Results 171 to 180 of about 23,286,365 (332)

Research ethics: ethical review and beyond

Science is a collective endeavor highly dependent on public acceptance and trust. Research findings must be reliable to serve the surrounding society as well as the research community itself. Evidence-based practice and policy recommendations may become ineffective or even dangerous if based on fraudulent research findings.
Elin Palm, Lars Lindblom
openaire   +2 more sources

Research ethics committees in Africa: Authors' reply [PDF]

, 2007
Ajuwon, A, Appiah-Poku, J, Barsdorf, N, Elsayed, DE, Hyder, AA, Kass, NE, Mokhachane, M, Mupenda, B, Ndebele, P, Ndossi, G, Sikateyo, B, Tangwa, G, Tindana, P   +12 more
core   +3 more sources

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source

DISCUSSION: AGRO-ETHICS -- EXTENSION, RESEARCH, AND TEACHING [PDF]

Teaching/Communication/Extension/Profession,
Coutu, Arthur J.
core   +1 more source

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

Establishing a peer advisory board in a mental health ethics research group - challenges, benefits, facilitators and lessons learned. [PDF]

Front Psychiatry
Faissner M, Braun E, Efkemann SA, Gaillard AS, Haferkemper I, Hempeler C, Heuer I, Lux U, Potthoff S, Scholten M, Spiegel S, Stefaniak C, Thesing M, Werning A, Gather J.   +14 more
europepmc   +1 more source

Genetic attenuation of ALDH1A1 increases metastatic potential and aggressiveness in colorectal cancer

Molecular Oncology, EarlyView.
Aldehyde dehydrogenase 1A1 (ALDH1A1) is a cancer stem cell marker in several malignancies. We established a novel epithelial cell line from rectal adenocarcinoma with unique overexpression of this enzyme. Genetic attenuation of ALDH1A1 led to increased invasive capacity and metastatic potential, the inhibition of proliferation activity, and ultimately ...
Martina Poturnajova, Zuzana Kozovska, Ondrej Pos, Kristina Pavlov, Sachin Gulati, Peter Makovicky, Kristina Jakic, Monika Burikova, Eva Sedlackova, Barbora Svitkova, Silvia Tyciakova, Vojtech Bystry, Nicolas Blavet, Boris Tichy, Matej Hrnciar, Jaroslav Budis, Miroslav Tomas, Peter Dubovan, Georgina Kolnikova, Veronika Repaska, Nikoleta Mojzesova, Eva Zomborska, Daniel Pindak, Michal Mego, Tomas Szemes, Miroslava Matuskova   +25 more
wiley   +1 more source

Non-empirical methods for ethics research on digital technologies in medicine, health care and public health: a systematic journal review. [PDF]

Med Health Care Philos
Ursin F, Müller R, Funer F, Liedtke W, Renz D, Wiertz S, Ranisch R.   +6 more
europepmc   +1 more source

Ethics of conducting qualitative social science research in the emerging field of nanotechnology [PDF]

In educational research, qualitative studies have varied meanings. This short paper reviews the conceptual underpinnings of ethics in qualitative social science research and its importance to the emerging field of nanotechnology.
Yawson, Robert M.
core   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source