Results 81 to 90 of about 1,148 (171)

Mitochondria‐Damaging Self‐Reporting Probe for Cancer Therapy

Angewandte Chemie, Volume 138, Issue 32, 3 August 2026.
We developed a class of self‐reporting cationic chemotherapeutic probes that selectively induce mitochondrial damage and apoptosis in cancer cells. Their unique mitochondria‐to‐nucleus fluorescence migration enables real‐time visualization of the therapeutic process. ABSTRACT Mitochondrial damage induced by chemotherapeutic agents through disruption of
Hai Xu, Yura Lee, Sanghee Yoon, Yun Wang, Yejin Cho, Seongyu Choi, Lu Lu, Hua Zhang, Sun Choi, Ki Taek Nam, Juyoung Yoon   +10 more
wiley   +2 more sources

Molecular phylogenetic analysis sheds light on the diversity and evolutionary history of the Neotropical and African Triplophyllum (Tectariaceae)

Journal of Systematics and Evolution, EarlyView.
We used a molecular approach to resolve the evolutionary lineages of Neotropical Triplophyllum, uncovering that current species circumscriptions are hindered by high morphological homoplasy in indument characters. Our results support the recognition of three new species and provide a necessary neotypification for T.
Mauricio Gonçalves Nunes, Amabily Bohn, Jefferson Prado, Regina Y. Hirai, Hanna Tuomisto, Germinal Rouhan, Paulo H. Labiak   +6 more
wiley   +1 more source

High prevalence of a host‐associated Anaplasma lineage in wild coatis (Nasua nasua) from the Brazilian Atlantic Forest

Medical and Veterinary Entomology, EarlyView.
Anaplasma sp. DNA was detected in 47.9% of free‐ranging coatis (Nasua nasua) sampled in Iguaçu National Park, southern Brazil. Molecular analyses revealed a genetically distinct Anaplasma lineage infecting coatis, differing from Anaplasma strains detected in associated tick populations.
Matheus Dias Cordeiro, Paulo César Magalhães‐Matos, Isadora dos Santos Dias, Jônathan David Ribas Chagas, Olívia Zen Gianfrancisco, Ellen Meireles Brandão, Claudia Bezerra da Silva, Bruna de Azevedo Baêta   +7 more
wiley   +1 more source

Evaluation of the Activity of Amino Chalcone Against Staphylococcus Strains Harboring Efflux Pumps

Pharmaceuticals
Background/Objectives: The increasing prevalence of multidrug-resistant Staphylococcus aureus represents a major clinical challenge, primarily driven by the acquisition of multiple resistance mechanisms.
Isydório Alves Donato, Cristina Rodrigues dos Santos Barbosa, Antonio Henrique Bezerra, Suieny Rodrigues Bezerra, Ray Silva Almeida, Cícera Datiane de Morais Oliveira-Tintino, Isaac Moura Araújo, Ewerton Yago de Sousa Rodrigues, Maria Yasmin Cândido de Oliveira, Francisco Ferdinando Cajazeiras, Jayza Maria Lima Dias, Jesyka Macedo Guedes, Jéssica Híade Silva Cristino, Emmanuel Silva Marinho, Márcia Machado Marinho, Hélcio Silva dos Santos, Henrique Douglas Melo Coutinho, Saulo Relison Tintino, Irwin Rose Alencar de Menezes, Francisco Assis Bezerra da Cunha   +19 more
doaj   +1 more source

Photoprotective potential of gadusol against ultraviolet B radiation in melanocytes

Photochemistry and Photobiology, EarlyView.
Gadusol protects melanocytes from ultraviolet B (UVB)‐induced damage without cytotoxicity. Abstract The increasing incidence of skin cancer, including melanoma, combined with the need for ultraviolet (UV) filters that are safe for human health and marine ecosystems, is driving the search for new photoprotective agents.
Andressa Mai Matsumoto, Rocío Isla Naveira, Andy Joel Taipe Huisa, Marcelo Augusto Germani Marinho, Lais Zortéa, José María Monserrat, Agueda Elena Massa, María Sandra Churio, Ana Paula de Souza Votto   +8 more
wiley   +1 more source

On-site rapid detection of ethidium bromide using gold ultramicroelectrode sensors

Measurement: Sensors
Ethidium bromide (EtBr) is one of the most used non-protein molecules in molecular biology, specifically for fluorescence-based detection of nucleic acids during gel electrophoresis.
Marcello Valente, Ian Seymour, Md Ridwan Adib, Javier Higes-Marquez, Tarun Narayan, Valentina Alessandria, Luca Cocolin, Kieran G. Meade, Alan O'Riordan   +8 more
doaj   +1 more source

Development of chalcones structure‐related to avobenzone: Photoprotection, photostability, and safety evaluation

Photochemistry and Photobiology, EarlyView.
Scaffold hopping strategy used to develop chalcones structure‐related to the avobenzone tautomer. Positive aspects of 2‐hydroxychalcones are highlighted. Abstract Chalcones are α,β‐unsaturated ketones with extended π‐conjugation, making them promising scaffolds for the development of organic UV filters.
Gabriela Zanella Marcon, Taíne de Bastos Brum, Nayara Fernanda Tokashike de Araujo, Gabriela Lascala Ramos, Bruna Cogo Borin, Ruth Barin, Aline Ferreira Ourique, André Passaglia Schuch, Andréa Inês Horn Adams, Lorena Rigo Gaspar Cordeiro, Letícia Cruz, Fernando Fumagalli   +11 more
wiley   +1 more source

Response of Melissa officinalis subsp. officinalis seedlings to Fe3O4‐NPs under in vitro conditions: physiological, biochemical and molecular analyses

Plant Biology, EarlyView.
Iron oxide nanoparticles influence the growth, antioxidant capacity, and gene activity of Melissa officinalis subsp. officinalis plants in vitro, revealing their potential as modulators of secondary metabolism. Abstract Application of iron oxide nanoparticles (NP) (Fe3O4‐NPs) in plant biotechnology presents new opportunities for enhancing metabolic ...
E. Bektaş, H. Şahin, H. İ. Güler, K. İ. Bektaş, K. Kaltalioğlu, N. E. Uzun   +5 more
wiley   +1 more source

Ethidium bromide-induced demyelination of the sciatic nerve of adult Wistar rats

Brazilian Journal of Medical and Biological Research, 2002
Peripheral nerve ultrastructure was assessed after single or multiple local injections of the intercalating dye ethidium bromide. Thirty-four adult Wistar rats of both sexes were divided into five groups and maintained in a controlled environment with ...
Riet-Correa G., Fernandes C.G., Pereira L.A.V., Graça D.L.   +3 more
doaj  

Satellite Glial Cells Synthesize and Release GABA to Activate Extrasynaptic GABAA Receptors That Modulate Dorsal Root Ganglia Neuron Excitability

Glia, Volume 74, Issue 9, September 2026.
Mechanism of synthesis, release, receptor activation, uptake, and degradation of GABA in dorsal root ganglia (DRG). Left: GABA is synthesized from putrescine in satellite glial cells (SGCs). After being released by Best1 channel, it activates GABAA receptors in sensory neurons, producing a chloride current.
Natalie Jiménez‐Barrios, Ricardo González‐Ramírez, Francisco Javier Paz‐Bermúdez, Guadalupe Raya‐Tafolla, José Segovia Vila, Ricardo Felix, Rodolfo Delgado‐Lezama, Benjamín Florán Garduño   +7 more
wiley   +1 more source