Results 81 to 90 of about 47,967 (295)
Molecular Oncology, EarlyView.Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch +13 more
wiley +1 more source
HUMAN VALUES IN THE SHADOW OF MACHINE WAR: ETHICAL AND EXISTENTIAL CHALLENGES
Освітній дискурсRelevance of the research. In the current context of rapid innovation development, warfare is increasingly referred to as a “technological war” or a “confrontation of machines”.
Ruslan Filonenko
doaj +1 more source
Somatic mutational landscape in von Hippel–Lindau familial hemangioblastoma
Molecular Oncology, EarlyView.The causes of central nervous system (CNS) hemangioblastoma in Von Hippel–Lindau (vHL) disease are unclear. We used Whole Exome Sequencing (WES) on familial hemangioblastoma to investigate events that underlie tumor development. Our findings suggest that VHL loss creates a permissive environment for tumor formation, while additional alterations ...
Maja Dembic +5 more
wiley +1 more source
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Levinas and the Ethics of War and Peace
, 2018 This essay considers the role of war in Levinas’s philosophy and his philosophy’s place in the secondary literature on the ethics of war. It is argued that his understanding of war most closely matches just war theory, although it bears similarities as ...
Joshua Shaw
core +1 more source
Artificial Intelligence in the Military Domain and Military Ethics: Key Challenges and Implications
Obrana a StrategieThis article explores the current and emerging applications of artificial intelligence (AI) across military domains and examines the critical ethical challenges these developments present.
Dragan Stanar
doaj +1 more source
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
The Ethics of War and Peace. An Introduction
, 2012 Item does not contain fulltextH. Frowe The Ethics of War and Peace. An Introduction London:Routledge ,2011 9780415492393 S.
Peperkamp, L.
core
The Tianxia System and the Search for a Common Ground in the Comparative Ethics of War
, 2018 This paper explores the conclusions of recent research on the ethics of war in Chinese traditional political thought, asking how they have been shaped by understandings of the nature, meaning and significance of global ethical diversity.
Hwang, Y.J., Frettingham, E.
core +2 more sources