Results 51 to 60 of about 267,661 (261)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Ayn Rand’s Egoism: Theory and Analysis [PDF]
Religious Inquiries, 2015 Ayn Rand was a Russian-born American philosopher, novelist, and playwright, whose interpretation of ethical egoism is one of the most important interpretations of this theory.
Raham Sharaf +1 more
doaj
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Formulation of “Principle of Compatibility with innate nature” in Imam Khomeini’s Ethical Thought [PDF]
پژوهشنامه متینImam Khomeini’s ethical theory is an innate nature -centered thought based on which ethics, i.e. ethical insights and tendencies become instances of rules and requisites for an innate desire to love good and perfection and to manifest a hatred of evil ...
Hassan Mahdipour
doaj +1 more source
Molecular Oncology, EarlyView.Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova +14 more
wiley +1 more source
Trans/Form/AçãoIn the 1980s, the new humanism ethical criticism gradually returned to the mainstream of Western literary theory and criticism academia, realizing the ethical turn of literary theory criticism. The New Aristotelian camp is represented by Wayne Booth and
Qiaozhu Zhang
doaj +1 more source
The Criterion of Ethical Rules in the Islamic Political System [PDF]
اخلاق وحیانی, 2016 The aim of this paper is to investigate the basis and criterion of ethical values in Islamic political system. The implementation of ethical rules in a political system requires a knowledge of its ethical criterion.
s.fateme faghihi
doaj
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source