Results 101 to 110 of about 3,310,200 (292)

Improving PARP inhibitor efficacy in bladder cancer without genetic BRCAness by combination with PLX51107

Molecular Oncology, EarlyView.
Clinical trials on PARP inhibitors in urothelial carcinoma (UC) showed limited efficacy and a lack of predictive biomarkers. We propose SLFN5, SLFN11, and OAS1 as UC‐specific response predictors. We suggest Talazoparib as the better PARP inhibitor for UC than Olaparib.
Jutta Schmitz, Anna L. Bartkowiak, Michael Rose, Nora Kolks, Patrick Petzsch, Vandana Solanki, Anne Stoffel, Bianca Faßbender, Leandra Lepping, Julka Volkamer, Karl Köhrer, Marc Seifert, Tokameh Mahmoudi, Tahlita C. M. Zuiverloon, Günter Niegisch, Michèle J. Hoffmann   +15 more
wiley   +1 more source

PARTIAL SEIZURES IN PUPPIES DUE TO Otodectus cyanotisINFESTATION- A REPORT OF TWO CASES [PDF]

Journal of Veterinary and Animal Sciences, 2017
A seizure is the clinical manifestation of an excessive discharge of hyperexcitable cerebrocortical neurons. Partial seizures have a focal onset in one of the cerebral hemisphere and limited spreading within the brain (Quesnel, 2010).
Deepa Chirayath, K Syamala, Silpa Sasi, T.R. Rajin   +3 more
doaj  

Ethics in clinical research

Journal of Hepatology, 2009
R&D of new drugs is driven by pharmaceutical companies that invest considerable amounts of money for this purpose. This may introduce bias, to emphasize the clinical value of drugs to be allowed onto the market. Bias is caused by methodological flaws including the population under study, the choice of inadequate comparators or of their dosage, the ...
Garattini, Silvio, Bertele', Vittorio
openaire   +3 more sources

Model consent clauses for rare disease research [PDF]

, 2019
Background: Rare Disease research has seen tremendous advancements over the last decades, with the development of new technologies, various global collaborative efforts and improved data sharing.
Goldblatt, Jack, Isasi, Rosario, Jagut, Marlene, Jonker, Anneliene Hechtelt, Kaufmann, Petra, Kautmann, Petra, Knoppers, Bartha, Knoppers, Bartha Maria, Molnar-Gabor, Fruszina, Nguyen, Minh Thu, Ouillade, Laetitia, Shabani, Mahsa, Sid, Eric, Tasse, Anne Marie, Tasse, Anne-Marie, Wong-Rieger, Durhane   +15 more
core   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

PREPARATION OF EXCRETORY SECRETORY PROTEIN FROM BRUGIAN MICROFILARIAE ISOLATED FROM CANINE BLOOD [PDF]

Journal of Veterinary and Animal Sciences, 2019
The article describes the culture of microfilaria of Brugia spp. for the extraction of excretory-secretory protein. The microfilariae were separated from the various components of canine blood using HiSep™ LSM by gradient centrifugation method.
Poojary Vineeta Sadarama, Deepa Chirayath, Usha Narayana Pillai, Madhavan Unny, Bindu Lakshmanan   +4 more
doaj  

Class IIa HDACs forced degradation allows resensitization of oxaliplatin‐resistant FBXW7‐mutated colorectal cancer

Molecular Oncology, EarlyView.
HDAC4 is degraded by the E3 ligase FBXW7. In colorectal cancer, FBXW7 mutations prevent HDAC4 degradation, leading to oxaliplatin resistance. Forced degradation of HDAC4 using a PROTAC compound restores drug sensitivity by resetting the super‐enhancer landscape, reprogramming the epigenetic state of FBXW7‐mutated cells to resemble oxaliplatin ...
Vanessa Tolotto, Nicolò Gualandi, Ylenia Cortolezzis, Raffaella Picco, Monica Colitti, Francesca D'Este, Mariachiara Gani, Wayne W. Hancock, Giovanni Terrosu, Cristina Degrassi, Francesca Agostini, Claudio Brancolini, Luigi E. Xodo, Eros Di Giorgio   +13 more
wiley   +1 more source

Psychedelic therapy and cultural humility

Translational Psychiatry
Importance As psychedelic-assisted therapies gain clinical legitimacy, their cultural portability remains underexamined. While promising results have emerged from trials on existential distress in life-limiting illness, most protocols reflect Euro ...
Alex Gearin, Jennifer Docherty, Xiaofan Sun, Emmanuel Hei-Lok Cheung, Peter Tanuseputro   +4 more
doaj   +1 more source

Case Report: Atypical neuroleptic malignant syndrome induced by paliperidone palmitate—diagnostic challenges and clinical considerations

Frontiers in Psychiatry
Poor treatment adherence is common in schizophrenia and constitutes a major risk factor for relapse and clinical instability. Long-acting injectable (LAI) antipsychotics are frequently prescribed to mitigate this risk; however, their use can be ...
Omar El Oumary, Omar El Oumary, Hicham Laaraj, Mina Ouhamou, Khalid Mouhadi, Jalal Doufik, Jalal Doufik, Khadija Akebour, Khadija Akebour, Saliha Hamri, Ismail Rammouz, Ismail Rammouz   +11 more
doaj   +1 more source

Reflecting on the Reasons Pros and Cons Coercive Measures for Patients in Psychiatric and Somatic Care: The Role of Clinical Ethics Consultation. A Pilot Study

Frontiers in Psychiatry, 2019
Background and aim: Coercive measures in patient care have come under criticism leading to implement guidelines dedicated to the reduction of coercion. This development of bringing to light clinical ethics support is hoped to serve as a means of building
Elena Montaguti, Jan Schürmann, Charlotte Wetterauer, Mario Picozzi, Stella Reiter-Theil   +4 more
doaj   +1 more source