Results 141 to 150 of about 416,755 (262)

E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer

Molecular Oncology, EarlyView.
Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov, Shiva Krishna Katkam, Zhefan Wang, Venkateshwar G. Keshamouni   +3 more
wiley   +1 more source

Reference intervals of hematological parameters in the Chilean adult population and the Mapuche ethnic group. [PDF]

Adv Lab Med
Letelier PJ, Chicahual CA, Arroyo NF, Monsalves DP, Boguen RE, Guzmán NH.   +5 more
europepmc   +1 more source

Drug Resistance of Mycobacterium tuberculosis Based on Whole-Genome Sequencing in the Yi Ethnic Group, Sichuan Province, China. [PDF]

J Immunol Res, 2023
Gao W, Chen X, Yao L, Li J, Gao Y, Li T, Li Y, Wang W, Zhang S, He J.   +9 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Restorativeness mediates the effect of a brief virtual reality mindfulness exposure with a multi-ethnic group in a natural environment on global identity salience: a pilot study with adolescents. [PDF]

Front Psychol
Russo C, Romano L, Clemente D, Congiu A, Rodelli R, Navarini C, Panno A.   +6 more
europepmc   +1 more source

Group Dynamics and Allocation of Advanced Heart Failure Therapies-Heart Transplants and Ventricular Assist Devices-By Gender, Racial, and Ethnic Group. [PDF]

J Am Heart Assoc, 2023
Breathett K, Yee R, Pool N, Thomas Hebdon MC, Knapp SM, Herrera-Theut K, de Groot E, Yee E, Allen LA, Hasan A, Lindenfeld J, Calhoun E, Carnes M, Sweitzer NK.   +13 more
europepmc   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Inequalities in colorectal cancer diagnosis by ethnic group: a population-level study in the English National Health Service. [PDF]

BMJ Open Gastroenterol
Birch RJ, Burr NE, Taylor JC, Downing A, Quirke P, Morris EJA, Turvill J, Thoufeeq M.   +7 more
europepmc   +1 more source

Rate of Nutrition-Related Chronic Diseases Among a Multi-Ethnic Group of Uninsured Adults. [PDF]

Cureus, 2022
Ajabshir S, Stumbar S, Lachica I, Gates K, Qureshi Z, Huffman F.   +5 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source