Results 121 to 130 of about 54,731 (237)
Endocannabinoids and Immunity [PDF]
Cannabis and Cannabinoid Research, 2016 Over the last 10 years, a great boost of knowledge accumulated on the immunomodulatory and anti-inflammatory properties of endocannabinoids (eCBs). In this scenario, these bioactive lipids, which are produced by most immune cells along with a set of receptors and enzymes that regulate their synthesis and degradation, act as secondary modulators and ...
openaire +2 more sources
Phytotherapy Research, Volume 40, Issue 5, Page 2604-2631, May 2026.Schematic overview of the proposed neuromodulatory actions of linalool in Alzheimer's disease. Through multi‐target effects on oxidative stress, amyloid aggregation, GABAergic and glutamatergic signaling, linalool may restore excitatory/inhibitory balance.
Ilaria Piccialli +4 more
wiley +1 more source
Behavioral and pharmacological characterization of a mouse model of palatable diet alternation [PDF]
, 2017 Obesity and eating disorders represent a severe problem in Western societies. Both the increased availability of highly palatable foods and dieting are major risk factors contributing to the epidemic disorders of feeding. The purpose of this study was to
Schlain, Gabrielle Star
core
Addiction, Volume 121, Issue 5, Page 1179-1189, May 2026.Abstract Aims To describe differences in the expression of genes encoding cannabinoid receptors (CNR1, CNR2), the associated receptor GRP55 and the enzymes fatty acid amide hydrolase (FAAH) and monoacylglycerol lipase (MGLL) between individuals with alcohol use disorder (AUD) and controls in key mesocorticolimbic brain regions.
María Salud García‐Gutiérrez +5 more
wiley +1 more source
New Insights into Cannabis Consumption; Abuses and Possible Therapeutic Effects [PDF]
, 2015 Cannabis is one of the oldest psychotropic drugs known to humanity. The paper assesses the current knowledge on the cannabis, including the mechanisms of action and the therapeutic potential of cannabinoids.
Baconi, Daniela Luiza +2 more
core +3 more sources
British Journal of Pharmacology, Volume 183, Issue 9, Page 1747-1778, May 2026.Cardiac remodelling and fibrosis after myocardial infarction or during chronic diseases, such as arterial and pulmonary hypertension or diabetes mellitus, continue to be the more important prognostic factors in determining survival, and so the search for effective anti‐fibrotic interventions is an important target for research and therapy in cardiology.
Anna Krzyżewska +2 more
wiley +1 more source
Rapid improvement of renal microcirculatory homeostasis by liraglutide following diabetes induction
Diabetes, Obesity and Metabolism, Volume 28, Issue 5, Page 4066-4081, May 2026.Abstract Aims Renal microvascular dysfunction is a central driver of diabetic kidney disease, yet the potential for rapid therapeutic reversal remains obscure. We investigated the effect of short‐term liraglutide on early changes in the renal microcirculation post‐induction of diabetes.
Yuan Li +8 more
wiley +1 more source
Review: “The Disappointment Dilemma: Short‐ and Long‐Term Learning From Negative Outcomes”
European Journal of Neuroscience, Volume 63, Issue 9, May 2026.The habenula routes negative‐outcome signals to VTA, RMTg, and IPN to shape aversive learning and motivation. The lateral habenula encodes acute negative prediction errors to rapidly adapt behavior to threat, fear, and avoidance. The medial habenula integrates repeated stress, drug, and aversive experiences into long‐term negative mood and expectations.
Ines Ibañez‐Tallon +4 more
wiley +1 more source
Role of the endocannabinoid system in extinction of fear memories: lessons from animal studies
European Journal of Psychotraumatology, 2012 Rationale : Generalized avoidance belongs to the core symptoms of a variety of anxiety disorders such as panic disorder or posttraumatic stress disorder. However, therapy for avoidance behavior still bears many obstacles.
Carsten T. Wotjak
doaj +1 more source
Headache: The Journal of Head and Face Pain, Volume 66, Issue 5, Page 1181-1192, May 2026.Abstract Objective To highlight key factors required to optimize multi‐mechanistic approaches with oral combination treatments for the acute management of a migraine attack. Background Given the complex multi‐factorial nature of migraine, combining treatments with different mechanisms of action should improve outcomes compared to monotherapies, but ...
Stephen Silberstein, Alan M. Rapoport
wiley +1 more source