Results 21 to 30 of about 12,113 (164)

Peripheral Endogenous Cannabinoid Levels Are Increased in Schizophrenia Patients Evaluated in a Psychiatric Emergency Setting

Frontiers in Psychiatry, 2020
BackgroundThe endogenous cannabinoid system mediates the psychoactive effects of cannabis in the brain. It has been argued that this system may play a key role in the pathophysiology of schizophrenia.
Stéphane Potvin, Stéphane Potvin, Louiza Mahrouche, Roxane Assaf, Roxane Assaf, Marjolaine Chicoine, Charles-Édouard Giguère, Alexandra Furtos, Roger Godbout, Roger Godbout   +9 more
doaj   +1 more source

Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain

Molecules, 2021
The cannabinoid system is independently affected by stress and chronic ethanol exposure. However, the extent to which co-occurrence of traumatic stress and chronic ethanol exposure modulates the cannabinoid system remains unclear.
Veronica M. Piggott, Scott C. Lloyd, James I. Matchynski, Shane A. Perrine, Alana C. Conti   +4 more
doaj   +1 more source

Time-Dependent Vascular Effects of Endocannabinoids Mediated by Peroxisome Proliferator-Activated Receptor Gamma (PPAR𝛾)

PPAR Research, 2009
The aim of the present study was to examine whether endocannabinoids cause PPAR𝛾-mediated vascular actions. Functional vascular studies were carried out in rat aortae. Anandamide and N-arachidonoyl-dopamine (NADA), but not palmitoylethanolamide, caused
Saoirse E. O'Sullivan, David A. Kendall, Michael D. Randall   +2 more
doaj   +1 more source

Binding of anandamide to bovine serum albumin

Journal of Lipid Research, 2003
The endocannabinoid anandamide is of lipid nature and may thus bind to albumin in the vascular system, as do fatty acids. The knowledge of the free water-phase concentration of anandamide is essential for the investigations of its transfer from the ...
Inge N. Bojesen, Harald S. Hansen
doaj   +1 more source

Inhibition by Anandamide of 6-Hydroxydopamine-Induced Cell Death in PC12 Cells

International Journal of Cell Biology, 2010
6-hydroxydopamine (6-OHDA) is a selective neurotoxin that is widely used to investigate cell death and protective strategies in models of Parkinson's disease.
Katarzyna Mnich, David P. Finn, Eilis Dowd, Adrienne M. Gorman   +3 more
doaj   +1 more source

Effect of Anandamide on Erythrocyte Survival [PDF]

Cellular Physiology and Biochemistry, 2007
The endocannabinoid anandamide (Arachidonylethanolamide, AEA) is known to induce apoptosis in a wide variety of nucleated cells. The present study explored whether anandamide induces suicidal death of erythrocytes or eryptosis, which is characterized by cell shrinkage and cell membrane scrambling with phosphatidylserine exposure at the erythrocyte ...
Peter J, Bentzen, Florian, Lang
openaire   +2 more sources

Anandamide Induces Endothelium-Dependent Vasoconstriction and CGRPergic Nerve–Mediated Vasodilatation in the Rat Mesenteric Vascular Bed

Journal of Pharmacological Sciences, 2012
An endogenous cannabinoid anandamide (N-arachidonoylethanolamide) has been shown to cause vasodilatation in vitro and a brief vasoconstriction followed by prolonged depressor response in vivo.
Chihiro Tamaki, Hideki Nawa, Shingo Takatori, Sakiko Oda, Toshiaki Sendo, Yoshito Zamami, Hiromu Kawasaki   +6 more
doaj   +1 more source

Pitfalls and solutions in assaying anandamide transport in cells[S]

Journal of Lipid Research, 2010
Nonspecific binding of anandamide to plastic exhibits many features that could be mistaken as biological processes, thereby representing an important source of conflicting data on the uptake and release of this lipophilic substance. Herein, we propose an
Sergio Oddi, Filomena Fezza, Giuseppina Catanzaro, Chiara De Simone, Mariangela Pucci, Daniele Piomelli, Alessandro Finazzi-Agrò, Mauro Maccarrone   +7 more
doaj   +1 more source

Dose-response effects of systemic anandamide administration in mice sequentially submitted to the open field and elevated plus-maze tests

Brazilian Journal of Medical and Biological Research, 2009
The endocannabinoid system is involved in the control of many physiological functions, including the control of emotional states. In rodents, previous exposure to an open field increases the anxiety-like behavior in the elevated plus-maze.
A. Ribeiro, V. Ferraz-de-Paula, M.L. Pinheiro, J. Palermo-Neto   +3 more
doaj   +1 more source

Effects of endocannabinoids in pentylenetetrazole induced seizures in mice

Acta Medica Alanya, 2020
Aim: Pentylenetetrazole (PTZ) is an agent widely used for the assessment of putative anticonvulsant drugs and is supposed to induce repetitive firing of nerve fibers as well as shorten the refractory period.
Engin Yücel, Zühal Aktuna, İ̇smail Semih Keski̇l   +2 more
doaj   +1 more source