Results 141 to 150 of about 282,497 (309)
, 2010 This paper explores the issues that secondary history teachers on an Initial Teacher Education (ITE) programme in England encounter in attempting to incorporate more cultural and ethnic diversity into the history curriculum.
Harris, Richard
core
Oriental Studies, 2018 The author of this article gives the review of ethnic history of Oyrats of the western Mongolia and northwest China in second half of the XVIII century.
Utash Borisovich Ochirov
doaj
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
Demographic Outcomes of Ethnic Intermarriage in American History: Italian-Americans through Four Generations [PDF]
This paper presents a new approach to measuring the extent of intermarriage among Americans of different ethnic origins. Using U.S. Census microdata and CPS data, measurements of the rates of Italian- American intermarriages across four generations are ...
Joel Perlmann
core +2 more sources
On the methodology of palaeohistorical reconstructions
Поволжская археология, 2015 Investigations into the pre-written history embracing more than 95% of the history of mankind (prehistory / palaeohistory) differs in terms of its sources and methods from the history taken in its narrow meaning, relying principally on the written ...
Vladimir V. Napolskikh
doaj
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Finding novel vulnerabilities of hypomorphic BRCA1 alleles
Molecular Oncology, EarlyView.Synthetic lethality screens performed to identify novel vulnerabilities often model complete gene loss, thereby overlooking patient‐derived hypomorphic mutations. In this study, we have performed genome‐wide CRISPR screens on BRCA1 hypomorphic mutations, showing BRCA1I26A behaves like wild‐type, while BRCA1R1699Q mimics deficiency. Furthermore, we have
Anne Schreuder +10 more
wiley +1 more source
MITF maintains genome stability in nonmelanocyte lineages
Molecular Oncology, EarlyView.MITF is essential for melanocyte survival and acts as an oncogene in 10%–20% of melanomas. We show that MITF depletion causes genome instability in nonmelanocytic cells, leading to LATS2‐mediated P53 activation, cell cycle arrest, and apoptosis. This study highlights the role of MITF as a genome maintenance factor beyond the melanocyte lineage. Created
Drifa H. Gudmundsdottir +13 more
wiley +1 more source
Geoadria, 2015 U radu su analizirane karte i tekstualni geografski opisi (peljar) zadarskog akvatorija iz djela Kitâb-ı Bahriye (Knjiga pomorstva) osmanskog moreplovca, pirata i kasnije admirala Pîrî Reisa.
Mithad Kozličić +2 more
doaj
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source