Results 11 to 20 of about 41,114 (259)

Targeting gut dysbiosis against inflammation and impaired autophagy in Duchenne muscular dystrophy

EMBO Molecular Medicine, 2023
Nothing is known about the potential implication of gut microbiota in skeletal muscle disorders. Here, we provide evidence that fecal microbiota composition along with circulating levels of short‐chain fatty acids (SCFAs) and related metabolites are ...
Hilal Kalkan, Ester Pagano, Debora Paris, Elisabetta Panza, Mariarosaria Cuozzo, Claudia Moriello, Fabiana Piscitelli, Armita Abolghasemi, Elisabetta Gazzerro, Cristoforo Silvestri, Raffaele Capasso, Andrea Motta, Roberto Russo, Vincenzo Di Marzo, Fabio Arturo Iannotti   +14 more
doaj   +1 more source

Synthesis, characterization, and application of gold nanostars for the identification of 2-Arachidonoyl glycerol [PDF]

مجله پزشکی دانشگاه علوم پزشکی تبریز, 2022
Background. The endocannabinoid system (ECS) is a complex of neurotransmitters in the central nervous system (CNS) and plays a key role in regulating cognitive and physiological processes.
Fereshteh Kohansal, Ahmad Mobed, Mohammad Hasanzadeh, Ali Ahmadalipour, Nasrin Shadjou   +4 more
doaj   +1 more source

Endocannabinoids and exercise [PDF]

British Journal of Sports Medicine, 2004
Exercise induces changes in mental status, particularly analgesia, sedation, anxiolysis, and a sense of wellbeing. The mechanisms underlying these changes remain unknown. Recent findings show that exercise increases serum concentrations of endocannabinoids, suggesting a possible explanation for a number of these changes.
A, Dietrich, W F, McDaniel
openaire   +2 more sources

Role of 2-Arachidonoyl-Glycerol and CB1 Receptors in Orexin-A-Mediated Prevention of Oxygen–Glucose Deprivation-Induced Neuronal Injury

Cells, 2020
Orexin-A (OX-A) protects the brain against oxidative stress-mediated ischemic injury. Since the endocannabinoid 2-arachidonoylglycerol (2-AG) and cannabinoid type-1 (CB1) receptors were previously shown to mediate some of the effects of OX-A exerted ...
Letizia Palomba, Andrea Motta, Roberta Imperatore, Fabiana Piscitelli, Raffaele Capasso, Federica Mastroiacovo, Giuseppe Battaglia, Valeria Bruno, Luigia Cristino, Vincenzo Di Marzo   +9 more
doaj   +1 more source

Endocannabinoid-Mediated Control of Neural Circuit Excitability and Epileptic Seizures

Frontiers in Neural Circuits, 2022
Research on endocannabinoid signaling has greatly advanced our understanding of how the excitability of neural circuits is controlled in health and disease.
Yuki Sugaya, Yuki Sugaya, Masanobu Kano, Masanobu Kano   +3 more
doaj   +1 more source

The Microbiome and Gut Endocannabinoid System in the Regulation of Stress Responses and Metabolism

Frontiers in Cellular Neuroscience, 2022
The endocannabinoid system, with its receptors and ligands, is present in the gut epithelium and enteroendocrine cells, and is able to modulate brain functions, both indirectly through circulating gut-derived factors and directly through the vagus nerve,
Raj Kamal Srivastava, Beat Lutz, Beat Lutz, Inigo Ruiz de Azua   +3 more
doaj   +1 more source

Endocannabinoid Turnover [PDF]

, 2017
In this review, we consider the biosynthetic, hydrolytic, and oxidative metabolism of the endocannabinoids anandamide and 2-arachidonoylglycerol. We describe the enzymes associated with these events and their characterization. We identify the inhibitor profile for these enzymes and the status of therapeutic exploitation, which to date has been limited ...
Fowler, Christopher J., Doherty, Patrick, Alexander, Stephen P.H.   +2 more
openaire   +4 more sources

The Epigenetics of the Endocannabinoid System [PDF]

International Journal of Molecular Sciences, 2020
The endocannabinoid system (ES) is a cell-signalling system widely distributed in biological tissues that includes endogenous ligands, receptors, and biosynthetic and hydrolysing machineries. The impairment of the ES has been associated to several pathological conditions like behavioural, neurological, or metabolic disorders and infertility, suggesting
Meccariello Rosaria, Santoro Antonietta, DʹAngelo Stefania, Morrone Rossella, Fasano Silvia, Viggiano Andrea, Pierantoni Riccardo   +6 more
openaire   +2 more sources

Motion sickness, stress and the endocannabinoid system [PDF]

, 2010
A substantial number of individuals are at risk for the development of motion sickness induced nausea and vomiting (N&V) during road, air or sea travel.
Kreth Simone, Feuerecker, Matthias, Matthias Feuerecker, Ines Kaufmann, Kaufmann, Ines, Kreth, Simone, Thieme, Detlef, Thieme Detlef, Choukèr Alexander, Schelling Gustav, Feuerecker Matthias, Michael Vogeser, Kaufmann Ines, Vogeser Michael, Manfred Thiel, Schelling, Gustav, Vogeser, Michael, Choukèr, Alexander, Detlef Thieme, Thiel, Manfred, Gustav Schelling, Alexander Choukèr, Daniela Hauer, Thiel Manfred, Hauer, Daniela, Simone Kreth, Hauer Daniela   +26 more
core   +2 more sources

Quantification of the density of cooperative neighboring synapses required to evoke endocannabinoid signaling [PDF]

, 2014
The spatial pattern of synapse activation may impact on synaptic plasticity. This applies to the synaptically-evoked endocannabinoid-mediated short-term depression at the parallel fiber (PF) to Purkinje cell synapse, the occurrence of which requires ...
Pachoud, B, Bergerot, A, Pachoud, B., Knöpfel, T, Sharma, P, Marcaggi, P, Bergerot, A., Marcaggi, P., Sharma, P., Marcaggi, Païkan, Knöpfel, T.   +10 more
core   +1 more source