Results 161 to 170 of about 6,446,544 (290)

Influence of Pre-treatment CA 125 Levels on Survival Outcomes Across Ethnic Groups in Ovarian Cancer Patients. [PDF]

J Community Hosp Intern Med Perspect
Bangolo A, Amoozgar B, Zhang L, Alqinai B, Hodzic L, Nadella P, Patel M, Roy K, Lakshmana V, Sharma N, Sultana S, Yohannes B, Tran HH, Ingersoll G, Thet PM, Senevirathne RW, Chandak P, Maharaj N, Aloimonos C, Safdar M, Priyabhashinie C, Samuel B, Bommepalli M, Tun Y, Swarath S, Kumar N, Goyal R, Salih SA, Wiredu IO, Umanets E, Kiadidi LL, Dhakal P, Kaur T, Du D, Gill K, Khan MAR, Arteaga C, Barbosa H, Weissman S.   +38 more
europepmc   +1 more source

APOBEC3 activity and DNA polymerase‐ε deficiency are associated with distinct IDH1 R132 hotspot mutations

Molecular Oncology, EarlyView.
Isocitrate dehydrogenase 1 (IDH1) mutations are highly recurrent in multiple human cancer types, including cholangiocarcinoma and glioma. IDH1 R132C is the most common IDH1 mutation in cholangiocarcinoma and likely arises from APOBEC3A‐ or APOBEC3B‐mediated deamination.
Kelly E. Butler, Bilal A. Lone, Ecem Unal, A. Rouf Banday   +3 more
wiley   +1 more source

Carotid Atherosclerosis and Metabolic Characteristics Among High-Risk Cardiovascular Populations of Four Ethnic Groups - Yunnan Province, China, 2024. [PDF]

China CDC Wkly
Yan W, Wen H, Fu H, Chen B, Song A, Wen W, Chen Y.   +6 more
europepmc   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

Molecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault, Capucine Heraud, Mélissa Correia de Oliveira, Véronique Neaud, Valérie Valesco, Valérie Prouzet‐Mauleon, Béatrice Turcq, Jean‐William Dupuy, Anne‐Aurélie Raymond, Sabrina Croce, Frédéric Saltel, Valérie Lagrée, Violaine Moreau   +12 more
wiley   +1 more source

Health literacy and vaccination attitudes among parents from different ethnic groups: a health belief model approach. [PDF]

BMC Public Health
Deger VB, Butun A.
europepmc   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

Mutant p53R273H disrupts PDPK1 homodimerization and contributes to PDPK1 activation

Molecular Oncology, EarlyView.
How mutant p53R273H drives AKT signaling is unclear. We show that p53R273H, but not wild‐type, directly binds PDPK1 via a mutation‐dependent conformational change. This interaction disrupts inhibitory PDPK1 homodimerization and enhances AKT phosphorylation.
Mei Chee Lim, Alvin Kunyao Guo, Yoko Itahana, Srinivasaraghavan Kannan, Valerie Goh, Mingmin Ong, Terina Yan Wen Tay, Weiying Ye, Sabhashina Radha Krishnan, Jun Nishiyama, Chandra S Verma, Koji Itahana   +11 more
wiley   +1 more source

Genetic polymorphisms in cardiovascular disease susceptibility among different ethnic groups. [PDF]

Bioinformation
Chauhan P, Jha H, Podder A.
europepmc   +1 more source

Targeting the EpCAM‐AXL axis to overcome drug resistance in lung cancer

Molecular Oncology, EarlyView.
Lung cancer cells often evade therapy by hijacking signaling pathways. We reveal that cleaved EpCAM (sEpCAM) stabilizes the oncogenic protein AXL, driving NF‐κB and STAT3‐mediated chemoresistance. This EpCAM‐AXL axis identifies a high‐risk patient subset with poor prognosis.
Alexa Guerrero‐Alba, Mark Shacker, Timothy P. Fleming, Michael A. Smith, Ross M. Bremner, Narendra V. Sankpal   +5 more
wiley   +1 more source

The Variation in IRT in Different Ethnic Groups in England-Implications for a Newborn Screening Programme for CF in Diverse Multiethnic Populations. [PDF]

Int J Neonatal Screen
Greenfield T, Tetlow L, Bonham JR, Collingwood C, Wainwright L, Robinson L, Wright D, Hird B, Ramgoolam T, Griffith C, Shakespeare L, Mirzazadeh M, Garstone R, Finnerty D, Flynn N, Taj N, Desai M.   +16 more
europepmc   +1 more source