Results 71 to 80 of about 13,577,124 (238)

Ethical Review of Multi-Centred Trials

, 1990
At present, British researchers conducting multi-center clinical trials must submit their proposals for review to the local ethics committee in each center.
Macara, Alexander W.
core   +1 more source

Applying the institutional review board data repository approach to manage ethical considerations in evaluating and studying medical education

Medical Education Online, 2016
Issue: Medical educators and educational researchers continue to improve their processes for managing medical student and program evaluation data using sound ethical principles. This is becoming even more important as curricular innovations are occurring
Erin K. Thayer, Daniel Rathkey, Marissa Fuqua Miller, Ryan Palmer, George C. Mejicano, Martin Pusic, Adina Kalet, Colleen Gillespie, Patricia A. Carney   +8 more
doaj   +1 more source

The features and qualities of online training modules in research ethics: a case study evaluating their institutional application for the University of Botswana

Global Bioethics, 2020
Research ethics remains a cornerstone of the scientific enterprise as it defines the boundaries of responsible conduct of research. Our aim was to systematically identify, review and test online training courses in research ethics which could be ...
Dolly Mogomotsi Ntseane, Joseph Ali, Kristina Hallez, Boikanyo Mokgweetsi, Mary Kasule, Nancy E. Kass   +5 more
doaj   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Responsibility: a principle to resume in bioethical reflection

Iatreia, 2019
Science and its arm, technology, may focus on an anthropocentric logic if they insist on satisfying only human needs at the expense of the mastery (or destruction) of nature and coexisting species.
Zapata Ospina, Juan Pablo
doaj   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

International Perspectives and Chinese Practice in the Ethical Review of Brain-Computer Interfaces

Yixue yu zhexue
The rapid development of brain-computer interface (BCI) has posed unprecedented challenges to traditional ethical frameworks, raising core issues related to personal autonomy, privacy protection, risk governance, and social equity. This paper reviews the
Xiaoshan LIANG, Caizhen BAI, Yi YANG, Xiaolin YUE   +3 more
doaj   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Ethical Dilemmas of Brain-Computer Interface Technologies and Products from the Perspective of Ethical Review

Yixue yu zhexue
Brain-computer interface (BCI) technologies and products are not only a medical treatment modality, but also involve the information and privacy protection of individual patients and patient groups, while bearing implications for national biosafety.
Jiuhui LI, Jianyu CHEN, Ruona AN, Xiaoyun CHEN   +3 more
doaj   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

Molecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner, Pierre Tennstedt, Randi C. Pose, Christian Müller, Katharina Besler, Svenja Schneegans, Malik Alawi, Marie C. Roesch, Sven Peine, Desiree Bonci, Joanna Budna‐Tukan, Evi Lianidou, Catherine Alix‐Panabières, Derya Tilki, Klaus Pantel   +14 more
wiley   +1 more source