Results 211 to 220 of about 30,487 (240)

Human ether-a-go-go-related (HERG) gene and ATP-sensitive potassium channels as targets for adverse drug effects

Pharmacology & Therapeutics, 2006
Torsades de pointes (TdP) arrhythmia is a potentially fatal form of ventricular arrhythmia that occurs under conditions where cardiac repolarization is delayed (as indicated by prolonged QT intervals from electrocardiographic recordings). A likely mechanism for QT interval prolongation and TdP arrhythmias is blockade of the rapid component of the ...
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Artificial channels for confined mass transport at the sub-nanometre scale

Nature Reviews Materials, 2021
Jie Shen, Gong-Ping Liu, Yu Han
exaly  

Large-conductance Ca(2+)-activated potassium and ether-a-go-go potassium channels regulate proliferation of human mesenchymal stem cells

2010
Poster Presentation: abstract no ...
Li, GR, Zhang, YY, Tse, HF, Lau, CP
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β-Arrestin-Mediated Regulation of the Human Ether-a-go-go-Related Gene (hERG) Potassium Channel

2016
The human ether-a-go-go-related gene (hERG) encodes the voltage-gated K+ channel, hERG (Kv11.1). This channel passes the rapidly-activating delayed rectifier K+ current (IKr), which is important for cardiac repolarization. A reduction in IKr due to loss-of-function mutations or drug interactions causes long QT syndrome (LQTS), which can lead to cardiac
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Water in Nanopores and Biological Channels: A Molecular Simulation Perspective

Chemical Reviews, 2020
Charlotte I Lynch, Shanlin Rao, Mark S P Sansom   +2 more
exaly  

Inhibition of Human Ether-A-Go-Go Potassium Channels by Cocaine

Molecular Pharmacology, 2001
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Regulation of human ether-a-go-go-related gene potassium channels by EGFR kinase and Src-related tyrosine

2010
Introduction: Protein tyrosine kinases (PTKs) transduce extracellular signals mediate events such as proliferation, cytoskeletal rearrangement, and coordination of physiological responses, and also regulate ion channels. The present study was designed to investigate whether PTKs regulate human ether-a`-go-go-related gene (hERG) channels. Methods: Whole-
Li, GR, Lau, CP, Zhang, D
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Blockade of the Human Ether A-Go-Go-Related Gene (hERG) Potassium Channel by Fentanyl

Fentanyl poses a serious health concern, with abuse and death rates rising over recent years. Despite the high number of overdose deaths attributed to fentanyl, the complete molecular mechanisms of such deaths have not been well-defined. Although activation of opioid receptors in the brainstem causes respiratory depression, in most cases of drug ...
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Discoveries in structure and physiology of mechanically activated ion channels

Nature, 2020
Andrew B Ward, Ardem Patapoutian
exaly  

Piezos thrive under pressure: mechanically activated ion channels in health and disease

Nature Reviews Molecular Cell Biology, 2017
Swetha E Murthy, Adrienne E Dubin, Ardem Patapoutian   +2 more
exaly