Retrospective observational study. Animals A total of 21 client‐owned Warmblood horses with
Grigorios Maleas, Mahmoud Mageed, Kristyna Hargitaiova   +2 more
wiley   +1 more source

Placebo and nocebo effects on pain through the lens of the predictive brain: Neurobiological mechanisms and translational implications

Experimental Physiology, EarlyView.
Abstract Placebo and nocebo effects on pain provide a model for investigating how cognitive and contextual factors modulate the physiological processes underlying nociception and its regulation. However, existing accounts remain fragmented and lack a unifying mechanistic framework linking brain, behaviour and autonomic responses.
Denisa Adina Zamfira, Tommaso Fassina, Kamil Zaworski, Elisa Carlino, Giacomo Rossettini   +4 more
wiley   +1 more source

Visualization of Endocannabinoids in the Cell

, 2016
A still unsolved, although critical, issue in endocannabinoid research is the mechanism by which the lipophilic compound anandamide (AEA) moves from its site of synthesis, crosses the aqueous milieu, and reaches the different intracellular compartments, where its metabolic and signaling pathways take place.
Oddi S, Totaro A, Maccarrone M
openaire   +2 more sources

Lysophospholipid G protein-coupled receptor binding parameters as determined by backscattering interferometry[S]

Journal of Lipid Research, 2019
Lysophosphatidic acid (LPA) activates cognate G protein-coupled receptors (GPCRs) to initiate biological signaling cascades. Lysophospholipid (LP) receptor binding properties remain incompletely assessed because of difficulties with ligand lipophilicity ...
Hirotaka Mizuno, Yasuyuki Kihara, Amanda Kussrow, Allison Chen, Manisha Ray, Richard Rivera, Darryl J. Bornhop, Jerold Chun   +7 more
doaj   +1 more source

Maternal obesity during lactation as a hypertensive cardiovascular risk factor in the offspring

Experimental Physiology, EarlyView.
Abstract Maternal obesity is a major public health concern, with growing evidence supporting its role in the developmental programming of cardiometabolic disease. Although prenatal mechanisms have been investigated extensively, the contribution of lactation as a postnatal window of cardiovascular (CV) programming remains insufficiently understood ...
Gabriela Arenas, Cristián A. Amador, Susana Contreras‐Duarte   +2 more
wiley   +1 more source

The endocannabinoid system drives neural progenitor proliferation

, 2005
The discovery of multipotent neural progenitor (NP) cells has provided strong support for the existence of neurogenesis in the adult brain. However, the signals controlling NP proliferation remain elusive. Endocannabinoids, the endogenous counterparts of
Monory, K, Stella, Nephi, Aguado, T., Palazuelos, J, Marsicano, Giovanni, Galve Roperh, Ismael, Guzman, M., Palazuelos Diego, Javier, Guzman, M, Aguado, T, Cravatt, B., Cravatt, B, Monory, Krisztina, Kokaia, Zaal,, Galve-Roperh, I., Cravatt, Benjamin, Kokaia, Z., Monory, K., Lutz, B., Lutz, B, Guzmán Pastor, Manuel, Galve-Roperh, I, Stella, N, Stella, N., Marsicano, G, Lutz, Beat, Kokaia, Zaal, Marsicano, G., Aguado Sánchez, Tania, Palazuelos, J., Lund University.   +30 more
core   +1 more source

Polarized cellular patterns of endocannabinoid production and detection shape cannabinoid signaling in neurons

Frontiers in Cellular Neuroscience, 2015
Neurons display important differences in plasma membrane composition between somatodendritic and axonal compartments, potentially leading to currently unexplored consequences in G-protein-coupled-receptor signaling.
Delphine eLadarre, Delphine eLadarre, Alexandre B. Roland, Alexandre B. Roland, Stephane eBiedzinski, Stephane eBiedzinski, Ana eRicobaraza, Ana eRicobaraza, Zsolt eLenkei, Zsolt eLenkei   +9 more
doaj   +1 more source

Protective effect of cannabinoid type 2 receptor agonist (JWH‐133) against hepatotoxicity induced by Prangos ferulacea Lindl. extract

Experimental Physiology, EarlyView.
Abstract This study investigated Prangos ferulacea (PF)‐induced hepatotoxicity, its potential association with endoplasmic reticulum (ER) stress and proinflammatory cytokines, and the effect of the cannabinoid type 2 receptor agonist JWH‐133. Rats (n = 37) were divided into four groups: control–sham group (CSG, n = 9), PF extract group (PG, n = 9), PF ...
Mesut Çelik, Aslı Çetin Taşlıdere, Zeynal Mete Karaca, Halil Düzova, İbrahim Halil Geçibesler, Ali Rıza Çalişkan, Çağatay Taşkapan, Kübranur Korkmaz   +7 more
wiley   +1 more source

Cannabinoid exposure during pregnancy: Cardiorespiratory effects and offspring outcomes

The Journal of Physiology, EarlyView.
Abstract figure legend Prenatal exposure to cannabinoids has been investigated across human and animal studies to understand its impact on physiological development. Evidence suggests that early‐life cannabinoid exposure influence multiple developmental processes, extending beyond neurodevelopmental outcomes to potentially affect placental function ...
Luis Gustavo A. Patrone, Luciane H. Gargaglioni   +1 more
wiley   +1 more source

Δ9 Tetrahydrocannabinol and cannabis extracts differentially improve adipoinsular dysfunction in diet‐induced obesity

The Journal of Physiology, EarlyView.
Abstract figure legend THC and extract administered to diet‐induced obese mice reduced body weight and fat storage. Extract, but not THC, improved glucose clearance by a mechanism that may include restoring adipoinsular function. Abstract Diet‐induced obesity (DIO) is associated with dysregulated adipoinsular axis and endocannabinoid system (eCBS ...
Bryant Avalos, Martin Olmos, Courtney P. Wood, Camila Alvarez, Haley M. Read, Parima Udompholkul, Theodore Garland Jr, Nicholas V. DiPatrizio   +7 more
wiley   +1 more source