Results 111 to 120 of about 2,371,082 (294)

PREPARATION OF EXCRETORY SECRETORY PROTEIN FROM BRUGIAN MICROFILARIAE ISOLATED FROM CANINE BLOOD [PDF]

Journal of Veterinary and Animal Sciences, 2019
The article describes the culture of microfilaria of Brugia spp. for the extraction of excretory-secretory protein. The microfilariae were separated from the various components of canine blood using HiSep™ LSM by gradient centrifugation method.
Poojary Vineeta Sadarama, Deepa Chirayath, Usha Narayana Pillai, Madhavan Unny, Bindu Lakshmanan   +4 more
doaj  

Reflecting on the Reasons Pros and Cons Coercive Measures for Patients in Psychiatric and Somatic Care: The Role of Clinical Ethics Consultation. A Pilot Study

Frontiers in Psychiatry, 2019
Background and aim: Coercive measures in patient care have come under criticism leading to implement guidelines dedicated to the reduction of coercion. This development of bringing to light clinical ethics support is hoped to serve as a means of building
Elena Montaguti, Jan Schürmann, Charlotte Wetterauer, Mario Picozzi, Stella Reiter-Theil   +4 more
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Paediatrics at the Cutting Edge: Do We Need Clinical Ethics Committees?

, 1997
OBJECTIVES: To investigate the need for hospital clinical ethics committees by studying the frequency with which ethical dilemmas arose, the perceived adequacy of the process of their resolution, and the teaching and training of staff in medical ethics ...
McCarthy, Jean M., Lask, Bryan, Larcher, Victor F.   +2 more
core   +1 more source

Psychedelic therapy and cultural humility

Translational Psychiatry
Importance As psychedelic-assisted therapies gain clinical legitimacy, their cultural portability remains underexamined. While promising results have emerged from trials on existential distress in life-limiting illness, most protocols reflect Euro ...
Alex Gearin, Jennifer Docherty, Xiaofan Sun, Emmanuel Hei-Lok Cheung, Peter Tanuseputro   +4 more
doaj   +1 more source

Case Report: Atypical neuroleptic malignant syndrome induced by paliperidone palmitate—diagnostic challenges and clinical considerations

Frontiers in Psychiatry
Poor treatment adherence is common in schizophrenia and constitutes a major risk factor for relapse and clinical instability. Long-acting injectable (LAI) antipsychotics are frequently prescribed to mitigate this risk; however, their use can be ...
Omar El Oumary, Omar El Oumary, Hicham Laaraj, Mina Ouhamou, Khalid Mouhadi, Jalal Doufik, Jalal Doufik, Khadija Akebour, Khadija Akebour, Saliha Hamri, Ismail Rammouz, Ismail Rammouz   +11 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

Ethical issues in the use of in-depth interviews: literature review and discussion [PDF]

, 2009
This paper reports a literature review on the topic of ethical issues in in-depth interviews. The review returned three types of article: general discussion, issues in particular studies, and studies of interview-based research ethics.
Tod, A., Clarke, Amanda, McDonnell, A., McDonnell, Ann, Allmark, P., Chambers, E., Allmark, Peter, Chambers, Eleni, Tod, Angela Mary, Allmark, P. J., Boote, J., Thompson, A.R., Thompson, Andrew, Clarke, A., Thompson, A., Boote, Jonathan, Tod, Angela   +16 more
core   +1 more source

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

Molecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge, Morten Tulstrup, Gabriele Todisco, Pedro Moura, Christophe Côme, Jakob Werner Hansen, Jakob Schmidt Jespersen, Balthasar Schlotmann, Maria Creignou, Mette Dahl, Claudia Schöllkopf, Klas Raaschou‐Jensen, Krister Wennerberg, Bo Porse, Joachim Weischenfeldt, Eva Hellström‐Lindberg, Lasse Sommer Kristensen, Kirsten Grønbæk   +17 more
wiley   +1 more source

Pre‐analytical optimization of cell‐free DNA and extracellular vesicle‐derived DNA for mutation detection in liquid biopsies

Molecular Oncology, EarlyView.
Pre‐analytical handling critically determines liquid biopsy performance. This study defines practical best‐practice conditions for cell‐free DNA (cfDNA) and extracellular vesicle–derived DNA (evDNA), showing how processing time, storage conditions, tube type, and plasma input volume affect DNA integrity and mutation detection.
Jonas Dohmen, Lucrezia De Santis, Bret M. Stephens, Vincent Bernard, Jörg C. Kalff, Lara Braun, Phillipp Leyendecker, Johannes Röttgen, Daniel Weissinger, Anirban Maitra, Paola A. Guerrero, Alexander Semaan   +11 more
wiley   +1 more source