Results 41 to 50 of about 31,279 (264)

Peripheral Endogenous Cannabinoid Levels Are Increased in Schizophrenia Patients Evaluated in a Psychiatric Emergency Setting

Frontiers in Psychiatry, 2020
BackgroundThe endogenous cannabinoid system mediates the psychoactive effects of cannabis in the brain. It has been argued that this system may play a key role in the pathophysiology of schizophrenia.
Stéphane Potvin, Stéphane Potvin, Louiza Mahrouche, Roxane Assaf, Roxane Assaf, Marjolaine Chicoine, Charles-Édouard Giguère, Alexandra Furtos, Roger Godbout, Roger Godbout   +9 more
doaj   +1 more source

Traumatic Stress, Chronic Ethanol Exposure, or the Combination, Alter Cannabinoid System Components in Reward and Limbic Regions of the Mouse Brain

Molecules, 2021
The cannabinoid system is independently affected by stress and chronic ethanol exposure. However, the extent to which co-occurrence of traumatic stress and chronic ethanol exposure modulates the cannabinoid system remains unclear.
Veronica M. Piggott, Scott C. Lloyd, James I. Matchynski, Shane A. Perrine, Alana C. Conti   +4 more
doaj   +1 more source

N-acylethanolamines, anandamide and food intake [PDF]

Biochemical Pharmacology, 2009
Anandamide and the other N-acylethanolamines, e.g. oleoylethanolamide (OEA), palmitoylethanolamide (PEA), and linoleoylethanolamide (LEA), may be formed by several enzymatic pathways from their precursors, which are the N-acylated ethanolamine phospholipids.
Hansen, Harald S, Diep, Thi Ai
openaire   +4 more sources

Time-Dependent Vascular Effects of Endocannabinoids Mediated by Peroxisome Proliferator-Activated Receptor Gamma (PPAR𝛾)

PPAR Research, 2009
The aim of the present study was to examine whether endocannabinoids cause PPAR𝛾-mediated vascular actions. Functional vascular studies were carried out in rat aortae. Anandamide and N-arachidonoyl-dopamine (NADA), but not palmitoylethanolamide, caused
Saoirse E. O'Sullivan, David A. Kendall, Michael D. Randall   +2 more
doaj   +1 more source

Inhibition by Anandamide of 6-Hydroxydopamine-Induced Cell Death in PC12 Cells

International Journal of Cell Biology, 2010
6-hydroxydopamine (6-OHDA) is a selective neurotoxin that is widely used to investigate cell death and protective strategies in models of Parkinson's disease.
Katarzyna Mnich, David P. Finn, Eilis Dowd, Adrienne M. Gorman   +3 more
doaj   +1 more source

Binding of anandamide to bovine serum albumin

Journal of Lipid Research, 2003
The endocannabinoid anandamide is of lipid nature and may thus bind to albumin in the vascular system, as do fatty acids. The knowledge of the free water-phase concentration of anandamide is essential for the investigations of its transfer from the ...
Inge N. Bojesen, Harald S. Hansen
doaj   +1 more source

Cannabis sativa and the endogenous cannabinoid system: therapeutic potential for appetite regulation [PDF]

, 2011
The herb Cannabis sativa (C. sativa) has been used in China and on the Indian subcontinent for thousands of years as a medicine. However, since it was brought to the UK and then the rest of the western world in the late 19th century, its use has been a ...
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core   +3 more sources

Metabolite profiling identifies anandamide as a biomarker of nonalcoholic steatohepatitis.

JCI Insight, 2017
The discovery of metabolite-phenotype associations may highlight candidate biomarkers and metabolic pathways altered in disease states. We sought to identify novel metabolites associated with obesity and one of its major complications, nonalcoholic fatty
W. T. Kimberly, J. O’Sullivan, Anjali K. Nath, M. Keyes, Xu Shi, M. Larson, Qiong Yang, M. Long, R. Vasan, R. Peterson, Thomas J. Wang, K. Corey, R. Gerszten   +12 more
semanticscholar   +1 more source

A biosynthetic pathway for anandamide [PDF]

Proceedings of the National Academy of Sciences, 2006
The endocannabinoid arachidonoyl ethanolamine (anandamide) is a lipid transmitter synthesized and released “on demand” by neurons in the brain. Anandamide is also generated by macrophages where its endotoxin (LPS)-induced synthesis has been implicated in the hypotension of septic shock and advanced liver cirrhosis.
Jie, Liu, Lei, Wang, Judith, Harvey-White, Douglas, Osei-Hyiaman, Raj, Razdan, Qian, Gong, Andrew C, Chan, Zhifeng, Zhou, Bill X, Huang, Hee-Yong, Kim, George, Kunos   +10 more
openaire   +2 more sources

Anandamide Induces Endothelium-Dependent Vasoconstriction and CGRPergic Nerve–Mediated Vasodilatation in the Rat Mesenteric Vascular Bed

Journal of Pharmacological Sciences, 2012
An endogenous cannabinoid anandamide (N-arachidonoylethanolamide) has been shown to cause vasodilatation in vitro and a brief vasoconstriction followed by prolonged depressor response in vivo.
Chihiro Tamaki, Hideki Nawa, Shingo Takatori, Sakiko Oda, Toshiaki Sendo, Yoshito Zamami, Hiromu Kawasaki   +6 more
doaj   +1 more source