Results 131 to 140 of about 37,091 (247)

Cannabinoids and the endocannabinoid system in liver diseases

Cannabinoids are biologically active substances acting via feedback-coupled CB1 and CB2 receptors. Their expression in myofibroblasts and liver endothelial cells is reported to be elevated in chronic liver diseases. The effect of CB1 receptor stimulation
Anna Parfieniuk-Kowerda, Aleksandra Andrzejuk, Robert Flisiak, Diana Martonik, Aleksander Tarasik   +4 more
core   +1 more source

Heterogeneous metabolic response of endothelial cells from different vascular beds to experimental hyperglycaemia and metformin

The Journal of Physiology, Volume 604, Issue 11, Page 4208-4224, 1 June 2026.
Abstract figure legend Diabetes mellitus is associated with vascular pathology that leads to vascular complications in several tissues, such as retinopathy of the eye. Endothelial dysfunction plays a pivotal role in the progression of each complication.
C. McAleese, G. Joudah, I. P. Salt, J. R. Petrie, J. M. Leiper, Laura B. Dowsett   +5 more
wiley   +1 more source

Untersuchungen zur Rolle des endogenen Cannabinoidsystems bei der Anpassung an aversive Situationen

, 2006
Ziel der vorliegenden Arbeit war es zu untersuchen, auf welche Art und Weise das endogene Cannabinoidsystem die Extinktion konditionierter Furcht vermittelt. Dabei gliedert sich diese Arbeit in vier Teile.
Kamprath, Kornelia
core  

Endocannabinoid pathway.

, 2016
Endocannabinoid pathway giving rise to prostaglandins glycerol esters, prostaglandins and prostamides.
D. Kvaskoff (2141107), G. E. Rice (2141116), K. Vaswani (2141113), M. D. Mitchell (2141104), H. N. Peiris (2141110)   +4 more
core   +1 more source

The endogenous cannabinoid system gates plasticity of tonic GABA inhibition

The Journal of Physiology, Volume 604, Issue 12, Page 4984-5010, 15 June 2026.
Abstract figure legend Postsynaptic depolarisation and increases in intracellular Ca2+ ([Ca2+]i) trigger the synthesis of endocannabinoids (eCBs), which are hypothesised to enhance tonic GABAergic inhibition via two primary pathways. In the proposed autocrine mechanism, eCBs activate postsynaptic somatodendritic or mitochondrial CB1 receptors ...
Roberto Colangeli, Fiorenzo Conti
wiley   +1 more source

Investigating Runner’s High: Changes in Mood and Endocannabinoid Concentrations after a 60 min Outdoor Run Considering Sex, Running Frequency, and Age

Sports
Runner’s high is a euphoric emotional state occurring during and post-physical exercise. Although previous data indicate endocannabinoids’ involvement in animal runner’s high, their role in human runner’s high remains to be established.
Theresia Weiermair, Eva Svehlikova, Beate Boulgaropoulos, Christoph Magnes, Anita Eberl   +4 more
doaj   +1 more source

CMR‐derived left ventricular pressure‐volume loops enhance individualized assessment of disease severity and prognosis in pulmonary arterial hypertension in adults

Physiological Reports, Volume 14, Issue 11, June 2026.
Abstract In pulmonary arterial hypertension (PAH), increased pulmonary vascular resistance (PVR) causes right ventricular pressure overload and left ventricular (LV) underfilling. We investigated LV mechanics and their prognostic value in PAH using cardiovascular magnetic resonance (CMR)‐derived LV pressure‐volume (PV) loops.
Alessandro Castiglione, Elsa Bergström, Barbro Kjellström, Göran Rådegran, Håkan Arheden, Ellen Ostenfeld   +5 more
wiley   +1 more source

Molecular Fingerprint of Endocannabinoid Signaling in the Developing Paraventricular Nucleus of the Hypothalamus as Revealed by Single-Cell RNA-Seq and In Situ Hybridization

Cells
The paraventricular nucleus of the hypothalamus (PVN) regulates, among others, the stress response, sexual behavior, and energy metabolism through its magnocellular and parvocellular neurosecretory cells.
Evgenii O. Tretiakov, Zsófia Hevesi, Csenge Böröczky, Alán Alpár, Tibor Harkany, Erik Keimpema   +5 more
doaj   +1 more source

New Cannabinoid receptor type 1 and 2 agonists and applications to understanding the endocannabinoid system: A chemical approach

, 2023
The modulation of the endocannabinoid system by synthetic ligands has allowed mediating several pathophysiological processes in the control of various diseases. The work of many chemists in designing drugs that activate cannabinoid receptors type I (CB1R)
Faúndez Parraguez, Manuel Ignacio
core  

High Relevance of Fatty Acid Oxidation in a Migrating Mammal, the Nathusius' Pipistrelle (Pipistrellus nathusii)

The FASEB Journal, Volume 40, Issue 10, 31 May 2026.
Bats can sustain powered flight, but their reliance on fatty acid oxidation may limit long‐distance migration compared to birds. Using untargeted metabolomics, we analyzed blood metabolites of Nathusius' pipistrelle under controlled flight and migratory field conditions to identify fuel use.
Alesia Walker, Thuy Thanh Truong, Martin Klingenspor, Anders Hedenström, Gunars Pētersons, Philippe Schmitt‐Kopplin, Shannon E. Currie, Christian C. Voigt   +7 more
wiley   +1 more source