Results 71 to 80 of about 14,007,730 (234)

Transcriptional profiling of circulating extracellular vesicles from prebiopsy prostate cancer patients

open access: yesMolecular Oncology, EarlyView.
RNA profiling of circulating extracellular vesicles (EVs) from blood samples of men undergoing prostate biopsy identifies transcripts associated with clinically significant prostate cancer. Integrative analysis with public tumor datasets links EV‐derived gene signatures to tumor stage and progression‐free survival, highlighting CASP3, XRCC2, and RIT1 ...
Stefan Werner   +14 more
wiley   +1 more source

Review: Will van den Hoonaard (Ed.) (2002). Walking the Tightrope: Ethical Issues for Qualitative Researchers

open access: yesForum: Qualitative Social Research, 2004
This publication basically represents a collection of former conference papers and some other contributions mainly by North American social scientists on the dilemmas that qualitative researchers encounter when they submit research applications to ...
Rod Gerber
doaj  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Un projet de recherche exempté d’évaluation éthique : une suggestion de clarification sur le processus d’évaluation éthique

open access: yesBioéthiqueOnline, 2013
This letter proposes a clarification regarding the use of the TCPS2 for ethics review in response to the exemption from review of a specific research proposal by the research ethics board of the organisation.
Caillé, Jean, Beauregard, Guy
doaj  

Flow Enabled Target Capture Halbach‐based magnetic enrichment increases circulating tumor cell capture from blood in metastatic cancer patients

open access: yesMolecular Oncology, EarlyView.
Pair‐wise comparison of the CellSearch and FETCH enrichment technologies for circulating tumor cells (CTCs) from metastatic breast, prostate, and small cell lung cancer patients shows an increased capture of CTCs using FETCH enrichment. The clinical implementation of circulating tumor cells (CTCs) as a predictive tool for therapy efficacy in the ...
Michiel Stevens   +6 more
wiley   +1 more source

Un projet de recherche exempté d’évaluation éthique : quelques précisions

open access: yesBioéthiqueOnline, 2013
This piece responds to the comments made by Caillé and Beauregard by offering clarifications regarding the exemption from ethics review of a research project.
Durand, Céline, Fortin, Marie-Chantal
doaj  

Governing the Game-Changer: Reimagining Peer Review in the Age of AI

open access: yesTrends in Scholarly Publishing
The peer review system, long regarded as the cornerstone of scholarly publishing, is facing unprecedented strain. Rising submission volumes, reviewer fatigue, and increasing instances of research misconduct have revealed deep structural vulnerabilities ...
Lucy Threadgold   +4 more
doaj   +1 more source

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

open access: yesMolecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka   +9 more
wiley   +1 more source

Challenges and Countermeasures for Investigator-Initiated Trial Using Unlisted Medical Devices by Chinese Researchers

open access: yesZhongguo yiliao qixie zazhi
As an important part of clinical diagnosis and treatment, the safety and effectiveness of medical devices are directly related to patients' lives and health.
Shuo LIU, Jiyin ZHOU
doaj   +1 more source

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