Results 61 to 70 of about 16,101,585 (240)

Biphasic Clinical Course of Pediatric Cytomegalovirus‐Associated Immune Thrombocytopenia: Early Poor Treatment Response but Favorable Long‐Term Outcomes

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Cytomegalovirus (CMV) is a recognized trigger of immune thrombocytopenia (ITP); however, its incidence and impact on disease course in children remain controversial. Therefore, we aimed to characterize the clinical course of pediatric patients with CMV‐associated ITP.
Oded Gilad, Ohad Atia, Osama Tanous, Dafna Brik Simon, Michal Dvori, Miriam Cohen, Tracie A. Goldberg, Efraim Bilavsky, Joanne Yacobovich, Orna Steinberg‐Shemer   +9 more
wiley   +1 more source

Current status and factors influencing research ethics knowledge and attitudes among pediatricians: a cross-sectional survey

Frontiers in Medicine
BackgroundPediatricians play a pivotal role in clinical research, and their research competence is essential for advancing hospital-based studies and fostering the development of pediatric disciplines.
Bingya Zheng, Na Zhang, Hongwen Qin, Lihui Zhu   +3 more
doaj   +1 more source

Bone Mineral Density After Contemporary Treatment for Acute Lymphoblastic Leukaemia: A Matched Cross‐Sectional Study

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Reduced bone mineral density (BMD) has been reported in survivors of childhood and young adult acute lymphoblastic leukaemia (ALL); however, data from cohorts treated with contemporary protocols and including matched controls remain limited.
Karen Schow Jensen, Mette Tiedemann Skipper, Niels Holtum Birkebæk, Kjeld Schmiegelow, Thomas Leth Frandsen, Bente Langdahl, Rikke Beck Jensen, Asger Roer Pedersen, Christian Mølgaard, Liv Andrés‐Jensen, Birgitte Klug Albertsen   +10 more
wiley   +1 more source

Ethical Analysis of Protocol Deviations in Clinical Trials: A Retrospective Study in a Hospital (2021—2024)

Yixue yu zhexue
This study, through retrospective analysis, collected protocol deviation events in clinical trials in a tertiary hospital from 2021-2024, grouped and compared them by the scope of implementation, analyzed the categories, impacts, handling methods of the ...
Qian ZHANG, Li HE, Huiting ZHOU, Hongyan ZHOU, Yuqian ZHAO, Min XU   +5 more
doaj   +1 more source

Uncertainties about the need for ethics approval in Switzerland: a mixed-methods study

Swiss Medical Weekly, 2020
BACKGROUND To ensure ethical oversight, researchers wanting to conduct “research” involving human beings are typically required to obtain prior approval from an independent ethics committee.
Viktoria Gloy, Stuart McLennan, Matthias Rinderknecht, Bettina Ley, Brigitte Meier, Susanne Driessen, Pietro Gervasoni, Bernard Hirschel, Pascal Benkert, Ingrid Gilles, Erik von Elm, Matthias Briel   +11 more
doaj   +1 more source

Chemotherapy for Spinal Cord Intramedullary Pediatric Low‐Grade Glioma—A Systematic Literature Review

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric intramedullary low‐grade gliomas (PIMLGGs) are rare neoplasms that present unique clinical and management challenges. Although surgery remains the primary tool for tissue diagnosis and decompression, complete gross‐total resection is frequently unfeasible due to the infiltrative nature of these lesions.
Olga M. Sergeenko, Segev Gabay, Jonathan Roth, Amit Ringel, Rina Dvir, Shlomi Constantini   +5 more
wiley   +1 more source

Analysis of Ethical Review Standards and Key Elements for Clinical Trials of Brain-Computer Interface

Yixue yu zhexue
In the ethical review of brain-computer Interface (BCI) technologies and products, it is essential to establish review standards and elements tailored to their unique characteristics, in addition to complying with existing national laws and regulations ...
Qi LU, Ruona AN, Zhonglin CHEN, Jiuhui LI   +3 more
doaj   +1 more source

Exercise Capacity, Physical Activity, Fatigue, and Neurocognitive Function in Adult Survivors of Childhood Acute Lymphoblastic Leukemia

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Adult survivors of childhood acute lymphoblastic leukemia (ALL) are at risk of reduced exercise capacity, decreased physical activity levels, persistent fatigue, and neurocognitive deficits. The aim was to investigate exercise capacity and physical activity levels of adult survivors of childhood ALL and their associations with ...
Laura Jess, Gustaf Glavå, Simon Skau, Hans‐Georg Kuhn, Maria Bäck, Marianne Jarfelt   +5 more
wiley   +1 more source

Analysis of Conflicts of Interest in Clinical Trials and the Pathways for Collaborative Governance

Yixue yu zhexue
Effective management of conflicts of interest is the cornerstone for ensuring the scientific integrity and ethical compliance of clinical trials. Currently, there exists a practical predicament in China where the governance of conflicts of interest in ...
Benze HU, Weihua GUO, Yaqing YANG, Yuhong HUANG   +3 more
doaj   +1 more source

“We Cannot Talk as a Family”: Complexities of Survivorship Communication Among Hispanic/Latino Young Adult Survivors of Childhood Cancer, Parents, and Clinicians

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Background Young adult childhood cancer survivors (YA‐CCS) have an increased risk of treatment‐related health complications throughout their lives. Lifelong survivorship care is recommended, yet many YA‐CCS experience disruptions in care during pediatric‐to‐adult transitions and do not receive recommended survivorship care.
Kevin Shanchen Pu, Nicole Fernández‐Viña, Briana C. Martin‐Villa, Daniela Ramirez, Rebecca M. Lewinsohn, Mary Smith, Heidi Boynton, Lidia Schapira, Stephanie M. Smith   +8 more
wiley   +1 more source