Results 41 to 50 of about 298,529 (290)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Are Greeks’ Unconcerned about Ethical Market Choices?"

open access: yesJournal of Economic Development, Environment and People, 2014
An Ethical Unconcern (EthU) scale was constructed and its impact on Positive Ethical Consumption was examined. The procedure of EthU included literature search, brainstorming and discussion groups to generate the preliminary pool of 99 items, refinement ...
Antonia DELISTAVROU, Irene TILIKIDOU
doaj  

Ethical qualities in consumption [PDF]

open access: yesMarketing Theory, 2017
This article seeks to develop an empirically grounded theorization of care. Current care theory tends to be conceived along philosophical, psychological and labour dimensions, with much of the literature focusing on caring labour and, therefore, invoking a productionist orientation.
Shaw, Deirdre   +3 more
openaire   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

The role of guilt and pride in consumers’ self-regulation: an exploration on sustainability and ethical consumption [PDF]

open access: yes, 2012
Researchers are interested in understanding the individual processes that favour consumers’ self-regulation since they can contribute to the achievement of personal and collective long-term goals in many areas.
Antonetti, Paolo
core  

How Do Personal Values Affect Boycott Participation? The Moderating Role of National Culture

open access: yesJournal for Perspectives of Economic Political and Social Integration
The aim of this article is to examine the relationship between personal values and participation in consumer boycotts across countries, taking into account the role of national culture.
Grzegorz Zasuwa, Alicja Węgierak
doaj   +1 more source

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Les gens bien mangent bien : comprendre le répertoire culturel de l’alimentation éthique

open access: yesIdeAs, 2012
Ethical consumption is understood by scholars as a key way that individuals can address social and ecological problems. While a hopeful trend, it raises the question of whether ethical consumption is primarily an elite social practice, especially since ...
Josée JOHNSTON   +2 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

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