Results 121 to 130 of about 6,375,128 (341)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang   +12 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

To the Issue of Studying Ethnic Markers of Kalmyks: Clan Tamghas

open access: yesOriental Studies, 2018
The article considers Kalmyk tamghas in terms of studying ethnic markers and clan structure of Kalmyks as well as transformation processes in management forms.
T. Sharaeva
doaj  

Post-1500 Population Flows and the Long Run Determinants of Economic Growth and Inequity [PDF]

open access: yes
We construct a matrix showing the share of the year 2000 population in every country that is descended from people in different source countries in the year 1500.
David Weil, Louis Putterman
core  

From the Ground Up: Multiethnic Literature in the Humanities Curriculum [PDF]

open access: yes, 1987
Spiritual dismemberment, which many associate with the plight of disinherited Native Americans, has dislocated millions of others in this country as well. Teaching multi-ethnic literature, I note in particular streams of students who like the narrator of
Bedrosian, Margaret
core   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

[Review of] Milton J. Esman (Ed.), Ethnic Conflict in the Western World [PDF]

open access: yes, 1978
Ethnic conflict has reemerged in the economic and political arenas of the western world, less between nation states, more within the boundaries of particular nations.
Frye, Hardy T.
core   +1 more source

Dual PI3K/AKT and CDK4/6 inhibition reveals selective sensitivity in an SHH medulloblastoma stem cell model

open access: yesMolecular Oncology, EarlyView.
Targeted therapy was evaluated in SHH medulloblastoma using neuroepithelial stem cell (NES) and tumor‐derived NES‐like (tNES) models in 2D monolayers and 3D spheroids. PI3K, AKT, and CDK4/6 inhibitors had minimal effects in NES but markedly reduced viability and growth and induced apoptosis in tNES cells, revealing distinct therapeutic vulnerabilities.
Monika Lukoseviciute   +4 more
wiley   +1 more source

Ph. D. of History, Head of Ethnology sector of the Kalmyk Institute for Humanities Studies of the Russian Academy of Sciences

open access: yesOriental Studies, 2018
This article deals with the problems of the origin of Tsokhurovski ulus of the Kalmyk khanate, its history in the 18th century, as well as the problems of the formation of ethnic groups in a nomadic state.
Valery Batyrov
doaj  

Immigrants Assimilate as Communities, not just as Individuals [PDF]

open access: yes
There is a large econometric literature that examines the economic assimilation of immigrants in the United States and elsewhere. On the whole immigrants are seen as atomistic individuals assimilating in a largely anonymous labour market, a view that ...
Andrew Leigh, Timothy J. Hatton
core  

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