Results 21 to 30 of about 41,114 (259)

The orexigenic effect of ghrelin is mediated through central activation of the endogenous cannabinoid system [PDF]

, 2008
INTRODUCTION: Ghrelin and cannabinoids stimulate appetite, this effect possibly being mediated by the activation of hypothalamic AMP-activated protein kinase (AMPK), a key enzyme in appetite and metabolism regulation. The cannabinoid receptor type 1 (CB1)
Judith Harvey-White, Francesca Lolli, Farkas, I., Amin, F., Mirjam Christ-Crain, Kola, Blerina, Fekete, Csaba, George Kunos, Kola, B., Faisal Amin, A. B. Grossman, M. Korbonits, Blerina Kola, Liposits, Zsolt, G. Kunos, Ashley B Grossman, B. Kola, Amin, F, Gábor Wittmann, Kunos, George, Christ-Crain, M, Farkas, Imre, Lolli, F, Zsolt Liposits, Lolli, F., F. Amin, Farkas, I, Christ-Crain, M., Korbonits, M., I. Farkas, Grossman, AB, C. Fekete, Kola, B, Harvey-White, J., Wittmann, Gábor, Korbonits, Márta, G. Wittmann, Harvey-White, J, Fekete, C, Harvey-White, Judith, Márta Korbonits, Imre Farkas, Liposits, Z, Z. Liposits, Grossman, Ashley B., Ashley B. Grossman, Wittmann, G., Christ-Crain, Mirjam, Amin, Faisal, Lolli, Francesca, Liposits, Z., M. Christ Crain, J. Harvey White, Fekete, C., Korbonits, M, Kunos, G., Csaba Fekete, Grossman, A. B., Kunos, G, Wittmann, G   +59 more
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Effects of parabolic flight and spaceflight on the endocannabinoid system in humans [PDF]

, 2012
The endocannabinoid system (ECS) plays an important role in the regulation of physiological functions, from stress and memory regulation to vegetative control and immunity.
Feuerecker, Matthias, Strewe, Claudia, Schelling, Gustav, Morukov, Boris, Chouker, Alexander, Nichiporuk, Igor, Kaufmann, Ines, Hauer, Daniela   +7 more
core   +1 more source

Endocannabinoid Overload [PDF]

Molecular Pharmacology, 2010
The signaling capacity of endogenous cannabinoids ("endocannabinoids") is tightly regulated by degradative enzymes. This Perspective highlights a research article in this issue (p. 996) in which the authors show that genetic disruption of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol (2 ...
Aron H, Lichtman, Jacqueline L, Blankman, Benjamin F, Cravatt   +2 more
openaire   +2 more sources

Palmitoylethanolamide counteracts substance P-induced mast cell activation in vitro by stimulating diacylglycerol lipase activity

Journal of Neuroinflammation, 2019
Background Palmitoylethanolamide (PEA) is a pleiotropic endogenous lipid mediator currently used as a “dietary food for special medical purposes” against neuropathic pain and neuro-inflammatory conditions.
Stefania Petrosino, Aniello Schiano Moriello, Roberta Verde, Marco Allarà, Roberta Imperatore, Alessia Ligresti, Ali Mokhtar Mahmoud, Alessio Filippo Peritore, Fabio Arturo Iannotti, Vincenzo Di Marzo   +9 more
doaj   +1 more source

Assay of Endocannabinoid Uptake. [PDF]

, 2023
Endocannabinoids at nanomolar physiological concentrations cross cellular membranes by facilitated diffusion, a process that can be studied by measuring transport kinetics and endocannabinoid trafficking employing radioligands and mass spectrometry. Here,
Gertsch, Jürg, Rau, Mark, Chicca, Andrea, Reynoso-Moreno, Ines, Nicolussi, Simon   +4 more
core   +1 more source

Metabolism of endocannabinoids

Postępy Higieny i Medycyny Doświadczalnej, 2016
Endocannabinoids belong to a group of ester, ether and amide derivatives of fatty acids, which are endogenous ligands of receptors CB1, CB2, TRPV1 and GPR55 that are included in the endocannabinoid system of the animal organism. The best known endocannabinoids are: N-arachidonylethanolamide called anandamide (AEA) and 2-arachidonoylglycerol (2-AG ...
Michał, Biernacki, Elżbieta, Skrzydlewska   +1 more
openaire   +2 more sources

Molecular components and functions of the endocannabinoid system in mouse prefrontal cortex. [PDF]

PLoS ONE, 2007
Cannabinoids have deleterious effects on prefrontal cortex (PFC)-mediated functions and multiple evidences link the endogenous cannabinoid (endocannabinoid) system, cannabis use and schizophrenia, a disease in which PFC functions are altered. Nonetheless,
Mathieu Lafourcade, Izaskun Elezgarai, Susana Mato, Yamina Bakiri, Pedro Grandes, Olivier J Manzoni   +5 more
doaj   +1 more source

Pitfalls in measuring the endocannabinoid 2-arachidonoyl glycerol in biological samples [PDF]

, 2007
Background: The endocannabinoid 2-arachidonoyl glycerol (2-AG) undergoes spontaneous isomerization to biologically inactive 1-AG. This effect has not been adequately addressed in previous studies that reported 2-AG concentrations in biological samples ...
Schelling, Gustav, Vogeser, Michael
core   +1 more source

2-Arachidonoylglycerol as an Endogenous Cue Negatively Regulates Attachment of the Mussel Perna viridis

Frontiers in Marine Science, 2021
Endocannabinoids play important roles in the functioning of various physiological systems in humans and non-mammalian animals, including invertebrates.
Qi Dai, Zhi-Xuan Wang, Yan-Qing Sheng, Zhi-Wen Wu, Yan Qiu, Pei Su, Cai-Huan Ke, Dan-Qing Feng   +7 more
doaj   +1 more source

Intrinsic up-regulation of 2-AG favors an area specific neuronal survival in different in vitro models of neuronal damage [PDF]

, 2012
BACKGROUND: The endocannabinoid 2-arachidonoyl glycerol (2-AG) acts as a retrograde messenger and modulates synaptic signaling e. g. in the hippocampus. 2-AG also exerts neuroprotective effects under pathological situations.
Geisslinger, Gerd, Gerd Geisslinger, Nowicki, Marcin, Ziebell, Simone, Hobusch, Constance, Koch, Marco, Gerd Geisslinger (109814), Dehghani, Faramarz, Marcin Nowicki (109802), Ingo Bechmann (109810), Faramarz Dehghani (109822), Sonja Kallendrusch, Simone Ziebell (109806), Faramarz Dehghani, Bechmann, Ingo, Ehrlich, Angela, Simone Ziebell, Marco Koch (109817), Angela Ehrlich, Sonja Kallendrusch (109796), Constance Hobusch (109798), Constance Hobusch, Ingo Bechmann, Kallendrusch, Sonja, Bechmann, Ingo Jürgen, Marcin Nowicki, Marco Koch, Angela Ehrlich (109799)   +27 more
core   +2 more sources