Results 161 to 170 of about 241,979 (317)

USP44, ZNF454, and GPRC5B ctDNA Methylation Markers in Breast Cancer: Limited Clinical Relevance for Disease Monitoring and Tumor Characteristics

open access: yesAsia-Pacific Journal of Clinical Oncology, EarlyView.
We selected breast cancer‐specific DNA methylation markers using The Cancer Genome Atlas (TCGA). We analyzed the methylation and expression patterns of candidate genes in breast cancer cell lines, ctDNA, and tissue samples. The relationship between ctDNA methylation markers and the clinicopathological features of breast cancer patients was investigated.
Young Ju Jeong   +6 more
wiley   +1 more source

Invasive insect genetics: Start codon targeted (SCoT) markers provide superior data to describe genetic diversity of brown marmorated stink bug, Halyomorpha halys, in a newly colonized region

open access: yesEntomologia Experimentalis et Applicata, EarlyView.
In this study, we assessed the genetic diversity of Halyomorpha halys, an invasive agricultural pest, in Türkiye using start codon targeted (SCoT) markers and mitochondrial cytochrome c oxidase subunit I (COI) sequences. SCoT markers revealed high polymorphism (91.4%) and six genetic clusters among 71 specimens from 12 provinces, with Trabzon showing ...
Ismail Oguz Ozdemir   +5 more
wiley   +1 more source

A CRISPR‐Cas9‐based system for the dose‐dependent study of DNA double‐strand break sensing and repair

open access: yesThe FEBS Journal, EarlyView.
Using CRISPR‐Cas9, we engineered a genetic system allowing the dose‐dependent induction of a controllable number of DNA double‐strand breaks in Saccharomyces cerevisiae. The tool was used to study the kinetics of DNA break sensing and repair, including the spatial distribution of Tel1ATM kinase, which initiates the DNA damage response.
Morgane Auboiron   +5 more
wiley   +1 more source

Human tissue kallikrein 14 induces the expression of IL‐6, IL‐8, and CXCL1 in skin fibroblasts through protease‐activated receptor 1 signaling

open access: yesThe FEBS Journal, EarlyView.
Human tissue kallikrein 14 (KLK14), a skin protease, may mediate paracrine signaling in wound healing. KLK14 released by epithelial cells activates fibroblasts via PAR‐1 activation, inducing IL‐6, IL‐8, and CXCL1 expression. These cytokines in turn promote keratinocyte proliferation and migration, resulting in wound closure.
Laura Sasiadek   +16 more
wiley   +1 more source

Mycobacterium avium Subsp. paratuberculosis and Human Endogenous Retrovirus in Italian Patients With Inflammatory Bowel Disease (IBD) and Irritable Bowel Syndrome (IBS)

open access: yesImmunology, EarlyView.
Inflammatory bowel disease (IBD), comprising ulcerative colitis (UC) and Crohn's disease (CD), is a recognised gastrointestinal disorder. Mycobacterium avium subspecies paratuberculosis (MAP) is implicated in IBD pathogenesis. Persistent exposure and active infections by MAP may contribute to the unsilencing of human endogenous retroviruses (HERV ...
Stefano Ruberto   +14 more
wiley   +1 more source

Transmission electron microscopy and scanning force microscopy of poly r(A‐U) and poly r(A‐U)‐ethidium bromide [PDF]

open access: bronze, 1997
Jacques Gilloteaux   +4 more
openalex   +1 more source

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