Results 41 to 50 of about 267,661 (261)

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

FEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure, Misaki K. Nishio, Satoru Okuda, Kohji Hotta   +3 more
wiley   +1 more source

The patient suicide attempt – An ethical dilemma case study

International Journal of Nursing Sciences, 2015
Case description: Nurses face more and more ethical dilemmas during their practice nowadays, especially when they are taking care of the patient at end of life stage. The case study demonstrates an ethical dilemma when nursing staff are taking care of an
Lin Jie
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

A Comparison of the Metaphysical Egoism of ʿAllāma Ṭabāṭabāʾī With Egoistic Theories in Ethics [PDF]

آموزه‌‌های فلسفه اسلامي
The discussion of egoism versus altruism, or benevolence, is a significant topic in contemporary ethical philosophy. Egoism is categorized into psychological egoism and ethical egoism. From the perspective of psychological egoism, as a descriptive theory,
Ḥamīd Ḥassanī, Donyā Ḥamīdī
doaj   +1 more source

Biomedical Ethics and Ethical Theories

Korean Journal of Medical Ethics, 1998
By the mid-1960s, there has been a consensus among English-speaking philosophers as to the role of philosophy: Analytic philosophers and logical positivists widely agreed that philosophy has nothing to say about practical moral issues. However, moral philosophers began to recognize their role in diverse fields; in particular, medicine and health-care.
openaire   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

COMP–PMEPA1 axis promotes epithelial‐to‐mesenchymal transition in breast cancer cells

Molecular Oncology, EarlyView.
This study reveals that cartilage oligomeric matrix protein (COMP) promotes epithelial‐to‐mesenchymal transition (EMT) in breast cancer. We identify PMEPA1 (protein TMEPAI) as a novel COMP‐binding partner that mediates EMT via binding to the TSP domains of COMP, establishing the COMP–PMEPA1 axis as a key EMT driver in breast cancer.
Konstantinos S. Papadakos, Gilar Gorji‐bahri, Lejla Gradjan, Julia Zajac, Kacper Gil, Yvonne Thokozile Nduku, Anna M. Blom   +6 more
wiley   +1 more source

Profesionalismo en enfermería, el hábito de la excelencia del cuidado Profissionalismo em enfermagem, o hábito da excelência do cuidado Professionalism in nursing, the habit of excellence in health care

Avances en Enfermería, 2010
Enfermería precisa un cambio cualitativo en la práctica profesional, por ello se sugiere transitar de la profesionalización al profesionalismo en enfermería como camino para alcanzar la excelencia profesional y la calidad en el cuidado.
MITZI LETELIER VALDIVIA, ANA LUISA VELANDIA MORA   +1 more
doaj  

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source

Utopia as the Gift of Ethical Genius: Ernst Cassirer’s Theory of Utopia

Eidos. A Journal for Philosophy of Culture, 2018
In this essay, I explore Cassirer’s brief discussion of utopia in An Essay on Man, as likely built upon Kant’s theory of genius as from the Critique of Judgment.
Eli Kramer
doaj   +1 more source