Results 51 to 60 of about 13,577,124 (238)

Safety of Daprodustat for the Treatment of Chronic Kidney Disease Anemia: Final Analysis of a Multicenter Postmarketing Surveillance Study in Japan

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction This final analysis of a multicenter, prospective postmarketing surveillance study evaluated the safety of daprodustat in patients with chronic kidney disease anemia in routine clinical practice in Japan. Methods Patients who initiated daprodustat between September 2020 and July 2022 were registered.
Tadao Akizawa, Kyomi Kanaya, Kiyomi Aizawa, Masanori Onoki, Hirofumi Ozeki, Kazuko Suzuki, Ai Hayashi, Tomohiko Asamura   +7 more
wiley   +1 more source

Ethical Analysis of Protocol Deviations in Clinical Trials: A Retrospective Study in a Hospital (2021—2024)

Yixue yu zhexue
This study, through retrospective analysis, collected protocol deviation events in clinical trials in a tertiary hospital from 2021-2024, grouped and compared them by the scope of implementation, analyzed the categories, impacts, handling methods of the ...
Qian ZHANG, Li HE, Huiting ZHOU, Hongyan ZHOU, Yuqian ZHAO, Min XU   +5 more
doaj   +1 more source

Uncertainties about the need for ethics approval in Switzerland: a mixed-methods study

Swiss Medical Weekly, 2020
BACKGROUND To ensure ethical oversight, researchers wanting to conduct “research” involving human beings are typically required to obtain prior approval from an independent ethics committee.
Viktoria Gloy, Stuart McLennan, Matthias Rinderknecht, Bettina Ley, Brigitte Meier, Susanne Driessen, Pietro Gervasoni, Bernard Hirschel, Pascal Benkert, Ingrid Gilles, Erik von Elm, Matthias Briel   +11 more
doaj   +1 more source

Forecasting the Dialysis Burden in Japan: Validation‐Based Projections of Prevalence and Incidence Through 2050

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Background Japan has one of the highest dialysis prevalence rates worldwide and a shrinking, aging population. Whether dialysis burden has entered a sustained post‐peak phase or whether recent declines partly reflect pandemic‐related disruptions remains uncertain.
Hatice Şahin, Berrak Itır Aylı, Nüket Paksoy   +2 more
wiley   +1 more source

Analysis of Ethical Review Standards and Key Elements for Clinical Trials of Brain-Computer Interface

Yixue yu zhexue
In the ethical review of brain-computer Interface (BCI) technologies and products, it is essential to establish review standards and elements tailored to their unique characteristics, in addition to complying with existing national laws and regulations ...
Qi LU, Ruona AN, Zhonglin CHEN, Jiuhui LI   +3 more
doaj   +1 more source

Association Between Individualized Education for Kidney Replacement Therapy Modality Selection and Peritoneal Dialysis Initiation: A Cross‐Sectional Study

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Peritoneal dialysis (PD) is an established home‐based kidney replacement therapy (KRT), but its uptake remains low in Japan. We evaluated whether individualized education in a dedicated outpatient clinic was associated with the initiation of PD.
Yasuko Ito, Ryuichi Yoshimura, Takaki Yamauchi, Yuta Funakoshi, Hirotaka Sonoda, Seiji Kobayashi, Hiroyuki Terawaki, Takafumi Ito   +7 more
wiley   +1 more source

Analysis of Conflicts of Interest in Clinical Trials and the Pathways for Collaborative Governance

Yixue yu zhexue
Effective management of conflicts of interest is the cornerstone for ensuring the scientific integrity and ethical compliance of clinical trials. Currently, there exists a practical predicament in China where the governance of conflicts of interest in ...
Benze HU, Weihua GUO, Yaqing YANG, Yuhong HUANG   +3 more
doaj   +1 more source

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Analysis of Common Ethical Review Issues in Biomedical Research in Medical Universities

Yixue yu zhexue
This paper conducts an in-depth analysis of the issues existing in the ethical review of biomedical research in medical universities, covering various aspects such as the scientific validity of research design, the standardization of informed consent ...
Hui JIANG, Huixian HUANG, Min CHEN
doaj   +1 more source

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source