Results 171 to 180 of about 12,286,533 (342)

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

An Exploratory Study into the Factors Impeding Ethical Consumerism

open access: yes
Evidence suggests that consumers are increasingly aware of, engaged with, and influenced by ethical factors when forming opinions on products and making purchase decisions.
Bray, Jeffery P.
core  

Credit Markets with Ethical Banks and Motivated Borrowers [PDF]

open access: yes
This paper investigates banks’ corporate social responsibility. Two different competitive credit markets do exist: one for standard projects and one for ethical ones.
Tedeschi, Piero, Barigozzi, Francesca
core   +2 more sources

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Spiritual scriptures impact on six ethical models influencing organizational practices [PDF]

open access: yes, 2006
Moral issues greet the business community constantly, confronting us with problems on handling accounting rules that can determine a company's future.
Gago Rodríguez, Susana   +1 more
core  

Ethical and medico-legal issues of TOETVA procedure and simulation on cadavers: a scoping review

open access: yes, 2022
Conventional open thyroidectomy is still considered the gold standard for thyroid surgery. Transoral endoscopic thyroidectomy vestibular approach (also known as TOETVA) is often considered to be more advantageous than the other approaches, such as ...
Cazzato, F.   +6 more
core  

Longitudinal genome‐wide aneuploidy measurements in circulating cell‐free DNA to predict lack of benefit from pembrolizumab in patients with metastatic urothelial cancer

open access: yesMolecular Oncology, EarlyView.
Many patients with urothelial cancer do not benefit from treatment with pembrolizumab, while at risk of severe side effects. Changes in the levels of circulating tumor DNA early during treatment, measured by a simple and affordable assay that can be easily implemented in the clinic, can be used as a prognostic tool to identify these patients.
Youssra Salhi   +14 more
wiley   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Experience at a Clinical Research Ethical Review Committee

open access: yes, 1981
The membership, functions, and policies of the ethical review committee of University College Hospital, London, are presented. Topics addressed are the committee's stand on mandatory review, the information to be provided with adult and pediatric ...

core  

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