Results 101 to 110 of about 47,967 (295)

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

open access: yesMolecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen   +9 more
wiley   +1 more source

ESR1 methylation and ESR1 mutations in circulating tumor cells (CTCs) and paired plasma‐cfDNA of advanced breast cancer patients: A feasibility proof‐of‐concept study

open access: yesMolecular Oncology, EarlyView.
Circulating tumor cells (CTCs) and plasma cell‐free DNA (cfDNA) were analyzed to detect ESR1 mutations and methylation in patients with advanced breast cancer. CTC‐derived DNA showed higher sensitivity for mutation detection and revealed complementary genetic and epigenetic alterations, highlighting the added value of CTC analysis for understanding ...
Dimitra Stergiopoulou   +12 more
wiley   +1 more source

The ethics of war and the force of law ::a modern just war theory /

open access: yes, 2020
This book provides a thorough critical overview of the current debate on the ethics of war, as well as a modern just war theory that can give practical action-guidance by recognizing and explaining the moral force of widely accepted law.
Steinhoff, Uwe,
core  

Reimagining Violence in Contemporary Africa: Catholic Martyrdom and the Ethics of Sacrificial Solidarity in Burundi

open access: yesReligions
This article discusses the enculturated Catholic ethics of martyrdom embodied by the Martyrs of Fraternity of Burundi, a group of students whose cause is now before the Vatican’s Congregation for the Causes of Saints for refusing to separate into Hutus ...
Jodi Mikalachki
doaj   +1 more source

Islam and the Provisions of War

open access: yesAl 'Adalah: Jurnal Hukum Islam, 2019
This article compares the provisions of war in Islam with the provisions contained in International Humanitarian Law (The four Geneva Conventions of 1949 and their Additional Protocols).
Henry Iwansyah
doaj   +1 more source

DNA methylation and expression of MAPRE3 affect overall survival of early‐stage non‐small cell lung cancer patients

open access: yesMolecular Oncology, EarlyView.
Both cg12821679MAPRE3 methylation and MAPRE3 expression are significantly associated with overall survival (OS) of non‐small cell lung cancer. Meanwhile, MAPRE3 expression significantly modified the effect of smoking cessation on OS. Smoking cessation benefits OS merely for patients with high MAPRE3 expression.
Chao Chen   +14 more
wiley   +1 more source

Circulating tumor cell viability during and after radiotherapy mirrors treatment response in cancer patients

open access: yesMolecular Oncology, EarlyView.
Radiotherapy (RT) response depends on the DNA repair capacity of tumor and host cells. We show that circulating tumor cell (CTC) counts and apoptosis rates before and after RT predict treatment response and outcome, which can be accessed via easily accessible liquid biopsy approaches. Created in BioRender. Wikman, H.
Yvonne Goy   +10 more
wiley   +1 more source

War by Algorithm: Giambattista Vico and Ethics of War in the Techno-Logical Era [PDF]

open access: yes, 2019
In an era where humans are increasingly being replaced or augmented by technological innovation, how might the humanist tradition offer us guiding questions for ethics of war today? My talk will explore the U.S.
Emery, John Robert
core  

Efectividad del daño y desdibujamiento del sujeto: aproximaciones a las narrativas sobre el sufrimiento en el conflicto armado colombiano

open access: yesRevista de Estudios Sociales, 2017
In this article I discuss some ways of relating to human suffering that have characterized research undertakings and the practice of defending human rights in Colombia that have constituted certain types of narratives about war and political violence in ...
Juan Pablo Aranguren Romero
doaj   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

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