Results 71 to 80 of about 1,636,579 (314)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

open access: yesFEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe   +3 more
wiley   +1 more source

Racism psychosis and common mental disorder among ethnic minority groups in England [PDF]

open access: yes
Background. The aim of this study was to explore the relationship between risk of psychosis, common mental disorder (CMD) and indicators of racism among ethnic minority groups in England and how this relationship may vary by particular ethnic groups ...
Bhui, Kamaldeep   +4 more
core   +1 more source

Substrate specificity of Burkholderia pseudomallei multidrug transporters is influenced by the hydrophilic patch in the substrate‐binding pocket

open access: yesFEBS Letters, EarlyView.
Multidrug transporters BpeB and BpeF from the Gram‐negative pathogen Burkholderia pseudomallei have a hydrophilic patch in their substrate‐binding pocket. Drug susceptibility tests and growth curve analyses using an Escherichia coli recombinant expression system revealed that the hydrophilic patches of BpeB and BpeF are involved in the substrate ...
Ui Okada, Satoshi Murakami
wiley   +1 more source

Function‐driven design of a surrogate interleukin‐2 receptor ligand

open access: yesFEBS Letters, EarlyView.
Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang   +9 more
wiley   +1 more source

Mechanisms of parasite‐mediated disruption of brain vessels

open access: yesFEBS Letters, EarlyView.
Parasites can affect the blood vessels of the brain, often causing serious neurological problems. This review explains how different parasites interact with and disrupt these vessels, what this means for brain health, and why these processes matter. Understanding these mechanisms may help us develop better ways to prevent or treat brain infections in ...
Leonor Loira   +3 more
wiley   +1 more source

COMPARISON OF DIAGNOSTIC ACCURACY OF GLYCATED HEMOGLOBIN (HBA1C) AND 2-HOUR POST GLUCOSE FOR DIABETES USING AMERICAN DIABETIC ASSOCIATION (ADA) CUT OFFS IN PAKISTANI POPULATION

open access: yesPakistan Armed Forces Medical Journal, 2018
Objective: To determine median HbA1c level in patients screened for DM and compare the diagnostic accuracy of HbA1c with the currently recommended ADA cut off, using 2 hours (h) plasma glucose (2-h PG) post 75 grams oral glucose tolerance test (OGTT ...
Aysha Habib Khan   +5 more
doaj  

O Blood Group among Medical Students in a Medical College of Nepal: A Descriptive Cross-sectional Study

open access: yesJournal of Nepal Medical Association, 2019
Introduction: In ABO system, O blood group is universal blood donor group. Knowing one's blood type is important for prevention of transfusion mis-match between recipients and donors.
Barun Mahat   +8 more
doaj   +1 more source

Dynamics and Diversity: Ethnic Employment Differences in England and Wales, 1991 - 2001 [PDF]

open access: yes
This paper focuses on two main issues, firstly the extent to which the employment position of the main ethnic minority groups in England and Wales changed between 1991 and 2001 and secondly, a detailed examination of employment amongst ethnic groups in ...
Kenneth Clark, Stephen Drinkwater
core  

Conjectures to the Memes of Indonesian Songs [PDF]

open access: yes, 2008
From the works of mathematical properties of songs, we construct the phylomemetic trees of Indonesian ethnic and traditional songs. The memeplexes are then reflected by the used notes and respective durations as they exhibit the Zipf-Mandelbrot law, the ...
Hokky, Situngkir
core   +1 more source

Time after time – circadian clocks through the lens of oscillator theory

open access: yesFEBS Letters, EarlyView.
Oscillator theory bridges physics and circadian biology. Damped oscillators require external drivers, while limit cycles emerge from delayed feedback and nonlinearities. Coupling enables tissue‐level coherence, and entrainment aligns internal clocks with environmental cues.
Marta del Olmo   +2 more
wiley   +1 more source

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