Anandamide and vanilloid TRPV1 receptors [PDF]
British Journal of Pharmacology, 2003 A large body of evidence now exists to substantiate that the endocannabinoid, anandamide, activates TRPV1 receptors. It is a low intrinsic efficacy TRPV1 agonist that behaves as a partial agonist in tissues with a low receptor reserve, while in tissues with high receptor reserve and in circumstances associated with certain disease states, it behaves as
R. Ross
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Role of FAAH-like anandamide transporter in anandamide inactivation.
PLoS ONE, 2013 The endocannabinoid system modulates numerous physiological processes including nociception and reproduction. Anandamide (AEA) is an endocannabinoid that is inactivated by cellular uptake followed by intracellular hydrolysis by fatty acid amide hydrolase
Kwannok Leung +4 more
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Release of anandamide from blood cells [PDF]
Clinical Chemistry and Laboratory Medicine (CCLM), 2006 Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Bisogno +30 more
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Exploiting nanotechnologies and TRPV1 channels to investigate the putative anandamide membrane transporter. [PDF]
PLoS ONE, 2010 Considerable efforts have been made to characterize the pathways regulating the extracellular levels of the endocannabinoid anandamide. However, none of such pathways has been so argued as the existence of a carrier-mediated transport of anandamide ...
Alessia Ligresti +10 more
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The endogenous lipid anandamide is a full agonist at the human vanilloid receptor (hVR1)
British Journal of Pharmacology, 2000 D. Smart +8 more
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High-fat diet-induced insulin resistance does not increase plasma anandamide levels or potentiate anandamide insulinotropic effect in isolated canine islets. [PDF]
PLoS ONE, 2015 BACKGROUND:Obesity has been associated with elevated plasma anandamide levels. In addition, anandamide has been shown to stimulate insulin secretion in vitro, suggesting that anandamide might be linked to hyperinsulinemia.
Orison O Woolcott +18 more
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The insertion and transport of anandamide in synthetic lipid membranes are both cholesterol-dependent. [PDF]
PLoS ONE, 2009 Anandamide is a lipid neurotransmitter which belongs to a class of molecules termed the endocannabinoids involved in multiple physiological functions. Anandamide is readily taken up into cells, but there is considerable controversy as to the nature of ...
Eric Di Pasquale +3 more
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Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese Zucker rats. [PDF]
PLoS ONE, 2013 Impaired vascular function, manifested by an altered ability of the endothelium to release endothelium-derived relaxing factors and endothelium-derived contracting factors, is consistently reported in obesity.
Nubia S Lobato +8 more
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A Closer Look at Anandamide Interaction With TRPV1
Frontiers in Molecular Biosciences, 2020 The transient receptor potential subfamily vanilloid type 1 ion channel (TRPV1), located in the peripheral nervous system has been implicated in the perception of pain and possesses the ability to be modulated by various cannabinoid ligands.
Chanté Muller +3 more
semanticscholar +1 more source
Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines. [PDF]
PLoS ONE, 2012 Mammalian spermatozoa are not able to fertilize an egg immediately upon ejaculation. They acquire this ability during their transit through the female genital tract in a process known as capacitation.
Claudia Osycka-Salut +6 more
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