Results 11 to 20 of about 12,113 (164)
Biomolecules, 2018 Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and absence of an ionisable group for ...
Coralie Di Scala +4 more
doaj +1 more source
A biosynthetic pathway for anandamide [PDF]
Proceedings of the National Academy of Sciences, 2006 The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released “on demand” by neurons in the brain. Anandamide is also generated by macrophages where its endotoxin (LPS)-induced synthesis has been implicated in the hypotension of septic shock and advanced liver cirrhosis.
Jie, Liu +10 more
openaire +2 more sources
Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation. [PDF]
PLoS ONE, 2011 Anandamide (AEA), a major endocannabinoid, binds to cannabinoid and vanilloid receptors (CB1, CB2 and TRPV1) and affects many reproductive functions.
María Gracia Gervasi +7 more
doaj +1 more source
Characterization of biotin-anandamide, a novel tool for the visualization of anandamide accumulation [PDF]
Journal of Lipid Research, 2008 Anandamide (N-arachidonoylethanolamide; AEA) acts as an endogenous agonist of both cannabinoid and vanilloid receptors. During the last two decades, its metabolic pathways and biological activity have been investigated extensively and relatively well characterized.
Sergio Oddi +9 more
openaire +6 more sources
Anandamide reduces intracellular Ca2+ concentration through suppression of Na+/Ca2+ exchanger current in rat cardiac myocytes. [PDF]
PLoS ONE, 2013 PURPOSE:Anandamide, one of the endocannabinoids, has been reported to exhibit cardioprotective properties, particularly in its ability to limit the damage produced by ischemia reperfusion injury. However, the mechanisms underlying the effect are not well
Qian Li +4 more
doaj +1 more source
The Effects of the Endocannabinoids Anandamide and 2-Arachidonoylglycerol on Human Osteoblast Proliferation and Differentiation. [PDF]
PLoS ONE, 2015 The endocannabinoid system is expressed in bone, although its role in the regulation of bone growth is controversial. Many studies have examined the effect of endocannabinoids directly on osteoclast function, but few have examined their role in human ...
Marie Smith +5 more
doaj +1 more source
Journal of Lipid Research, 2004 We investigated the formation of PGF2α 1-ethanolamide, PGE2 1-ethanolamide, and PGD2 1-ethanolamide (prostamides F2α, E2, and D2, respectively) in liver, lung, kidney, and small intestine after a single intravenous bolus administration of 50 mg/kg of ...
Allan Weber +7 more
doaj +1 more source
Effect of an unstirred layer on the membrane permeability of anandamide
Journal of Lipid Research, 2006 To study the effect of an unstirred layer (UL), we have investigated the exchange efflux kinetics of anandamide at 0°C, pH 7.3, from albumin-free as well as from albumin-filled human red blood cell ghosts to media of various BSA concentrations ([BSA]o ...
Inge N. Bojesen, Harald S. Hansen
doaj +1 more source
Translational Psychiatry, 2023 Cannabidiol (CBD) has shown promise in treating psychiatric disorders, including cannabis use disorder – a major public health burden with no approved pharmacotherapies. However, the mechanisms through which CBD acts are poorly understood.
Daniel Ying-Heng Hua +8 more
doaj +1 more source
Plasma anandamide concentrations are lower in children with autism spectrum disorder
Molecular Autism, 2018 Background Autism spectrum disorder (ASD) is a neurodevelopmental disorder characterized by restricted, stereotyped behaviors and impairments in social communication.
Debra S. Karhson +8 more
doaj +1 more source