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Binding of ethidium bromide to fractionated chromatin
Experimental Cell Research, 1976Abstract The binding of ethidium bromide (EB) to different chromatin preparations was tested. Scatchard plots showed that the slowly sedimenting fraction of sheared chromatin is enriched in dye-binding sites. Limited nuclease digestion of rat liver nuclei, which has been shown to preserve the subunit structure of chromatin, reduces the number of ...
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Binding of ethidium bromide to avian erythrocyte chromatin
Biochemical and Biophysical Research Communications, 1972Summary Ethidium bromide intercalation studies indicate that mature avian erythrocyte chromatin has 5.6 times fewer primary binding sites than deproteinized DNA. The number of both primary and secondary binding sites was increased upon removal of chromosomal proteins; among those, removal of avian erythrocyte specific histone V shows the highest ...
P F, Lurquin, V L, Seligy
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Neurotoxic Effects of Ethidium Bromide, Rat
1988Pathologic lesions are produced by a direct exposure of the central and peripheral nervous tissues to ethidium bromide which is a red dye. Therefore the lesion appears red or reddish-orange and softer than the surrounding tissue.
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Complex formation between ethidium bromide and nucleic acids
Journal of Molecular Biology, 1965The interaction between ethidium bromide and nucleic acids shows a pronounced metachromatic effect which has been used to obtain quantitative data on the process of complex formation. Ethidium binds strongly to both DNA and RNA at sites which appear to be saturated when one drug molecule is bound for every 4 or 5 nucleotides.
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Ethidium bromide resistance and enhancement of mitochondrial recombination
Molecular and General Genetics MGG, 1974In some yeast cytoplasmic mutants, ethidium bromide resistance is expressed at the mitochondrial level. In homosexual crosses it leads to an enhanced recombination between two linked mitochondrial genes controlling chloramphenicol and erythromycin resistance or sensitivity, but recombination is still reciprocal.
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