Results 101 to 110 of about 37,091 (247)

Multi‐Targeting Ligands as Prospective Therapeutics for Alzheimer's Disease, a Prevalent Neurodegenerative Disorder: Mechanistic Insights, Emerging Targets and Drug Discovery Campaigns

Medicinal Research Reviews, Volume 46, Issue 4, Page 1173-1229, July 2026.
ABSTRACT Alzheimer's disease (AD) is a debilitating neurodegenerative condition characterized by progressive cognitive impairment, memory deterioration, and neuronal dysfunction. Its complex pathophysiology involves multiple interlinked processes, including amyloid‐β (Aβ) aggregation, tau hyperphosphorylation, oxidative stress, neuroinflammation ...
Amandeep Thakur, Mandeep Rana, Sakshi Vanjani, Kei‐Chi Liou, Rajeev Taliyan, Kunal Nepali, Chih‐Hao Yang   +6 more
wiley   +1 more source

Anandamide Inhibits Vascular Smooth Muscle Migration, Endothelial Adhesion Protein Expression and Monocyte Adhesion of Human Coronary Artery Cells

Cells
Endocannabinoids have been shown to play a complex role in the pathophysiology of a number of cardiovascular disorders. In the present study, the effects of the two major endocannabinoids anandamide (AEA) and 2-arachidonoylglycerol (2-AG) were ...
Elane Blessing, Elisa Teichmann, Burkhard Hinz   +2 more
doaj   +1 more source

Endogenous Cannabinoid Production in the Rat Female Reproductive Tract Is Regulated by Changes in the Hormonal Milieu

Pharmaceuticals, 2011
The endogenous cannabinoid (eCB) system is emerging as an important component of female reproductive tract physiology. The eCBs anandamide (AEA), 2-arachidonoyl glycerol (2-AG), and N-arachidonoyl glycine (NAGly) were measured in the rat reproductive ...
Cassandra Allard, Heather B. Bradshaw
doaj   +1 more source

Az endocannabinoid rendszer szerepének vizsgálata humán verejtékmirigy sejtek különböző élettani folyamatainak szabályozására

, 2009
Az endocannabinoid rendszer fontos szerepet tölt be számos élettani folyamat szabályozásában. Így az endogén cannabinoid vegyületek fokozzák az NCL-SG3 sejtek differenciálódását valamint azok zsírosodását.gjmolekuláris biológusrégi ...
Fodor, Angéla
core  

The endocannabinoid system drives neural progenitor proliferation

, 2005
The discovery of multipotent neural progenitor (NP) cells has provided strong support for the existence of neurogenesis in the adult brain. However, the signals controlling NP proliferation remain elusive. Endocannabinoids, the endogenous counterparts of
Monory, K, Stella, Nephi, Aguado, T., Palazuelos, J, Marsicano, Giovanni, Galve Roperh, Ismael, Guzman, M., Palazuelos Diego, Javier, Guzman, M, Aguado, T, Cravatt, B., Cravatt, B, Monory, Krisztina, Kokaia, Zaal,, Galve-Roperh, I., Cravatt, Benjamin, Kokaia, Z., Monory, K., Lutz, B., Lutz, B, Guzmán Pastor, Manuel, Galve-Roperh, I, Stella, N, Stella, N., Marsicano, G, Lutz, Beat, Kokaia, Zaal, Marsicano, G., Aguado Sánchez, Tania, Palazuelos, J., Lund University.   +30 more
core   +1 more source

Short‐Term Daily Oral Administration of Cannabidiol Does Not Impact Rebound Tonometry Intraocular Pressure or Schirmer Tear Test Values in Healthy Adult Horses

Veterinary Ophthalmology, Volume 29, Issue 4, July 2026.
ABSTRACT Objective To assess the effect of orally administered cannabidiol (CBD) on TonoVet measured intraocular pressure (IOP) and Schirmer tear test I (STT) in horses. Animal Studied Horse. Procedure This was a masked, randomized, balanced cross‐over study of six healthy adult horses.
Kathryn Diehl, Colleen Sheridan, Rachel Reed   +2 more
wiley   +1 more source

Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women

, 2010
N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake.
Hendriks, H.F.J., Balvers, M.G.J., Joosten, M.M., Witkamp, R.F., Verhoeckx, K.C.M.   +4 more
core   +1 more source

Don't Sweat It: Cannabinoid CB1 Receptors Reduce Sweating in a Mouse Model

The FASEB Journal, Volume 40, Issue 12, 30 June 2026.
A new galvanic skin response‐based approach offers a simple method for measuring sweating in the paws of mice. This method is used to demonstrate that cannabinoid CB1 receptors reduce baseline sweating in mice, likely via inhibition of sympathetic acetylcholine release via axonal CB1 receptors.
Natalia Murataeva, Joseph Youkilis, Yogith Rao, Alex Straiker   +3 more
wiley   +1 more source

Cannabigerol Alleviates Obesity‐Induced Mitochondrial Dysfunction by Cardiolipin Fatty Acid Remodeling

The FASEB Journal, Volume 40, Issue 11, 15 June 2026.
Graphical overview of the effects of the high‐fat, high‐sucrose (HFHS) diet regime and 2‐week cannabigerol (CBG) treatment on the intramuscular long‐chain fatty acids (LCFAs) trafficking and lipid metabolism, with subsequent implications for mitochondrial cardiolipin (CL) composition in the red gastrocnemius muscle.
Patrycja Bielawiec, Karolina Konstantynowicz‐Nowicka, Adrian Chabowski, Ewa Harasim‐Symbor   +3 more
wiley   +1 more source

Dandruff Is a Low‐Grade Inflammatory Condition Featuring Hyperproliferative Keratinocytes, Interleukin‐17‐Producing T Cells, and N‐Acyl Ethanolamines

Immunity, Inflammation and Disease, Volume 14, Issue 6, June 2026.
ABSTRACT Background Dandruff features epidermal scaling but lacks overt signs of inflammation, such as erythema. Characterisation of its inflammatory profile may improve understanding of the underlying inflammatory mechanisms and therefore indicate alternative approaches for treatment.
Alexandra C. Kendall, Karishma Mohamed, Holly Linley, Marta M. Koszyczarek, Anne Chandidzura, Christopher E. M. Griffiths, Tracy Hussell, Amy E. Saunders, Anna Nicolaou   +8 more
wiley   +1 more source