Results 111 to 120 of about 1,722,347 (299)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

Molecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska, Stephany Gallardo, Nur S. Zainal, Leena Arora, Matthew Ellis, Maria‐Antoinette Lopez, Judith Austine, Sai Pittla, Serena J Chee, Aiman Alzetani, Emily C Shaw, Christian H Ottensmeier, Gareth J Thomas, Christopher J Hanley   +13 more
wiley   +1 more source

Ethical, Servant, and Agile Leadership in the Healthcare Sector: A Literature Review of Contemporary Leadership Approaches for Modern Healthcare Organizations

مجلة مستقبل العلوم الإجتماعیة
This study investigated three contemporary leadership styles that have become increasingly important in the healthcare sector: ethical leadership, servant leadership, and agile leadership. Healthcare organizations, especially public hospitals, operate in
Ahmed Mohamed Abdel Gaffar El Deeb
doaj   +1 more source

Building a Leader-Follower Culture: The Nexus Between Transformational Leadership and Effective Followership Behaviors

, 2020
Leadership scholars have often used the catchphrase ‘he who must be a good leader must first be a good follower’ to a great extent, and in so doing, have suggested a positive relationship between leadership and followership behaviors.
Alegbeleye, Ibukun Dami, Kaufman, Eric K.   +1 more
core  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

Molecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens, Anouk Mentink, Tom Niessink, Frank Coumans, Leonie Mekenkamp, Ruchi Bansal, Jeroen Hiltermann   +6 more
wiley   +1 more source

The Effect of Ethical Leadership on Organizational Justice, Organızational Citizenship and Job Satisfaction

e-Kafkas Eğitim Araştırmaları Dergisi
The aim of the study is to explain the effect of ethical leadership on organizational justice, organizational citizenship, and job satisfaction. The study group includes 488 teachers and the study was chosen by using a simple random sampling method ...
Muhammet Emin Uzunyaylalı, Muhammet Emre Kılıç, Mehmet Yaşar Kılıç   +2 more
doaj   +1 more source

USP29‐regulated noncanonical stabilization of the hypoxia‐inducible factor‐α in aggressive prostate cancer

Molecular Oncology, EarlyView.
We identify USP29 as the only DUB mirroring CA9 expression, a marker of hypoxia and HIF pathway activation associated with PCA aggressiveness. USP29 stabilizes HIF‐1α and HIF‐2α via a noncanonical mechanism that is independent of PHD/pVHL activity yet relies on proteasomal regulation, establishing USP29 as a previously unrecognized regulator of hypoxic
Amelie S Schober, Leire Moreno‐Cugnon, Laura Martínez‐Pérez, Amaia Ercilla, Amaia Zabala‐Letona, Adrián Vicente‐Barrueco, Maider Fagoaga‐Eugui, Saioa Garcia‐Longarte, Blanca Calle‐Ciborro, Encarnación Pérez‐Andrés, Onintza Carlevaris, Sara Pozo, Isabel Mendizabal, Ugo Mayor, Arkaitz Carracedo, Violaine Sée, Edurne Berra   +16 more
wiley   +1 more source

Why and when does ethical leadership evoke unethical follower behavior?

, 2016
Purpose – In examining whether social exchange or social identity mechanisms drive the relationship between ethical leadership and unethical pro-organizational behavior (UPB), the purpose of this paper is to argue that the mechanism linking ethical ...
van Dijk, H.; id_orcid, van Dijk, H., Kalshoven, K., Boon, C.; id_orcid, Boon, C.   +4 more
core   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

SMEs’ Perspective on How Ethical Leadership Supports Community Engagement in Buyer–Supplier Power Asymmetric Relationships

Administrative Sciences
The increasing moral challenges facing organizations flag the significance of ethical leadership. Despite the significance of promoting moral behavior, the existing literature has scarcely looked at ethical leadership in small and medium enterprises ...
Anastacia Mamabolo, Kerrin Myres, Gideon Pogrund   +2 more
doaj   +1 more source

Designing and Validating the Ethical Leadership Model in Organizations [PDF]

فرایند مدیریت و توسعه, 2019
Today, in analyzing public organizations, it is necessary for leaders to address ethics and ethical values and be unconditionally committed to the accepted ethical principles so that they may convince their staff to achieve any common goals.
Roghaiieh Fathi-Livari, Ali Hamidizadeh, Nasser Sanoubar, Hassan Zareei-Matin   +3 more
doaj