Results 131 to 140 of about 703,286 (353)
FEBS Letters, EarlyView.Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure +3 more
wiley +1 more source
Molecular Oncology, EarlyView.Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee +8 more
wiley +1 more source
A 'novel' approach to leadership development : using women's literary fiction to explore contemporary women's leadership issues : a thesis presented in partial fulfilment of the requirements for the degree of Masters of Business Studies in Management at Massey University, Albany, New Zealand [PDF]
, 2016 The central aim of this thesis is to investigate how women’s literary fiction can be harnessed for the purpose of exploring contemporary women’s leadership issues.
Martin, Lydia Anne
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How Ethical Leadership Shapes Employees’ Readiness to Change: The Mediating Role of an Organizational Culture of Effectiveness [PDF]
, 2019 Dina El‐Metwally +3 more
openalex +1 more source
Molecular Oncology, EarlyView.Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat +8 more
wiley +1 more source
The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity
Molecular Oncology, EarlyView.Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli +7 more
wiley +1 more source
Chasing the honey bee: enhancing leadership for sustainability [PDF]
This paper explores the ways in which different conceptions of leadership can contribute to the sustainability of economic productivity, social equity and, of course, the natural systems and resources upon which all social and economic development depend.
John Fien
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Pengaruh Kepemimpinan Etis Terhadap Prestasi Kerja Pegawai (Studi Kasus Pada Kantor Pajak Pratama Tobelo Kabupaten Halmahera Utara) [PDF]
, 2017 This study aims to determine whether the influence of ethical leadership on the performance of employees at the Tax Office Primary Tobelo Halmahera Utara.
DjelaDjela, K. S. (Kristian) +2 more
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Molecular Oncology, EarlyView.In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge +17 more
wiley +1 more source