Results 21 to 30 of about 17,707 (220)

Anandamide reduces intracellular Ca2+ concentration through suppression of Na+/Ca2+ exchanger current in rat cardiac myocytes. [PDF]

PLoS ONE, 2013
PURPOSE:Anandamide, one of the endocannabinoids, has been reported to exhibit cardioprotective properties, particularly in its ability to limit the damage produced by ischemia reperfusion injury. However, the mechanisms underlying the effect are not well
Qian Li, Na Cui, Yuanjie Du, Huijie Ma, Yi Zhang   +4 more
doaj   +1 more source

Interaction between anandamide and sphingosine-1-phosphate in mediating vasorelaxation in rat coronary artery [PDF]

, 2010
<b>BACKGROUND AND PURPOSE</b> Anandamide and sphingosine-1-phosphate (S1P) both regulate vascular tone in a variety of vessels. This study aimed to examine the mechanisms involved in the regulation of coronary vascular tone by anandamide and ...
Kane, K.A., Brett, R.R., Mair, K.M., Kennedy, S., Pyne, N.J., Pyne, S., Robinson, E.   +6 more
core   +1 more source

The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. [PDF]

PLoS ONE, 2015
The endocannabinoid system is expressed in bone, although its role in the regulation of bone growth is controversial. Many studies have examined the effect of endocannabinoids directly on osteoclast function, but few have examined their role in human ...
Marie Smith, Richard Wilson, Sally O'Brien, Cristina Tufarelli, Susan I Anderson, Saoirse Elizabeth O'Sullivan   +5 more
doaj   +1 more source

Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation [PDF]

Journal of Lipid Research, 2008
Anandamide (N-arachidonoylethanolamide; AEA) acts as an endogenous agonist of both cannabinoid and vanilloid receptors. During the last two decades, its metabolic pathways and biological activity have been investigated extensively and relatively well characterized.
Sergio Oddi, Enrico Dainese, Monia Di Tommaso, Monia Di Tommaso, Nicoletta Pasquariello, Chiara De Simone, Filomena Fezza, Cinzia Rapino, Mauro Maccarrone, Alessandro Finazzi-Agrò   +9 more
openaire   +6 more sources

Formation of prostamides from anandamide in FAAH knockout mice analyzed by HPLC with tandem mass spectrometry

Journal of Lipid Research, 2004
We investigated the formation of PGF2α 1-ethanolamide, PGE2 1-ethanolamide, and PGD2 1-ethanolamide (prostamides F2α, E2, and D2, respectively) in liver, lung, kidney, and small intestine after a single intravenous bolus administration of 50 mg/kg of ...
Allan Weber, Jinsong Ni, Kah-Hiing John Ling, Andrew Acheampong, Diane D-S. Tang-Liu, Robert Burk, Benjamin F. Cravatt, David Woodward   +7 more
doaj   +1 more source

Glucocorticoid-endocannabinoid interaction in cardiac surgical patients: relationship to early cognitive dysfunction and late depression [PDF]

, 2012
Background: Endocannabinoids (ECs) are rapidly acting immune-modulatory lipid-signaling molecules that are important for adaptation to stressful and aversive situations. They are known to interact with glucocorticoids and other stress-responsive systems.
Andres Beiras Fernandez, Roland Toth, Markus Giehl, Weis, Florian, Erich Kilger, Beiras-Fernandez, Andres, Campolongo, Patrizia, Giehl, Markus, Schelling, Gustav, Florian Weis, Strewe, Claudia, Toth, Roland, Mirjam Schopp, Gustav Schelling, Daniela Hauer, Kilger, Erich, Schopp, Mirjam, Hauer, Daniela, Claudia Strewe   +18 more
core   +1 more source

Serum contents of endocannabinoids are correlated with blood pressure in depressed women. [PDF]

, 2012
BACKGROUND: Depression is known to be a risk factor for cardiovascular diseases but the underlying mechanisms remain unclear. Since recent preclinical evidence suggests that endogenous agonists of cannabinoid receptors (endocannabinoids) are involved in ...
Ho, WS V, Miller, GE, Hillard, CJ, Ho WS Vanessa, WS Vanessa Ho, Hillard, Cecilia J., Gorzalka, Boris B., Miller, Gregory E, Hill Matthew N, Hillard Cecilia J, Hill, MN, Gorzalka, Boris B, Gregory E Miller, Hill, Matthew N, Miller Gregory E, Hillard, Cecilia J, Ho, Vanessa, Miller, Gregory E., Matthew N Hill, Gorzalka, BB, Boris B Gorzalka, Cecilia J Hillard, Hill, Matthew N., Gorzalka Boris B, Ho, WS   +24 more
core   +1 more source

Effect of an unstirred layer on the membrane permeability of anandamide

Journal of Lipid Research, 2006
To study the effect of an unstirred layer (UL), we have investigated the exchange efflux kinetics of anandamide at 0°C, pH 7.3, from albumin-free as well as from albumin-filled human red blood cell ghosts to media of various BSA concentrations ([BSA]o ...
Inge N. Bojesen, Harald S. Hansen
doaj   +1 more source

Effects of cannabidiol on anandamide levels in individuals with cannabis use disorder: findings from a randomised clinical trial for the treatment of cannabis use disorder

Translational Psychiatry, 2023
Cannabidiol (CBD) has shown promise in treating psychiatric disorders, including cannabis use disorder – a major public health burden with no approved pharmacotherapies. However, the mechanisms through which CBD acts are poorly understood.
Daniel Ying-Heng Hua, Chandni Hindocha, Gianluca Baio, Rachel Lees, Natacha Shaban, Celia J. Morgan, Ali Mofeez, H. Valerie Curran, Tom P. Freeman   +8 more
doaj   +1 more source

Plasma anandamide concentrations are lower in children with autism spectrum disorder

Molecular Autism, 2018
Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication.
Debra S. Karhson, Karolina M. Krasinska, Jamie Ahloy Dallaire, Robin A. Libove, Jennifer M. Phillips, Allis S. Chien, Joseph P. Garner, Antonio Y. Hardan, Karen J. Parker   +8 more
doaj   +1 more source