Results 171 to 180 of about 4,465,471 (397)

Basroparib inhibits YAP‐driven cancers by stabilizing angiomotin

Molecular Oncology, EarlyView.
Basroparib, a selective tankyrase inhibitor, suppresses Wnt signaling and attenuates YAP‐driven oncogenic programs by stabilizing angiomotin. It promotes AMOT–YAP complex formation, enforces cytoplasmic YAP sequestration, inhibits YAP/TEAD transcription, and sensitizes YAP‐active cancers, including KRAS‐mutant colorectal cancer, to MEK inhibition.
Young‐Ju Kwon, Dong Young Kim, Yuna Kim, Uk‐Il Kim, Jae‐Sung Kim   +4 more
wiley   +1 more source

A Survey Study on Knowledge and Attitude Toward the Ethics Committee and Research Ethical Practices Among Researchers From Kuwait. [PDF]

Sci Eng Ethics, 2023
Shiju R, Thankachan S, Akhil A, Sharma P, Bennakhi A.   +4 more
europepmc   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Meeting of the Eastern Mediterranean Research Ethics Review Committee

, 2018
WHO Regional Office for the Eastern Mediterranean
openalex   +1 more source

Diabetes‐induced vascular calcification is associated with low pyrophosphate and its oral supplementation prevents calcification in diabetic mice

FEBS Open Bio, EarlyView.
Induction of diabetes in three different mouse strains uniformly resulted in an increase in TNAP activity and a reduction in pyrophosphate (PPi) in the circulation. Inhibition of TNAP restored plasma PPi. Diabetes‐induced calcification in the media layer of the aorta was detected only in the Abcc6−/− strain, which is predisposed to ectopic ...
Krisztina Fülöp, Eszter Kozák, Natália Tőkési, Lilian Kocsis, Anikó Kelemen, Zsuzsanna Geszti, Adriána Kutás, Mariann Harangi, Ágnes Diószegi, Zsolt Rapi, József Balla, Olivier Le Saux, András Váradi, Viola Pomozi   +13 more
wiley   +1 more source

Exploring perspectives of research ethics committee members on the governance of big data in sub-Saharan Africa. [PDF]

S Afr J Sci, 2023
Cengiz N, Kabanda SM, Esterhuizen TM, Moodley K.   +3 more
europepmc   +1 more source

Planned oocyte cryopreservation for women seeking to preserve future reproductive potential: an Ethics Committee opinion.

Fertility and Sterility, 2018
J. Daar, J. Benward, L. Collins, Joseph B. Davis, O. Davis, Leslie Francis, E. Gates, E. Ginsburg, S. Gitlin, S. Klipstein, L. Mccullough, R. Paulson, R. Reindollar, G. Ryan, M. Sauer, Sean Tipton, L. Westphal, J. Zweifel   +17 more
semanticscholar   +1 more source

Pathogenic Neurofibromatosis type 1 gene variants in tumors of non‐NF1 patients and role of R1276

FEBS Open Bio, EarlyView.
Somatic variants of the neurofibromatosis type 1 (NF1) gene occur across neoplasms without clinical manifestation of the disease NF1. We identified emerging somatic pathogenic NF1 variants and hotspots, for example, at the arginine finger 1276. Those missense variants provide fundamental information about neurofibromin's role in cancer.
Mareike Selig, Swanhild Lohse, Sara Elahi, Nils Hartmann, Stefanie Deckert, Shutian Si, Alexander Desuki, Anja Harder   +7 more
wiley   +1 more source

Ethical issues in clinical research

Indian Journal of Plastic Surgery, 2007
Thatte Urmila
doaj   +1 more source

A Retrospective Study of Ethics Committee Monitoring Checklists of the Audiovisual Consent Process: An Ethical Perspective. [PDF]

Cureus, 2023
Shetty YC, Tripathi R, Marathe PA, Jalgaonkar S, Gajbhiye S, Katkar J.   +5 more
europepmc   +1 more source