Results 71 to 80 of about 2,103,507 (310)

Ethical issues in access to and delivery of emergency department care in an era of changing reimbursement and novel payment models

open access: yesJournal of the American College of Emergency Physicians Open, 2020
Hospital emergency departments (EDs) and the emergency physicians, nurses, and other health professionals who provide emergency care in them, are a critical component of the United States (US) health care system in the 21st century.
Chadd K. Kraus   +4 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Advisory board : engineering ethics case study project

open access: yes, 2010
This is an Engineering Ethics case study from the IDEA CETL. It examines how membership of an advisory committee might lead to a conflict of interest. It considers integrity and public duty.
Inter-Disciplinary Ethics Applied Cetl, University of Leeds
core  

Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma

open access: yesMolecular Oncology, EarlyView.
The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic   +5 more
wiley   +1 more source

Gender and Health: beware of clichés

open access: yes, 2017
Videos presented at the health training seminar proposed at the initiative of the "Gender and Health Research" working group of the Inserm Ethics ...
Ethics Committee Members, -
core  

Challenges associated with ethics review of educational research at a South African university

open access: yesActa Academica, 2011
This article analyses the decisions and feedback from reviewers of a decentralised ethics committee to applicants in a two-year period. Results indicate that the review of research protocols by an ethics committee are complicated by challenges related ...
Salome Human-Vogel, Sonja Coetzee
doaj   +3 more sources

Research Ethics Committees [PDF]

open access: yesBritish Journal of General Practice, 2008
Trials and Tribulations by Saul Miller1 takes the National Research Ethics Service to task for the closure of the Northumberland Research Ethics Committee (REC), but there are compelling reasons behind this decision. The Northumberland closure is part …
openaire   +2 more sources

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

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