Results 81 to 90 of about 7,899,887 (331)
Plasmodium falciparum gametogenesis essential protein 1 (GEP1) is a transmission‐blocking target
FEBS Letters, EarlyView.This study shows Plasmodium falciparum GEP1 is vital for activating sexual stages of malarial parasites even independently of a mosquito factor. Knockout parasites completely fail gamete formation even when a phosphodiesterase inhibitor is added. Two single‐nucleotide polymorphisms (V241L and S263P) are found in 12%–20% of field samples.
Frederik Huppertz +5 more
wiley +1 more source
Curricular priorities for business ethics in medical practice and research: Recommendations from Delphi consensus panels [PDF]
, 2014 BACKGROUND: No published curricula in the area of medical business ethics exist. This is surprising given that physicians wrestle daily with business decisions and that professional associations, the Institute of Medicine, Health and Human Services ...
Bakanas, Erin +4 more
core +2 more sources
The concept of vulnerability in medical ethics and philosophy
Philosophy, Ethics, and Humanities in Medicine, 2019 Healthcare is permeated by phenomena of vulnerability and their ethical significance. Nonetheless, application of this concept in healthcare ethics today is largely confined to clinical research.
J. Boldt
semanticscholar +1 more source
FEBS Letters, EarlyView.Atovaquone is an antimalarial requiring potentiation for sufficient efficacy. We pursued strategies to enhance its activity, showing that 4‐nitrobenzoate inhibits 4‐hydroxybenzoate polyprenyltransferase, decreasing ubiquinone biosynthesis. Since atovaquone competes with ubiquinol in mitochondria, 4‐nitrobenzoate facilitates its action, potentiating ...
Ignasi Bofill Verdaguer +7 more
wiley +1 more source
Testimony Before the Subcommittee of the Senate Judiciary Committee [PDF]
, 1974 This testimony was originally published in the May 81, 1974 issue of Commonweal under the title Protecting the Unborn. Reprinted with permission from Commonweal, 232 Madison Avenue, New York , N. Y. 10016. Dr.
Ramsey, Paul
core +1 more source
MyAirCoach: The use of home-monitoring and mHealth systems to predict deterioration in asthma control and the occurrence of asthma exacerbations; Study protocol of an observational study [PDF]
, 2016 © Published by the BMJ Publishing Group Limited. Introduction Asthma is a variable lung condition whereby patients experience periods of controlled and uncontrolled asthma symptoms.
Bonini, Matteo +8 more
core +4 more sources
FEBS Letters, EarlyView.Anaplastic thyroid cancer (ATC) lacks iodide uptake ability due to MAPK activation increasing the expression of the histone methyltransferase EZH2, which represses thyroid differentiation genes (TDGs) such as the sodium iodide symporter (NIS). Dual inhibition of MAPK (U0126) and EZH2 (EPZ6438/Tazemetostat) reverses this mechanism, thus restoring TDG ...
Diego Claro de Mello +6 more
wiley +1 more source
Demographics, Ethics, Awareness [PDF]
, 2010 Ethics in medicine is not a new concern. But it has become much more pronounced in modern times. The issues involved may range from right diagnosis and right treatment to the fees charged to patients, and the administration of insurance and medical bills.
Joshi, Himanshu +3 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Disclosure of Medical Errors in Oman : Public preferences and perceptions of current practice
Sultan Qaboos University Medical Journal, 2015 Objectives: This study aimed to provide insight into the preferences for and perceptions of medical error disclosure (MED) by members of the public in Oman.
Mark I. K. Norrish
doaj