Results 121 to 130 of about 2,371,082 (294)
Ethics Consultation in the Emergency Department
, 2007 Clinical ethics teams exist in various forms and have assisted care providers for several decades. Our clinical ethics service at an urban, tertiary, teaching hospital provides ethics consultation to care providers, patients, and their family members ...
Anderson-Shaw, Lisa +2 more
core +1 more source
Neuronal cell adhesion molecule regulating neural systems underlying addiction
Neuropsychopharmacology Reports, 2019 Aims The human NRCAM gene is associated with polysubstance use. Nrcam knockout mice do not acquire a preference for addictive substances. We aimed to elucidate the role of Nrcam in specific neural circuits underlying congenital preference for substances ...
Hiroki Ishiguro +5 more
doaj +1 more source
Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer
Molecular Oncology, EarlyView.COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann +61 more
wiley +1 more source
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
Multiprofessional Education in Social Medicine and Clinical Ethics
, 1997 This contribution describes a project of multiprofessional education in social medicine and clinical ethics based on educational experience of 3rd Department of Internal Medicine, First Medical Faculty, Charles University in conjunction with the Centre ...
Hrubantova, L. +2 more
core
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
HAEMATOBIOCHEMICAL CHANGES ASSOCIATED WITH CUTANEOUS VASCULITIS IN DOGS [PDF]
Journal of Veterinary and Animal Sciences, 2019 The present study documents the haematological and serum biochemical parameters in cutaneous vasculitis in dogs. Cutaneous vasculitis is the inflammation of blood vessels of dermis and subcutaneous tissue.
G.R. Chaitra +4 more
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
, 2008 Background: Few comparative studies of clinical ethics consultation practices have been reported. The objective of this study was to explore how American and Japanese experts analyze an Alzheimer's case regarding ethics consultation.
Fujita, Misao +6 more
core +1 more source
A scoping review of ethical decisions and decision tools for experimental animal protocols
BMC Medical EthicsBackground Scientific research projects involving animals are required to undergo ethical evaluation, generally known as harm-benefit analysis (HBA), to ensure that they address important ethical concerns related to animal welfare and the scientific ...
David Mawufemor Azilagbetor +5 more
doaj +1 more source