Results 51 to 60 of about 2,103,507 (310)

Enteropathogenic E. coli shows delayed attachment and host response in human jejunum organoid‐derived monolayers compared to HeLa cells

FEBS Letters, EarlyView.
Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi, Pilar Samperio Ventayol, Natalie Burkard, Nicolas Schlegel, Carmen Aguilar, Sina Bartfeld   +5 more
wiley   +1 more source

Perceptions of neuromuscular electrostimulation of patients with Parkinson’s disease and their caregivers: the impact on swallowing and speech from a qualitative perspective

Journal of Patient-Reported Outcomes
Purpose Parkinson’s disease (PD) is a progressive neurodegenerative disorder that manifests itself through motor and non-motor symptoms, which significantly influence quality of life.
Mariana de Almeida Simão, Silvia Poveda-Moral, Elizabeth Ramírez Daniel, Aracely Domínguez Ganora, Militza Vergara Vargas, Jaime Kulisevsky   +5 more
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Health and the Environment: The Vulnerability of Female Populations

, 2020
Memo by the Inserm Ethics Committee. Gender and Health Research group.
Vidal, Catherine, Ethics Committee Members, -   +1 more
core  

Ethics review or compliance check? an empirical analysis of 6740 requests for information in Belgian clinical trial evaluations (2017–2024)

BMC Medical Ethics
The EU Clinical Trials Regulation (CTR) was introduced to harmonize clinical trial evaluations across Member States while upholding participant protection and ethical integrity.
Audrey Van Scharen, Michel Deneyer, Pieter Cornu   +2 more
doaj   +1 more source

A survey in Mexico about ethics dumping in clinical research

BMC Medical Ethics, 2019
Background The exportation of unethical practices to low- and middle-income countries (“Ethics Dumping”) has been conceived as a prevalent practice which needs to be examined more closely.
Novoa-Heckel Germán, Bernabe Rosemarie
doaj   +1 more source

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Ethical review key considerations for organoid applications in biomedical research—a systematic review

Frontiers in Cell and Developmental Biology
The organoid co-culture model, a novel tool for reconstructing three-dimensional microenvironments to study cell-cell interactions, has demonstrated significant potential in biomedical research in recent years. It holds considerable value for elucidating
Guo Zhili, Zhang Nenghua
doaj   +1 more source

Nominalism in Medicine: the case of personalized medicine or precision medicine

Italian Journal of Medicine, 2017
Not ...
Italo Portioli
doaj   +1 more source