Results 31 to 40 of about 41,114 (259)

Changes of endocannabinoid plasma levels following type I trauma [PDF]

, 2012
The endocannabinoid system has emerged as one of the most important facilitators of stress adaptation in the body. So far, little to no research took place concerning the endocannabinoid response to stress in humans.
Heimendahl, Jenny von
core   +1 more source

Oral Ultramicronized Palmitoylethanolamide: Plasma and Tissue Levels and Spinal Anti-hyperalgesic Effect

Frontiers in Pharmacology, 2018
Palmitoylethanolamide (PEA) is a pleiotropic lipid mediator with established anti-inflammatory and anti-hyperalgesic activity. Ultramicronized PEA (PEA-um) has superior oral efficacy compared to naïve (non-micronized) PEA.
Stefania Petrosino, Stefania Petrosino, Marika Cordaro, Roberta Verde, Aniello Schiano Moriello, Aniello Schiano Moriello, Gabriele Marcolongo, Carlo Schievano, Rosalba Siracusa, Fabiana Piscitelli, Alessio F. Peritore, Rosalia Crupi, Daniela Impellizzeri, Emanuela Esposito, Salvatore Cuzzocrea, Vincenzo Di Marzo   +15 more
doaj   +1 more source

Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]

, 2012
Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Andres Beiras Fernandez, Roland Toth, Markus Giehl, Weis, Florian, Erich Kilger, Beiras-Fernandez, Andres, Campolongo, Patrizia, Giehl, Markus, Schelling, Gustav, Florian Weis, Strewe, Claudia, Toth, Roland, Mirjam Schopp, Gustav Schelling, Daniela Hauer, Kilger, Erich, Schopp, Mirjam, Hauer, Daniela, Claudia Strewe   +18 more
core   +1 more source

Enhanced Anandamide Plasma Levels in Patients with Complex Regional Pain Syndrome following Traumatic Injury: A Preliminary Report [PDF]

, 2009
The complex regional pain syndrome (CRPS) is a disabling neuropathic pain condition that may develop following injuries of the extremities. The pathogenesis of this syndrome is not clear; however, it includes complex interactions between the nervous and ...
Schelling, G., Huge, V., Kaufmann, I., G. Schelling, Campolongo, P., Thiel, M., V. Huge, M. Vogeser, Vogeser, M., CAMPOLONGO, Patrizia, I. Kaufmann, Hauer, D., A. Chouker, M. Thiel, Chouker, A., D. Hauer   +15 more
core   +1 more source

Endocannabinoid system and pregnancy [PDF]

Reproduction, 2016
Abstract The endocannabinoid system (eCS), is a complex system, comprising the main endogenous ligands anandamide and 2-arachidonoyl glycerol, the cannabinoid receptors CB1 and CB2 and the biosynthetic and degrading enzymes. Cumulative evidence shows that the eCS plays an important role in reproduction, from egg fertilization to ...
Correa, Fernando Gabriel, Wolfson, Manuel Luis, Valchi, Paula, Aisemberg, Julieta, Franchi, Ana Maria   +4 more
openaire   +3 more sources

Differential Cannabinoid Receptor Expression during Reactive Gliosis: a Possible Implication for a Nonpsychotropic Neuroprotection

The Scientific World Journal, 2009
Activated microglia and astrocytes produce a large number of inflammatory and neurotoxic substances in various brain pathologies, above all during neurodegenerative disorders.
Daniele De Filippis, Antonio Steardo, Alessandra D'Amico, Caterina Scuderi, Mariateresa Cipriano, Giuseppe Esposito, Teresa Iuvone   +6 more
doaj   +1 more source

Orexin-A Prevents Lipopolysaccharide-Induced Neuroinflammation at the Level of the Intestinal Barrier

Frontiers in Endocrinology, 2019
In states of intestinal dysbiosis, a perturbation of the normal microbiome composition, the intestinal epithelial barrier (IEB) permeability is increased as a result of the disruption of the epithelial tight junction protein network, in which occludin is
Lea Tunisi, Lea Tunisi, Nicola Forte, Alba Clara Fernández-Rilo, Isabella Mavaro, Isabella Mavaro, Raffaele Capasso, Livia D'Angelo, Livia D'Angelo, Nataša Milić, Luigia Cristino, Vincenzo Di Marzo, Vincenzo Di Marzo, Letizia Palomba, Letizia Palomba   +14 more
doaj   +1 more source

Endocannabinoids and Immunity [PDF]

Cannabis and Cannabinoid Research, 2016
Over the last 10 years, a great boost of knowledge accumulated on the immunomodulatory and anti-inflammatory properties of endocannabinoids (eCBs). In this scenario, these bioactive lipids, which are produced by most immune cells along with a set of receptors and enzymes that regulate their synthesis and degradation, act as secondary modulators and ...
openaire   +2 more sources

Assay of Endocannabinoid Uptake [PDF]

, 2016
Endocannabinoids at physiological concentrations are crossing cellular membranes by facilitated diffusion, a process that can be studied by measuring transport kinetics.
Gertsch, Jürg, Rau, Mark, Chicca, Andrea, Nicolussi, Simon   +3 more
core   +2 more sources

Anandamide Metabolites Protect against Seizures through the TRP Channel Water Witch in Drosophila melanogaster

Cell Reports, 2020
Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
doaj   +1 more source