Results 91 to 100 of about 47,967 (295)

The ethics of war-time data in paediatric trauma: attitudes, angles and impacts. [PDF]

open access: yesBMJ Glob Health, 2023
Taghavi K   +4 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

open access: yesMolecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain   +10 more
wiley   +1 more source

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Wars of the Middle Ages

open access: yesУправленческое консультирование, 2018
The article discusses the role of war in the life of medieval society. Particular attention is paid to the human dimension of war. The author notes the characteristics of war in the Middle Ages. The article highlighted the distinctive features of the war
Vladimir Kuzmich Karnaukh
doaj  

Christian Ethics and Ecologies of Violence

open access: yesReligions, 2019
This essay introduces “ecologies of violence” as a problem for Christian ethics. Understanding the links between violence and the natural environment will be critical to the pursuit of justice, peace, and sustainability in the twenty-first ...
Luke Beck Kreider
doaj   +1 more source

Adaptor protein CIN85 potentiates the motility of osteosarcoma cells via the Akt/mTOR and MMP2‐COL3A1 axis

open access: yesMolecular Oncology, EarlyView.
CIN85 is highly expressed in osteosarcoma, particularly in metastatic lesions. Its overexpression increases cell migration and Matrigel invasion, while silencing CIN85 suppresses these behaviors. Transcriptome analysis shows that CIN85 regulates MMP2, COL3A1, and Akt/mTOR signaling. Targeting these pathways reverses CIN85‐induced motility, highlighting
Iryna Horak   +10 more
wiley   +1 more source

The ethics of war: critical alternatives

open access: yes, 2010
The 'just war' is not the only tradition that has thought deeply about the moral and ethical context of the use of organised violence. This chapter offers an account of some of the critical alternative approaches to the ethics of war.
Patricia Owens (4462981)
core   +1 more source

What Is A Just War? A Reading Of Michael Walzer's Thought [PDF]

open access: yesZiglôbitha
: War embodies numerous negative values, such as violence, conflict, hostility, and hatred. These elements prompt us to reflect on moral considerations and, at times, to seek different reasons to justify the existence of war.
Abdellah MOUSSA & Noura ABED
doaj   +1 more source

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

open access: yesMolecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena   +15 more
wiley   +1 more source

The Ethics of War and Peace : An Introduction

open access: yes, 2023
 The Ethics of War and Peace is a lively introduction to one of the oldest but still most relevant ethical debates. Focusing on the philosophical questions surrounding the ethics of modern war, Helen Frowe presents contemporary just war theory in a ...
Frowe, Helen,
core  

Home - About - Disclaimer - Privacy