Results 101 to 110 of about 2,371,082 (294)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

open access: yesFEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi   +5 more
wiley   +1 more source

Case Analysis in Clinical Ethics

open access: yes, 2005
Notes on contributors -- Acknowledgements -- Ch. 1. Philosophical introduction: case analysis in clinical ethics / Richard Ashcroft, Michael Parker, Marian Verkerk, Guy Widdershoven -- Ch. 2. Families and genetic testing: the case of Jane and Phyllis /
Jonsen, Albert R.
core  

Impact of recent legislative bills regarding clinical research on Italian ethics committee activity.

open access: yes, 2008
: Aims and background: The present work assessed the impact of two decrees on ethics committees in Italy, aimed at bringing the national laws on the conduct of clinical trials into line with the rest of the EC, and regulating and facilitating not-for ...
POLI D   +10 more
core   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

Constructing a Systematic Review for Argument-Based Clinical Ethics Literature: The Example of Concealed Medications

open access: yes, 2007
The clinical ethics literature is striking for the absence of an important genre of scholarship that is common to the literature of clinical medicine: systematic reviews.
McCullough, Laurence B.   +2 more
core   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

open access: yesFEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai   +9 more
wiley   +1 more source

Enriching Our Values on Clinical Ethics: Results of a Qualitative Study of the Moral Psychology of Healthcare Ethics Committee Members

open access: yes, 2008
The contribution of healthcare ethics committee (HEC) members to HECs is fundamental. However, little is known about how HEC members view clinical ethics. We report results from a qualitative study of the moral psychology of HEC members.
Racine, Eric
core  

PARTIAL SEIZURES IN PUPPIES DUE TO Otodectus cyanotisINFESTATION- A REPORT OF TWO CASES [PDF]

open access: yesJournal of Veterinary and Animal Sciences, 2017
A seizure is the clinical manifestation of an excessive discharge of hyperexcitable cerebrocortical neurons. Partial seizures have a focal onset in one of the cerebral hemisphere and limited spreading within the brain (Quesnel, 2010).
Deepa Chirayath   +3 more
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

open access: yesFEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa   +2 more
wiley   +1 more source

Issues in Clinical Ethics Consultation: An Introduction

open access: yes, 1992
Any area that surges ahead as rapidly as this one [clinical ethics] has over the last five years is virtually certain to find that there are many problems which will need to be addressed.
Skeel, Joy D.
core   +1 more source

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