Results 41 to 50 of about 17,707 (220)
Effects of endocannabinoids in pentylenetetrazole induced seizures in mice
Acta Medica Alanya, 2020 Aim: Pentylenetetrazole (PTZ) is an agent widely used for the assessment of putative anticonvulsant drugs and is supposed to induce repetitive firing of nerve fibers as well as shorten the refractory period.
Engin Yücel +2 more
doaj +1 more source
Anandamide and noladin ether prevent neurotoxicity of the human amyloid-ß peptide
, 2002 Cannabinoid receptor agonists including anandamide and noladin either have recently been suggested to exhibit neuroprotective properties. The amyloid-β (Aβ) peptide is thought to be responsible for the neurodegenerative changes associated with Alzheimer ...
Milton, N.G.N.
core +1 more source
Membrane transport of anandamide through resealed human red blood cell membranes
Journal of Lipid Research, 2005 The use of resealed red blood cell membranes (ghosts) allows the study of the transport of a compound in a nonmetabolizing system with a biological membrane.
Inge N. Bojesen, Harald S. Hansen
doaj +1 more source
Addiction, EarlyView.Abstract Aim Our primary aim was to conduct a network meta‐analysis (NMA) for the effectiveness, safety and acceptability of all psychosocial interventions and all pharmacotherapies for cannabis use disorder (CUD). Methods We conducted a NMA of studies identified from two completed systematic reviews examining the effectiveness, safety and ...
Monika Halicka +6 more
wiley +1 more source
Decreased circulating anandamide levels in preeclampsia [PDF]
, 2015 The endocannabinoid system plays a key role in female reproduction, including implantation, decidualization and placentation. A growing number of studies indicate that placental and peripheral blood anandamide levels correlate closely with both ...
Walentin S +13 more
core +1 more source
Endocannabinoid System in Pregnancy Maintenance and Labor: A Mini-Review
Frontiers in Endocrinology, 2021 The endocannabinoid system (ECS) is a cell-signaling system present in multiple organ systems and is an integral part of sustaining the microenvironment necessary for early pregnancy success and maintenance.
Melissa L. Kozakiewicz +2 more
doaj +1 more source
Is there a role for cannabidiol in obesity, metabolic syndrome and binge eating?
British Journal of Pharmacology, EarlyView.Cannabidiol (CBD) is one of the most abundant phytocannabinoids isolated from the Cannabis sativa plant. CBD is a lipophilic, non‐intoxicating substance that differently from Δ9‐tetrahydrocannabinol (Δ9‐THC) does not present the typical profile of a drug of abuse.
Luca Botticelli +7 more
wiley +1 more source
Journal of Pharmacological Sciences, 2012 Cannabinoid agonists impair hippocampus-dependent learning and memory. Using mouse hippocampal slice preparations, we examined the effect of anandamide, an endogenous cannabinoid, on sharp wave–ripple (SW-R) complexes, which are believed to mediate ...
Yi Sun +4 more
doaj +1 more source
Frontiers in Molecular Neuroscience, 2023 Transient receptor potential ion channel, vanilloid subfamily, type 1 (TRPV1) cation channel, and cannabinoid receptor 1 (CB1) are essential in the modulation of nociceptive signaling in the spinal cord dorsal horn that underlies different pathological ...
Diana Spicarova +7 more
doaj +1 more source
Novel approaches for drug development against chronic primary pain: A systematic review
British Journal of Pharmacology, EarlyView.Abstract Chronic primary pain (CPP) persisting for more than 3 months, associated with significant emotional distress without any known underlying cause, is an unmet medical need. Traditional or adjuvant analgesics do not provide satisfactory pain relief for a great proportion of these patients.
Valéria Tékus +5 more
wiley +1 more source