Results 131 to 140 of about 241,979 (317)

Raman flow cytometry based single‐cell species classification, viable‐cell counting and vitality test for probiotic products

open access: yesiMetaOmics, EarlyView.
Raman flow cytometry (RFC) enables rapid, high‐throughput quality assessment of probiotic products by classifying species/strains, counting viable cells, and quantifying vitality at single‐cell resolution. With 10‐fold higher throughput and excellent accuracy, RFC outperforms traditional methods and offers a label‐free, automated platform for probiotic
Jia Zhang   +17 more
wiley   +1 more source

Biosafety Evaluation of 6,7‐Dihydroxy‐3‐(2‐Nitrophenyl)Coumarin in Human Cells

open access: yesJournal of Applied Toxicology, EarlyView.
ABSTRACT Coumarins are considered a privileged scaffold in medicinal chemistry, as they may interact with biological macromolecules, presenting several pharmacological properties. Their potential makes them an object of study for the evaluation of their safety for humans, which is essential in the design of a potential drug.
Júlia Zocca Nunes de Barros   +3 more
wiley   +1 more source

Extracting physical chemistry from mechanics: a new approach to investigate DNA interactions with drugs and proteins in single molecule experiments

open access: yes, 2015
In this review we focus on the idea of establishing connections between the mechanical properties of DNAligand complexes and the physical chemistry of DNA-ligand interactions.
Rocha, M. S.
core   +1 more source

Curcumin Internalization in Streptococcus mutans Biofilms: A Confocal Microscopy Analysis

open access: yesJournal of Biophotonics, EarlyView.
Streptococcus mutans are harmful bacteria to oral health, exhibiting high resistance in their biofilm form. This study evaluated, through Confocal Microscopy, curcumin extracted from Curcuma longa as a photosensitizer in photodynamic inactivation (PDI), monitoring its internalization time and activity.
Rebeca Vieira de Lima   +4 more
wiley   +1 more source

Histidine Decapeptide‐Incorporating Lipid Nanoparticles with Low Ionizable Lipids Proportion for Efficient Small Interfering RNA Delivery

open access: yesMacromolecular Bioscience, EarlyView.
Following optimization of ionizable lipid proportion via cost‐efficient vortex‐mixing method, lipid nanoparticles (LNPs) with a lower ionizable lipid proportion (27.72%), termed LNP5, are fabricated with histidine decapeptide (His10) during formulation via microfluidic mixing method. His10‐incorporated LNP5 (LNP5H) exhibited a 1.6‐fold increase in gene
Yeonho Bae   +4 more
wiley   +1 more source

Voltammmetric Assessment and Examination of the Interactions between Levetiracetam and DNA: Experimental Research, Molecular Docking, and Modeling Studies

open access: yesChemistryOpen, EarlyView.
This research introduces, for the first time, a novel, efficient, cost‐effective, and highly sensitive approach for the quantification of levetiracetam (LEV) through a differential pulse voltammetry technique based on its interaction with DNA. The method capitalizes on the changes observed in the oxidation current peak of the deoxyguanosine base, which
Abdullah Al Faysal   +3 more
wiley   +1 more source

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