Results 11 to 20 of about 17,707 (220)
Cell Reports, 2020 Summary: Endocannabinoids protect against seizures, but their mechanism of action is still unclear, as they can have effects independent of known cannabinoid receptors. Using Drosophila melanogaster, which lacks canonical cannabinoid receptors, we report
Jack A. Jacobs, Amita Sehgal
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Reduced endothelium-dependent relaxation to anandamide in mesenteric arteries from young obese Zucker rats. [PDF]
PLoS ONE, 2013 Impaired vascular function, manifested by an altered ability of the endothelium to release endothelium-derived relaxing factors and endothelium-derived contracting factors, is consistently reported in obesity.
Nubia S Lobato +8 more
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Anandamide induces sperm release from oviductal epithelia through nitric oxide pathway in bovines. [PDF]
PLoS ONE, 2012 Mammalian spermatozoa are not able to fertilize an egg immediately upon ejaculation. They acquire this ability during their transit through the female genital tract in a process known as capacitation.
Claudia Osycka-Salut +6 more
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Toward an anandamide transporter [PDF]
Proceedings of the National Academy of Sciences, 2005 Almost every step in the elucidation of the structure and mechanism of action of the endocannabinoid system has been plagued by controversy. Although the psychoactive component of marijuana was identified in the mid-1960s (1), it took another two decades to show that it does not act by an unspecific mechanism, but via receptors, now known as the ...
Raphael, Mechoulam, Dale G, Deutsch
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Release of anandamide from blood cells [PDF]
, 2006 Background: Endogenous ligands of cannabinoid receptors ( endocannabinoids), in particular anandamide ( arachidonylethanolamide), have been recognized as being of crucial importance in a variety of physiological functions.
Storr, Martin +5 more
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Biomolecules, 2018 Anandamide is a lipid neurotransmitter derived from arachidonic acid, a polyunsaturated fatty acid. The chemical differences between anandamide and arachidonic acid result in a slightly enhanced solubility in water and absence of an ionisable group for ...
Coralie Di Scala +4 more
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A biosynthetic pathway for anandamide [PDF]
Proceedings of the National Academy of Sciences, 2006 The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released “on demand” by neurons in the brain. Anandamide is also generated by macrophages where its endotoxin (LPS)-induced synthesis has been implicated in the hypotension of septic shock and advanced liver cirrhosis.
Jie, Liu +10 more
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Enhanced Anandamide Plasma Levels in Patients with Complex Regional Pain Syndrome following Traumatic Injury: A Preliminary Report [PDF]
, 2009 The complex regional pain syndrome (CRPS) is a disabling neuropathic pain condition that may develop following injuries of the extremities. The pathogenesis of this syndrome is not clear; however, it includes complex interactions between the nervous and ...
Schelling, G. +15 more
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Anandamide capacitates bull spermatozoa through CB1 and TRPV1 activation. [PDF]
PLoS ONE, 2011 Anandamide (AEA), a major endocannabinoid, binds to cannabinoid and vanilloid receptors (CB1, CB2 and TRPV1) and affects many reproductive functions.
María Gracia Gervasi +7 more
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Plasma anandamide and other N-acylethanolamines are correlated with their corresponding free fatty acid levels under both fasting and non-fasting conditions in women [PDF]
, 2010 N-acylethanolamines (NAEs), such as anandamide (AEA), are a group of endogenous lipids derived from a fatty acid linked to ethanolamine and have a wide range of biological activities, including regulation of metabolism and food intake.
Hendriks, H.F.J. +4 more
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